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TCS-1205
Names
	IUPAC name 2-(5-nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide
Identifiers
CAS Number	355022-97-8;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL75456;
ChemSpider	8490466;
PubChem CID	10315001;
	InChI Key: VCKKJKQZHHPPDR-LLVKDONJSA-N; InChI=1S/C18H15N3O4/c1-11(12-5-3-2-4-6-12)20-18(23)17(22)15-10-19-16-8-7-13(21(24)25)9-14(15)16/h2-11,19H,1H3,(H,20,23)/t11-/m1/s1;
	SMILES CC(C1=CC=CC=C1)NC(=O)C(=O)C2=CNC3=C2C=C(C=C3)[N+](=O)[O-];
Properties
Chemical formula	C18H15N3O4
Molar mass	337.335 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

TCS 1205 is an organic chemical compound. It is a benzodiazepine site agonist selective for certain sub-units.

Pharmacology

TCS 1205 acts at the benzodiazepine binding site, it is selective for the a1 and a2 subunits of the GABA_A receptor.^[1] In vivo, it has anxiolytic effects but no sedative effects.^[2]^[3]

Despite acting at the benzodiazepine receptor, it does not contain the benzodiazepine structure, it could therefore be classed as a Nonbenzodiazepine.

^ "TCS 1205" (PDF). Certificate of Analysis. Tocris Bioscience.
^ "TCS 1205". AbMole BioScience.
^ Taliani S, Cosimelli B, Da Settimo F, Marini AM, La Motta C, Simorini F, et al. (June 2009). "Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor". Journal of Medicinal Chemistry. 52 (12): 3723–3734. doi:10.1021/jm9001154. PMID 19469479.