RHOB
Protein-coding gene in the species Homo sapiens
Ras homolog gene family, member B , also known as RHOB , is a protein which in humans is encoded by the RHOB gene .[ 5] [ 6]
RHOB is a member of the Rho GTP-binding protein family.[ 7]
Interactions
RHOB has been shown to interact with CIT ,[ 8] ARHGEF3 ,[ 9] ARHGDIG [ 10] RHPN2 .[ 11]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000143878 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054364 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: RHOB ras homolog gene family, member B" .^ Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9" . Nucleic Acids Research . 16 (6): 2717. doi :10.1093/nar/16.6.2717 . PMC 336400 PMID 3283705 . ^ Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)" . Journal of Cell Science . 117 (Pt 8): 1301–12. doi :10.1242/jcs.01118 PMID 15020670 . ^ Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S (December 1995). "A novel partner for the GTP-bound forms of rho and rac" . FEBS Letters . 377 (2): 243–8. doi :10.1016/0014-5793(95)01351-2 PMID 8543060 . ^ Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (November 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC" . The Journal of Biological Chemistry . 277 (45): 42964–72. doi :10.1074/jbc.M207401200 PMID 12221096 . ^ Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG" . The Journal of Biological Chemistry . 271 (48): 30366–74. doi :10.1074/jbc.271.48.30366 PMID 8939998 . ^ Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF) . European Journal of Biochemistry . 269 (24): 6241–9. doi :10.1046/j.1432-1033.2002.03343.x . PMID 12473120 . S2CID 23901713 .
Further reading
Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE (January 2011). "RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice" . The American Journal of Pathology . 178 (1): 245–52. doi :10.1016/j.ajpath.2010.11.040 . PMC 3069827 PMID 21224061 . Casey PJ, Seabra MC (March 1996). "Protein prenyltransferases" . The Journal of Biological Chemistry . 271 (10): 5289–92. doi :10.1074/jbc.271.10.5289 PMID 8621375 . Adamson P, Marshall CJ, Hall A, Tilbrook PA (October 1992). "Post-translational modifications of p21rho proteins" . The Journal of Biological Chemistry . 267 (28): 20033–8. doi :10.1016/S0021-9258(19)88661-1 PMID 1400319 . Cannizzaro LA, Madaule P, Hecht F, Axel R, Croce CM, Huebner K (February 1990). "Chromosome localization of human ARH genes, a ras-related gene family". Genomics . 6 (2): 197–203. doi :10.1016/0888-7543(90)90557-B . PMID 2407642 . Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9" . Nucleic Acids Research . 16 (6): 2717. doi :10.1093/nar/16.6.2717 . PMC 336400 PMID 3283705 . Madaule P, Axel R (May 1985). "A novel ras-related gene family". Cell . 41 (1): 31–40. doi :10.1016/0092-8674(85)90058-3 . PMID 3888408 . S2CID 32708060 . Robertson D, Paterson HF, Adamson P, Hall A, Monaghan P (May 1995). "Ultrastructural localization of ras-related proteins using epitope-tagged plasmids" . The Journal of Histochemistry and Cytochemistry . 43 (5): 471–80. doi :10.1177/43.5.7537292 PMID 7537292 . Armstrong SA, Hannah VC, Goldstein JL, Brown MS (April 1995). "CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB" . The Journal of Biological Chemistry . 270 (14): 7864–8. doi :10.1074/jbc.270.14.7864 PMID 7713879 . Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG" . The Journal of Biological Chemistry . 271 (48): 30366–74. doi :10.1074/jbc.271.48.30366 PMID 8939998 . Mellor H, Flynn P, Nobes CD, Hall A, Parker PJ (February 1998). "PRK1 is targeted to endosomes by the small GTPase, RhoB" . The Journal of Biological Chemistry . 273 (9): 4811–4. doi :10.1074/jbc.273.9.4811 PMID 9478917 . Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 5 (3): 169–76. doi :10.1093/dnares/5.3.169 PMID 9734811 . Liu JP, Jessell TM (December 1998). "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube". Development . 125 (24): 5055–67. doi :10.1242/dev.125.24.5055 . PMID 9811589 . Gampel A, Parker PJ, Mellor H (September 1999). "Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB" . Current Biology . 9 (17): 955–8. Bibcode :1999CBio....9..955G . doi :10.1016/S0960-9822(99)80422-9 PMID 10508588 . S2CID 9616910 . Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S, Malorni W (January 2000). "The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly" . Cell Death and Differentiation . 7 (1): 25–36. doi :10.1038/sj.cdd.4400616 PMID 10713718 . Liu Ax, Du W, Liu JP, Jessell TM, Prendergast GC (August 2000). "RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors" . Molecular and Cellular Biology . 20 (16): 6105–13. doi :10.1128/MCB.20.16.6105-6113.2000 . PMC 86086 PMID 10913192 . Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR (January 2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding" . The Journal of Cell Biology . 152 (1): 111–26. doi :10.1083/jcb.152.1.111 . PMC 2193662 PMID 11149925 . Cerniglia GJ, Bernhard EJ, Prendergast GC (May 2001). "RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage" . Proceedings of the National Academy of Sciences of the United States of America . 98 (11): 6192–7. Bibcode :2001PNAS...98.6192L . doi :10.1073/pnas.111137198 PMC 33444 PMID 11353846 . Diviani D, Soderling J, Scott JD (November 2001). "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation" . The Journal of Biological Chemistry . 276 (47): 44247–57. doi :10.1074/jbc.M106629200 PMID 11546812 . Adnane J, Seijo E, Chen Z, Bizouarn F, Leal M, Sebti SM, Muñoz-Antonia T (March 2002). "RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1" . The Journal of Biological Chemistry . 277 (10): 8500–7. doi :10.1074/jbc.M104367200 PMID 11741970 .
