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CXCL5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2MGS
Identifikatori
Aliasi	CXCL5
Vanjski ID-jevi	OMIM: 600324 MGI: 1096868 HomoloGene: 88672 GeneCards: CXCL5
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	73,998,677 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	90,909,483 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• CXCR chemokine receptor binding; • cytokine activity; • chemokine activity; • vezivanje identičnih proteina;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• positive regulation of cell population proliferation; • inflammatory response; • response to lipopolysaccharide; • GO:0072468 Transdukcija signala; • cell-cell signaling; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • chemokine-mediated signaling pathway; • cell chemotaxis; • neutrophil mediated immunity; • Hemotaksija; • defense response; • positive regulation of neutrophil chemotaxis; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • neutrophil chemotaxis; • leukocyte chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • cellular response to lipopolysaccharide;
	Izvori:Amigo / QuickGO
Ortolozi
	6374
	20311
	ENSG00000163735
	ENSMUSG00000029371
	P42830
	P50228
	NM_002994
	NM_009141
	NP_002985
	NP_033167
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Citokinski ligand 5 (C-X-C motiv) jest protein koji je kod ljudi kodiran genom CXCL5 ili ENA78 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 114 aminokiselina, а molekulska težina 11.972 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSLLSSRAAR	VPGPSSSLCA	LLVLLLLLTQ	PGPIASAGPA	AAVLRELRCV
CLQTTQGVHP	KMISNLQVFA	IGPQCSKVEV	VASLKNGKEI	CLDPEAPFLK
KVIQKILDGG	NKEN

Funkcija

Protein kodiran ovim genom, CXCL5 je mali citokin u porodici CXC hemokina koji je također poznat kao peptid 78 (ENA-78) za aktiviranje neutrofila izvedenih iz epitela. Proizvodi se nakon stimulacije ćelija upalnim citokinima interleukinom-1 ili faktorom nekroze tumora-alfa.^[8] Ekspresija CXCL5 je također uočena kod eozinofila i može se inhibirati interferonskim tipom II IFN-γ.^[9] Ovaj hemokin stimulira hemotaksiju neutrofila koji imaju angiogena svojstva. Izaziva ove efekte interakcijom sa ćelijskom površinom hemokinskih receptora CXCR1 i CXCR2.^[9] Gen za CXCL5 kodira četiri egzona, a na hromosomu 4 nalazi se sa neloliko drugih hemokinskih gena.^[8]^[10] CXCL5 je uključen u remodeliranje vezivnog tkiva.^[9] Također je opisan kao regulator homeostaze neutrofila.^[11]

Klinički značaj

CXCL5 igra ulogu u smanjenju osjetljivosti na bol od opekotina kod nekih osoba i predstavlja "potencijalni cilj koji se može koristiti za razumijevanje više o boli kod drugih upalnih stanja kao što su artritis i cistitis.^[12] Poznato je da CXCL5 ima hemotaksijske i aktivirajuće funkcije na neutrofile, uglavnom tokom akutnih upalnih odgovora. Međutim, ekspresija CXCL5 je također veća u aterosklerozi (hronično upalno stanje), ali nije povezana s infiltracijom neutrofila. Umjesto toga, CXCL5 ima zaštitnu ulogu u aterosklerozi ,direktno kontrolirajući stvaranje makrofaga pjenaste ćelije.^[13]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163735 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J Biol Chem. 269 (41): 25277–82. doi:10.1016/S0021-9258(18)47243-2. PMID 7929219.
^ "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5".
^ "UniProt, P42830" (jezik: engleski). Pristupljeno 23. 10. 2021.
^ ^a ^b Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J. Biol. Chem. 269 (41): 25277–82. doi:10.1016/S0021-9258(18)47243-2. PMID 7929219.
^ ^a ^b ^c Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). "Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils". Clin. Exp. Allergy. 33 (4): 531–7. doi:10.1046/j.1365-2222.2003.01609.x. PMID 12680872. S2CID 2449190.
^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.
^ Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Bushman FD, Worthen GS (2012). "Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice". Journal of Clinical Investigation. 122 (3): 974–986. doi:10.1172/JCI60588. PMC 3287232. PMID 22326959.
^ Dawes JM, Calvo M, Perkins JR, Paterson KJ, Kiesewetter H, Hobbs C, Kaan TK, Orengo C, Bennett DL, McMahon SB (juli 2011). "CXCL5 Mediates UVB Irradiation-Induced Pain". Sci Transl Med. 3 (90): 90ra60. doi:10.1126/scitranslmed.3002193. PMC 3232447. PMID 21734176. Sažetak – FierceBiotech.
^ Rousselle A, Qadri F, Leukel L, Yilmaz R, Fontaine JF, Sihn G, Bader M, Ahluwalia A, Duchene J (2013). "CXCL5 limits macrophage foam cell formation in atherosclerosis". Journal of Clinical Investigation. 123 (3): 1343–7. doi:10.1172/JCI66580. PMC 3582141. PMID 23376791.

Dopunska literatura

Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). "A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5". J. Immunol. 179 (7): 4849–56. doi:10.4049/jimmunol.179.7.4849. PMC 3696729. PMID 17878384.
Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). "Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease". J. Leukoc. Biol. 62 (5): 604–11. doi:10.1002/jlb.62.5.604. PMID 9365115. S2CID 20141618.
Struyf S, Proost P, Van Damme J (2004). "Regulation of the immune response by the interaction of chemokines and proteases". Adv. Immunol. Advances in Immunology. 81: 1–44. doi:10.1016/S0065-2776(03)81001-5. ISBN 978-0-12-022481-4. PMID 14711052.
Walz A, Burgener R, Car B, et al. (1992). "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8". J. Exp. Med. 174 (6): 1355–62. doi:10.1084/jem.174.6.1355. PMC 2119025. PMID 1744577.
Power CA, Furness RB, Brawand C, Wells TN (1995). "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets". Gene. 151 (1–2): 333–4. doi:10.1016/0378-1119(94)90682-3. PMID 7828901.
Corbett MS, Schmitt I, Riess O, Walz A (1995). "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)". Biochem. Biophys. Res. Commun. 205 (1): 612–7. doi:10.1006/bbrc.1994.2709. PMID 7999089.
Koch AE, Kunkel SL, Harlow LA, et al. (1994). "Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis". J. Clin. Invest. 94 (3): 1012–8. doi:10.1172/JCI117414. PMC 295150. PMID 8083342.
Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets". Cytokine. 7 (6): 479–82. doi:10.1006/cyto.1995.0065. PMID 8580362.
Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.
Keates S, Keates AC, Mizoguchi E, et al. (1997). "Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis". Am. J. Physiol. 273 (1 Pt 1): G75–82. doi:10.1152/ajpgi.1997.273.1.G75. PMID 9252512.
Wuyts A, Proost P, Lenaerts JP, et al. (1998). "Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78". Eur. J. Biochem. 255 (1): 67–73. doi:10.1046/j.1432-1327.1998.2550067.x. PMID 9692902.
Wyrick PB, Knight ST, Paul TR, et al. (1999). "Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis". J. Infect. Dis. 179 (4): 954–66. doi:10.1086/314676. PMID 10068592.
Wuyts A, Govaerts C, Struyf S, et al. (1999). "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms". Eur. J. Biochem. 260 (2): 421–9. doi:10.1046/j.1432-1327.1999.00166.x. PMID 10095777.
Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. (1999). "Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines". FASEB J. 13 (12): 1565–74. doi:10.1096/fasebj.13.12.1565. hdl:2027.42/154508. PMID 10463948. S2CID 7043800.
Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils". J. Immunol. 164 (11): 5961–9. doi:10.4049/jimmunol.164.11.5961. PMID 10820279.
Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). "Control of chemokine production at the blood–retina barrier". Immunology. 101 (3): 426–33. doi:10.1046/j.0019-2805.2000.01105.x. PMC 2327097. PMID 11106948.
Zhang C, Thornton MA, Kowalska MA, et al. (2001). "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus". Blood. 98 (3): 610–7. doi:10.1182/blood.V98.3.610. PMID 11468158.
Chandrasekar B, Melby PC, Sarau HM, et al. (2003). "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway". J. Biol. Chem. 278 (7): 4675–86. doi:10.1074/jbc.M207006200. PMID 12468547.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Vanjski linkovi

Lokacija ljudskog genoma CXCL5 i stranica sa detaljima o genu CXCL5 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163735 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7929219-5] Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J Biol Chem. 269 (41): 25277–82. doi:10.1016/S0021-9258(18)47243-2. PMID 7929219.

[entrez-6] "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5".

[UniProt-7] "UniProt, P42830" (jezik: engleski). Pristupljeno 23. 10. 2021.

[Chang_1994-8] Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J. Biol. Chem. 269 (41): 25277–82. doi:10.1016/S0021-9258(18)47243-2. PMID 7929219.

[Persson_2003-9] Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). "Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils". Clin. Exp. Allergy. 33 (4): 531–7. doi:10.1046/j.1365-2222.2003.01609.x. PMID 12680872. S2CID 2449190.

[pmid10343098-10] O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

[Mei_2012-11] Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Bushman FD, Worthen GS (2012). "Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice". Journal of Clinical Investigation. 122 (3): 974–986. doi:10.1172/JCI60588. PMC 3287232. PMID 22326959.

[pmid21734176-12] Dawes JM, Calvo M, Perkins JR, Paterson KJ, Kiesewetter H, Hobbs C, Kaan TK, Orengo C, Bennett DL, McMahon SB (juli 2011). "CXCL5 Mediates UVB Irradiation-Induced Pain". Sci Transl Med. 3 (90): 90ra60. doi:10.1126/scitranslmed.3002193. PMC 3232447. PMID 21734176. Sažetak – FierceBiotech.

[Rousselle_2013-13] Rousselle A, Qadri F, Leukel L, Yilmaz R, Fontaine JF, Sihn G, Bader M, Ahluwalia A, Duchene J (2013). "CXCL5 limits macrophage foam cell formation in atherosclerosis". Journal of Clinical Investigation. 123 (3): 1343–7. doi:10.1172/JCI66580. PMC 3582141. PMID 23376791.

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