Peter N. Devreotes

Peter Nicholas Devreotes
CitizenshipUnited States
Alma materUniversity of Wisconsin–Madison, Johns Hopkins University
Known forEukaryotic chemotaxis, Signal transduction, Phosphoinositides biology
SpouseAline Devreotes
AwardsE.B. Wilson Medal(2019),[1][2][3] American Society for Cell Biology Inaugural Lifetime fellow (2016),[4][5] Member of the National Academy of Sciences (2005)[6][7][8]
Scientific career
FieldsCell biology, biophysics, systems biology
InstitutionsJohns Hopkins School of Medicine[9]
Doctoral advisorDouglas M. Fambrough, PhD
Notable studentsRobert Insall
Websitedevreotes.johnshopkins.edu

Peter N. Devreotes is an American scientist and the Isaac Morris & Lucille Elizabeth Hay Professor[10][11] and former director of the department of cell biology,[1][8] with joint appointments in the Center for Cell Dynamics[12] and department of biological chemistry[13] at the Johns Hopkins University School of Medicine.[9] He also serves on the scientific advisory board of the Allen Institute for Cell Science.[14] He is best known for his contribution in the field of eukaryotic chemotaxis, signal transduction, and phosphoinositides biology.[1][6][7][15]

Education and career

Devreotes received his Bachelor of Science degree in physics from University of Wisconsin–Madison in 1971. He next earned his PhD degree in biophysics from the Johns Hopkins University in 1977, where he worked in the laboratory of Dr Douglas Fambrough. He then carried his post-doctoral research in Dr Theodore Steck laboratory at the University of Chicago. Devreotes started his independent career as an assistant professor at the department of biological chemistry]in the Johns Hopkins University School of Medicine in 1980. He was subsequently promoted to the rank of associate professor and then to professor. He served as the director of the biochemistry and molecular biology graduate program from 1990 to 2000. Then he was appointed as the director of the department of cell biology of the Johns Hopkins University School of Medicine in 2000.[9][16][17]

As an internationally recognized leader in cell migration, Devreotes was elected to the National Academy of Sciences.[7] He was elected and served as a council member of American Society for Cell Biology.[18] He served in the advisory of the Searle Scholars Program.[19] Devreotes founded Gordon Research Conference on "Gradient Sensing and Directed Cell Migration" in 2005.[20] He currently serves on the Scientific Advisory Board of the Allen Institute for Cell Science.[14]

Devreotes trained more than 75 doctoral students and post-doctoral fellows, many of whom have received senior and distinguished positions in major research institutes (such as University of Michigan, Perelman School of Medicine, Johns Hopkins University, Beatson institute, UTSW, Weill Cornell Medicine, NIAID ) and in different industry.[17][better source needed] He authored more than 300 scholastic publications including research articles, reviews, book chapters. As of June 2023, he has an h-index of 94 on Google Scholar.[21]

Research

Devreotes is an internationally recognized leader in the field of chemotaxis and signal transduction.[7][11][14] Devreotes was the first to identify the chemoattractant receptors and to demonstrate that multiple signalling events are activated asymmetrically at the cells leading edge which led to an understanding of the sophisticated strategies that cells use to precisely sense direction.[7][22] Subsequent research in Devreotes lab helped to uncover the GPCR kinetics and phosphoinositides biology of the polarity organization in migrating Dictyostelium and leukocyte cells.[23][24] Inside the scientific community, he is widely credited for bringing system-level understanding and implementing computational analysis of dynamical systems in different cell physiological processes.[1] His recent works[as of?] focus on the understanding the dynamics of internal feedback loops in signal transduction and cytoskeletal networks that confer the biochemical excitability to the membrane and thus control different morphological and functional properties of the cell.[1][2][25][26]

Awards and honours

Devreotes received several major awards and honors for his contribution to the cell biology and systems biology:

References

  1. ^ a b c d e f Spiro, Mary. "2019 E. B. Wilson Medalist Peter Devreotes tells the story of chemotaxis". American Society for Cell Biology. Retrieved September 2, 2021.
  2. ^ a b c Devreotes, Peter (November 1, 2019). "Moving toward molecular mechanisms for chemotaxis in eukaryotic cells". Molecular Biology of the Cell. 30 (23): 2873–2877. doi:10.1091/mbc.E19-07-0393. PMC 6822590. PMID 31671039.
  3. ^ a b "Johns Hopkins Cell Biologist Wins Professional Association's Highest Honor". Johns Hopkins Medicine. October 1, 2019. Retrieved September 2, 2021.
  4. ^ a b YokoCo (November 7, 2016). "ASCB Elects 39 to Lifetime Achievement Fellows Program". American Society for Cell Biology. Retrieved September 2, 2021.
  5. ^ a b "Peter Devreotes". American Society for Cell Biology. Retrieved September 2, 2021.
  6. ^ a b c Nair, Prashant (November 16, 2010). "QnAs with Peter N. Devreotes". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19613. Bibcode:2010PNAS..10719613N. doi:10.1073/pnas.1014645107. PMC 2993395. PMID 20956300.
  7. ^ a b c d e f "Peter N. Devreotes". Member Directory. National Academy of Sciences. Retrieved September 2, 2021.
  8. ^ a b c De Nike, Lisa (May 3, 2005). "TWO JOHNS HOPKINS SCIENTISTS ELECTED TO NATIONAL ACADEMY OF SCIENCES". Johns Hopkins Medicine. Retrieved September 2, 2021.
  9. ^ a b c "Peter N. Devreotes, Ph.D." Johns Hopkins Medicine. Retrieved September 2, 2021.
  10. ^ a b "Hay Professorship". Department of Cell Biology. Johns Hopkins University School of Medicine. Retrieved September 2, 2021.
  11. ^ a b c "Isaac Morris and Lucille Elizabeth Hay Professorship in Embryology". Johns Hopkins University. Retrieved September 2, 2021.
  12. ^ "Faculty – Center for Cell Dynamics". Johns Hopkins University. Retrieved September 2, 2021.
  13. ^ "Secondary Appoinmnets". Johns Hopkins Medicine.
  14. ^ a b c "Peter Devreotes, Ph.D. Johns Hopkins University School of Medicine". Allen Institute. Retrieved September 2, 2021.
  15. ^ Kolf, Catherine. "Peter Devreotes on Cell Movement". Johns Hopkins Medicine. Retrieved September 2, 2021.
  16. ^ "Devreotes New Biosketch" (PDF). Johns Hopkins Medicine. Retrieved September 2, 2021.
  17. ^ a b "About PI – Peter N Devreotes Laboratory". Johns Hopkins University School of Medicine. Retrieved September 2, 2021.
  18. ^ Clarke, Thea (June 6, 2016). "Nunnari Elected President for 2018". American Society for Cell Biology. Retrieved September 2, 2021.
  19. ^ "Peter N. Devreotes – Searle Scholars Program". Searle Scholars Program. Retrieved September 2, 2021.
  20. ^ "Directed Cell Migration Gordon Research Conference". Gordon Research Conference. Retrieved September 2, 2021.
  21. ^ "Peter Devreotes, Professor of Cell Biology". Google Scholar. Retrieved June 11, 2023.
  22. ^ Marí-Beffa, Manuel (March 24, 2005). Key Experiments in Practical Developmental Biology. Cambridge University Press. p. 64. ISBN 9780521833158. Retrieved September 2, 2021.
  23. ^ Segall, Jeffrey E (January 28, 1999). "Cell polarization: Chemotaxis gets CRACking" (PDF). Current Biology. 9 (2). Cell Press: R46-8. Bibcode:1999CBio....9..R46S. doi:10.1016/s0960-9822(99)80007-4. PMID 10021352. Retrieved September 2, 2021.
  24. ^ Parent, C A; Devreotes, P N (April 30, 1999). "A cell's sense of direction". Science. 284 (5415): 765–70. Bibcode:1999Sci...284..765P. doi:10.1126/science.284.5415.765. PMID 10221901. Retrieved September 2, 2021.
  25. ^ Devreotes, Peter N (October 6, 2017). "Excitable Signal Transduction Networks in Directed Cell Migration". Annual Review of Cell and Developmental Biology. 33: 103–125. doi:10.1146/annurev-cellbio-100616-060739. PMC 5792054. PMID 28793794.
  26. ^ Wu, Min; Liu, Jian (February 2021). "Mechanobiology in cortical waves and oscillations". Current Opinion in Cell Biology. 68: 45–54. doi:10.1016/j.ceb.2020.08.017. ISSN 0955-0674. PMID 33039945. S2CID 222302897.
  27. ^ "Signaling Networks in Chemotaxis and Cytokinesis". National Institutes of Health. Retrieved September 2, 2021.