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Naftidrofuryl
Clinical data
Trade names	Praxilene
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	C04AX21 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	1 - 3.5 hours
Identifiers
	IUPAC name (RS)-2-(diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydrofuran-2-ylmethyl)propanoate;
CAS Number	31329-57-4 ;
PubChem CID	4417;
ChemSpider	4264 ;
UNII	42H8PQ0NMJ;
ChEMBL	ChEMBL1620794;
CompTox Dashboard (EPA)	DTXSID3023344 ;
ECHA InfoCard	100.045.960
Chemical and physical data
Formula	C24H33NO3
Molar mass	383.532 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCN(CC)CC)C(Cc2c1ccccc1ccc2)CC3OCCC3;
	InChI InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3 ; Key:KBAFPSLPKGSANY-UHFFFAOYSA-N ;
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Naftidrofuryl (INN), also known as nafronyl or as the oxalate salt naftidrofuryl oxalate or nafronyl oxalate, is a vasodilator used in the management of peripheral and cerebral vascular disorders. It is also claimed to enhance cellular oxidative capacity. The drug act as a selective antagonist of 5-HT₂ receptors (with action as an inverse agonist of the 5-HT_2A receptor specifically characterized).^[1]^[2]^[3] Naftidrofuryl is also licensed for the treatment of intermittent claudication due to peripheral arterial disease.

Naftidrofuryl is marketed under a variety of trade names, including Artocoron, Azunaftil, Di-Actane, Dusodril, Enelbin, Frilix, Gevatran, Iridus, Iridux, Luctor, Nafti, Naftilong, Naftodril, Nafoxal, Praxilene, Sodipryl retard, and Vascuprax.

Historically, it has been used to treat sudden idiopathic hearing loss and acute tinnitus.^[4]

Naftidrofuryl may be effective for relieving the pain of muscle cramps.^[5]