(Suslin is also sometimes written with the French transliteration as Souslin, from the Cyrillic Суслин.)
Un ensemble ordonné (linéairement) sans sauts ni lacunes et tel que tout ensemble de ses intervalles (contenant plus qu'un élément) n'empiétant pas les uns sur les autres est au plus dénumerable, est-il nécessairement un continue linéaire (ordinaire)?
Is a (linearly) ordered set without jumps or gaps and such that every set of its intervals (containing more than one element) not overlapping each other is at most denumerable, necessarily an (ordinary) linear continuum?
The original statement of Suslin's problem from (Suslin 1920)
If the requirement for the countable chain condition is replaced with the requirement that R contains a countable dense subset (i.e., R is a separable space), then the answer is indeed yes: any such set R is necessarily order-isomorphic to R (proved by Cantor).
The condition for a topological space that every collection of non-empty disjoint open sets is at most countable is called the Suslin property.
Implications
Any totally ordered set that is not isomorphic to R but satisfies properties 1–4 is known as a Suslin line. The Suslin hypothesis says that there are no Suslin lines: that every countable-chain-condition dense complete linear order without endpoints is isomorphic to the real line. An equivalent statement is that every tree of height ω1 either has a branch of length ω1 or an antichain of cardinality ℵ1.
The generalized Suslin hypothesis says that for every infinite regular cardinalκ every tree of height κ either has a branch of length κ or an antichain of cardinality κ. The existence of Suslin lines is equivalent to the existence of Suslin trees and to Suslin algebras.
The Suslin hypothesis is independent of ZFC.
Jech (1967) and Tennenbaum (1968) independently used forcing methods to construct models of ZFC in which Suslin lines exist. Jensen later proved that Suslin lines exist if the diamond principle, a consequence of the axiom of constructibility V = L, is assumed. (Jensen's result was a surprise, as it had previously been conjectured that V = L implies that no Suslin lines exist, on the grounds that V = L implies that there are "few" sets.) On the other hand, Solovay & Tennenbaum (1971) used forcing to construct a model of ZFC without Suslin lines; more precisely, they showed that Martin's axiom plus the negation of the continuum hypothesis implies the Suslin hypothesis.
Solovay, R. M.; Tennenbaum, S. (1971), "Iterated Cohen Extensions and Souslin's Problem", Annals of Mathematics, 94 (2): 201–245, doi:10.2307/1970860, JSTOR1970860