SH3GL1

SH3GL1

Identifiers

SH3GL1, CNSA1, EEN, SH3D2B, SH3P8, SH3 domain containing GRB2 like 1, endophilin A2

External IDs

OMIM: 601768; MGI: 700010; HomoloGene: 55709; GeneCards: SH3GL1; OMA:SH3GL1 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	4,360,370 bp^[1]
Band	19p13.3	End	4,400,547 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 D\|17 29.11 cM	Start	56,323,750 bp^[2]
Band	17 D\|17 29.11 cM	End	56,343,635 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

skin of leg

skin of abdomen

mucosa of pharynx

ectocervix

stromal cell of endometrium

olfactory bulb

left adrenal cortex

right adrenal cortex

gastric mucosa

vagina

Top expressed in

spermatocyte

granulocyte

lip

yolk sac

calvaria

spermatid

esophagus

neural tube

embryo

internal carotid artery

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding identical protein binding lipid binding cadherin binding SH3 domain binding beta-1 adrenergic receptor binding transmembrane transporter binding protein C-terminus binding phosphatase binding GTPase binding
Cellular component	cytoplasm podosome cell junction endosome cell projection early endosome membrane membrane cytosol hippocampal mossy fiber to CA3 synapse synapse Schaffer collateral - CA1 synapse presynapse glutamatergic synapse postsynaptic density, intracellular component
Biological process	central nervous system development endocytosis signal transduction synaptic vesicle uncoating modulation of excitatory postsynaptic potential regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis
Sources:Amigo / QuickGO

Species

Human

Mouse


6455


20405


ENSG00000141985


ENSMUSG00000003200


Q99961 Q6FGM0


Q62419

RefSeq (mRNA)


NM_001199943 NM_001199944 NM_003025


NM_001252471 NM_013664 NM_001357649

RefSeq (protein)


NP_001186872 NP_001186873 NP_003016 NP_003016.1


NP_001239400 NP_038692 NP_001344578

Location (UCSC)

Chr 19: 4.36 – 4.4 Mb

Chr 17: 56.32 – 56.34 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141985 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003200 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
^ "Entrez Gene: SH3GL1 SH3-domain GRB2-like 1".

Further reading

So CW, Caldas C, Liu MM, et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. Bibcode:1997PNAS...94.2563S. doi:10.1073/pnas.94.6.2563. PMC 20128. PMID 9122235.
Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. Bibcode:1997PNAS...94.8569R. doi:10.1073/pnas.94.16.8569. PMC 23017. PMID 9238017.
Cestra G, Castagnoli L, Dente L, et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity". J. Biol. Chem. 274 (45): 32001–7. doi:10.1074/jbc.274.45.32001. PMID 10542231.
So CW, So CK, Cheung N, et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis". Leukemia. 14 (4): 594–601. doi:10.1038/sj.leu.2401692. PMID 10764144.
So CW, Sham MH, Chew SL, et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085. PMID 10816441.
Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID 11894096. S2CID 4389099.
Chatellard-Causse C, Blot B, Cristina N, et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yam JW, Jin DY, So CW, Chan LC (2004). "Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein". Blood. 103 (4): 1445–53. doi:10.1182/blood-2003-07-2452. hdl:10722/48499. PMID 14551139.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Liu H, Chen B, Xiong H, et al. (2004). "Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein". Oncogene. 23 (19): 3385–94. doi:10.1038/sj.onc.1207402. PMID 15077184.
Cheung N, So CW, Yam JW, et al. (2005). "Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia". Biochem. J. 383 (Pt 1): 27–35. doi:10.1042/BJ20040041. PMC 1134040. PMID 15214844.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yin X, Warner DR, Roberts EA, et al. (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.
Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell Sci. 118 (Pt 12): 2707–21. doi:10.1242/jcs.02383. PMID 15944398.
Ralser M, Nonhoff U, Albrecht M, et al. (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways". Hum. Mol. Genet. 14 (19): 2893–909. doi:10.1093/hmg/ddi321. hdl:11858/00-001M-0000-0010-85BB-5. PMID 16115810.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

Read other articles:

Dumingag, Zamboanga del Sur

Dumingag,_Zamboanga_del_Sur

Peta lokasi Dumingag Dumingag adalah munisipalitas yang terletak di provinsi Zamboanga del Sur, Filipina. Wilayah ini memiliki jumlah penduduk sebesar 46.039 jiwa. Dumingag terbagi menjadi 44 barangay. Bag-ong Valencia Bagong Kauswagan Bagong Silang Bucayan Calumanggi Canibongan Caridad Danlugan Dapiwak Datu Totocan Dilud Ditulan Dulian Dulop Guintananan Guitran Gumpingan La Fortuna Labangon Libertad Licabang Lipawan Lower Landing Lower Timonan Macasing Mahayahay Malagalad Manlabay Maralag Ma...

1968 Liberal Party of Australia leadership election

1968_Liberal_Party_of_Australia_leadership_election

Liberal Party of Australialeadership election, 1968 ← 1966 9 January 1968 1969 → Candidate John Gorton Paul Hasluck First ballot 35 (43.2%) 24 (29.6%) Second ballot 51 (63.0%) 30 (37.0%) Seat Senator (Vic.) Curtin (WA) Candidate Les Bury Billy Snedden First ballot 16 (19.8%) 6 (7.4%) Second ballot Eliminated Eliminated Seat Wentworth (NSW) Bruce (Vic.) Leader before election Harold Holt Elected Leader John Gorton A leadership election in the Liberal Party ...

Unione Sportiva Massese Aquilotti 1966-1967

Unione_Sportiva_Massese_Aquilotti_1966-1967

Voce principale: Unione Sportiva Massese 1919. Unione Sportiva Massese AquilottiStagione 1966-1967Sport calcio Squadra Massese Allenatore Mario Genta Presidente Angelo Tongiani Serie C7º posto nel girone B. Maggiori presenzeCampionato: Chinaglia (32) Miglior marcatoreCampionato: Rolla (8) 1965-1966 1967-1968 Si invita a seguire il modello di voce Questa pagina raccoglie le informazioni riguardanti l'Unione Sportiva Massese Aquilotti nelle competizioni ufficiali della stagione 1966-1967...

Haji Misbach

Artikel ini tidak memiliki referensi atau sumber tepercaya sehingga isinya tidak bisa dipastikan. Tolong bantu perbaiki artikel ini dengan menambahkan referensi yang layak. Tulisan tanpa sumber dapat dipertanyakan dan dihapus sewaktu-waktu.Cari sumber: Haji Misbach – berita · surat kabar · buku · cendekiawan · JSTOR Haji MisbachHaji Mohamad MisbachLahirAhmad1876Kauman, Surakarta, Hindia BelandaMeninggal24 Mei 1926(1926-05-24) (umur 49–50)Manokwa...

List of personal aides to the president of the United States

List_of_personal_aides_to_the_president_of_the_United_States

Personal assistants to the President of the US Reggie Love, left, Barack Obama's body man from 2009 to 2011, is seen here in a presidential motorcade outside Strasbourg for the 2009 NATO summit A personal assistant[1] who accompanies the president of the United States virtually everywhere is generally referred to as a body man or body woman, but in some cases may be referred to as a personal aide. These personal aides to the president are often responsible for arranging and providing:...

Pirang

Pesepakbola Lars Unnerstall, yang memiliki rambut pirang dan janggut pirang Gadis berambut pirang dari Vanuatu Peta rambut pirang karangan antropolog Peter Frost. Di daerah kuning paling cerah, rambut pirang paling umum (80% atau lebih). Makin gelap warna, makin sedikit jumlah orang berambut pirangnya. Di daerah yang diwarnai hitam, tidak ada orang berambut pirang. Pirang atau kuning bambu merupakan warna rambut yang timbul akibat kurangnya pigmen eumelanin. Biasanya warna rambut ini diwarisk...

Ivan (footballer, born 1997)

Ivan_(footballer,_born_1997)

Brazilian footballer In this Portuguese name, the first or maternal family name is Quaresma and the second or paternal family name is da Silva. Ivan Ivan with Zenit St. Petersburg in 2022Personal informationFull name Ivan Quaresma da SilvaDate of birth (1997-02-07) 7 February 1997 (age 27)Place of birth Rio das Pedras, São Paulo, BrazilHeight 1.96 m (6 ft 5 in)Position(s) GoalkeeperTeam informationCurrent team InternacionalNumber 22Youth career Guarani2013–2017 Pont...

Gitanas Nausėda

Gitanas_Nausėda

Gitanas Nausėda Presiden LituaniaPetahanaMulai menjabat 12 Juli 2019Perdana MenteriSaulius SkvernelisIngrida ŠimonytėPendahuluDalia GrybauskaitėPenggantiPetahana Informasi pribadiLahir19 Mei 1964 (umur 59)Klaipėda, LituaniaPartai politikIndependenSuami/istriDiana NepaitėPendidikanUniversitas VilniusTanda tanganSunting kotak info • L • B Gitanas Nausėda (lahir 19 Mei 1964) adalah seorang politikus asal Lituania yang saat ini menjabat sebagai Presiden Lituania seja...

Club Deportivo Nacional

Club_Deportivo_Nacional

Mexican association football club Football clubNacionalFull nameClub Deportivo Nacional, A. C.Nickname(s)Pericos (parrots)Founded1916 [1]GroundClub Deportivo ImperioZapopan, Jalisco, MexicoCapacity500ChairmanJosé Alberto Cortés GarcíaManagerLuis Octavio TorresLeagueLiga TDP – Group XII2020–2120th – Group X Home colours Away colours Club Deportivo Nacional is a Mexican football team founded in Guadalajara, Jalisco, México in 1916. The club won its first title in 192...

خط عرض 29° شمال

خط_عرض_29°_شمال

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (ديسمبر 2018) 29° خط عرض 29 شمال خريطة لجميع الإحداثيات من جوجل خريطة لجميع الإحداثيات من بينغ تصدير جميع الإحداثيات من ك...

Green Lantern: Rise of the Manhunters

Green_Lantern:_Rise_of_the_Manhunters

2011 video gameGreen Lantern: Rise of the ManhuntersXbox 360 and PlayStation 3 cover artDeveloper(s)Double Helix Games(non-Nintendo consoles)Griptonite Games[1](Nintendo versions)Publisher(s)Warner Bros. Interactive Entertainment[1]Director(s)David MsikaDesigner(s)Benjamin CholewinskiProgrammer(s)Carlos BustamanteArtist(s)David Robert DonatucciWriter(s)Marv Wolfman[2]Composer(s)Kaveh CohenMichael David NielsenPlatform(s)PlayStation 3, Xbox 360, Wii, Nintendo DS, Ninten...

History of Romania

History_of_Romania

Romanian History Part of a series on the History of Romania Prehistory Cucuteni–Trypillia culture Hamangia culture Bronze Age in Romania Prehistory of Transylvania Antiquity Dacia Dacian Wars Roman Dacia Origin of the Romanians Middle Ages (Early) History of Transylvania Banat in the Middle Ages First Bulgarian Empire Second Bulgarian Empire Voivodeship of Maramureș Founding of Wallachia Founding of Moldavia Rumelia Eyalet Early Modern Times Silistra Eyalet Principality of Transylvania Eya...

Powerlifting

Sport PowerliftingThe deadlift being performed by 2009 IPF World Champion Dean BowringFirst played20th century or earlier, United StatesCharacteristicsTypeInternational Powerlifting Federation (IPF) weight classes: Women: 47 kg, 52 kg, 57 kg, 63 kg, 69 kg, 76 kg, 84 kg, 84 kg+ Men: 59 kg, 66 kg, 74 kg, 83 kg, 93 kg, 105 kg, 120 kg, 120 kg+ PresenceOlympicNoParalympic1964 – presentWorld Games1981...

George County, Mississippi

George_County,_Mississippi

County in Mississippi, United States County in MississippiGeorge CountyCountyGeorge County courthouse in LucedaleLocation within the U.S. state of MississippiMississippi's location within the U.S.Coordinates: 30°52′N 88°38′W / 30.87°N 88.64°W / 30.87; -88.64Country United StatesState MississippiFounded1910Named forJames Z. GeorgeSeatLucedaleLargest cityLucedaleArea • Total484 sq mi (1,250 km2) • Land479 sq&#...

Basilicas in the Catholic Church

Basilicas_in_the_Catholic_Church

Ceremonial designation of church buildings For a list of all the Catholic basilicas in the world, see List of Catholic basilicas. Floorplan of San Lorenzo in Damaso, a basilica in Rome. It is built in the basilica style: a rectangular building with a nave flanked by longitudinal aisles. Basilicas are Catholic church buildings that have a designation, conferring special privileges, given by the Pope. Basilicas are distinguished for ceremonial purposes from other churches. The building need not...

Portrait of a Man in a Red Cap

Portrait_of_a_Man_in_a_Red_Cap

Painting by Titian Man in a Red CapArtistTitianYearc. 1510–1516 (c. 1510–1516)MediumOil on canvasDimensions82.2 cm × 71.1 cm (32.4 in × 28.0 in)LocationFrick Collection, New York City Portrait of a Man in a Red Cap, also known as Man with a Red Cap,[1] is an oil painting by the Venetian painter Titian, made in about 1516. It is part of the Frick Collection in New York City. Date Two portraits of young men have been ascri...

Merangin Regency

Merangin_Regency

Regency in Jambi, IndonesiaMerangin Regency Kabupaten MeranginRegency Coat of armsMotto(s): Tali Undang Tambang Teliti (Strap of Penghulu tribe and rope of Batin tribe; another meaning: tie in the rules, explore carefully)CountryIndonesiaProvinceJambiRegency seatBangkoArea • Total7,679.0 km2 (2,964.9 sq mi)Population (mid 2023 estimate)[1] • Total368,389 • Density48/km2 (120/sq mi)Time zoneUTC+7 (WIB)Websitemeranginkab....

Paray-sous-Briailles

Paray-sous-Briailles

Cet article est une ébauche concernant une commune de l’Allier. Vous pouvez partager vos connaissances en l’améliorant (comment ?). Le bandeau {{ébauche}} peut être enlevé et l’article évalué comme étant au stade « Bon début » quand il comporte assez de renseignements encyclopédiques concernant la commune. Si vous avez un doute, l’atelier de lecture du projet Communes de France est à votre disposition pour vous aider. Consultez également la page d’aide ...

Nhân thần kinh hạ thiệt

Nhân_thần_kinh_hạ_thiệt

Nhân thần kinh hạ thiệtNhân hạ thiệtThiết đồ cắt qua hành tủy. (Nhân hạ thiệt, Hypoglossal nucleus ở phía trên và bên trái.)Các nhân thần kinh sọ theo sơ đồ nhìn từ đằng sau. Nhân vận động màu đỏ; nhân cảm giác màu xanh lam. (thần kinh XII ở phía dưới, bên trái.)Chi tiếtĐịnh danhLatinhnucleus nervi hypoglossiNeuroName757NeuroLex IDbirnlex_2644TAA14.1.04.227FMA54505Thuật ngữ giải phẫu thần kinh[Chỉn...

Maxillary first premolar

Maxillary_first_premolar

Human tooth Maxillary first premolarMaxillary first premolarMaxillary first premolarIdentifiersFMA55801Anatomical terminology[edit on Wikidata] The maxillary first premolar is one of two teeth located in the upper jaw, laterally (away from the midline of the face) from both the maxillary canines of the mouth but mesial (toward the midline of the face) from both maxillary second premolars. The function of this premolar is similar to that of canines in regard to tearing being the principal ...