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CP-94253
Identifiers
	IUPAC name 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine;
CAS Number	131084-35-0 ;
PubChem CID	4029677;
IUPHAR/BPS	3221;
ChemSpider	3246572 ;
CompTox Dashboard (EPA)	DTXSID10470073 ;
Chemical and physical data
Formula	C15H19N3O
Molar mass	257.337 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c13nc(OCCC)ccc1[nH]cc3C2=CCNCC2;
	InChI InChI=1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3 ; Key:KWQWBZIGHIOKIO-UHFFFAOYSA-N ;
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CP-94253 is a drug which acts as a potent and selective serotonin 5-HT_1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT_1D and 5-HT_1A receptors.^[1] It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain;^[2]^[3] reducing food intake and promoting satiety;^[4]^[5]^[6] enhancing the reinforcing effects of cocaine;^[7]^[8]^[9]^[10] and possible antidepressant effects.^[11] A recent study^[12] found that "Regardless of sex, CP94253 decreased cocaine intake after abstinence and during resumption of SA [self-administration] and decreased cue reactivity" suggesting that agonism of the inhibitory 5-HT2B receptors may diminish the cognitive reward of cocaine usage and increased use of the drug without a period of abstinence may be a product of test subjects trying to achieve a previously rewarding experience through larger dosages of cocaine.

References

^ Koe KB, Nielsen JA, Macor JE, Heym J (1992). "Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253". Drug Development Research. 26 (3): 241–250. doi:10.1002/ddr.430260305. S2CID 85358992.
^ Monti JM, Monti D, Jantos H, Ponzoni A (December 1995). "Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat". Neuropharmacology. 34 (12): 1647–1651. doi:10.1016/0028-3908(95)00112-3. PMID 8788962. S2CID 11872727.
^ Iyer RN, Bradberry CW (April 1996). "Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization". The Journal of Pharmacology and Experimental Therapeutics. 277 (1): 40–47. PMID 8613947.
^ Halford JC, Blundell JE (September 1996). "The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence". Physiology & Behavior. 60 (3): 933–939. doi:10.1016/0031-9384(96)00073-x. PMID 8873272. S2CID 24349948.
^ Lee MD, Simansky KJ (June 1997). "CP-94, 253: a selective serotonin1B (5-HT1B) agonist that promotes satiety". Psychopharmacology. 131 (3): 264–270. doi:10.1007/s002130050292. PMID 9203237. S2CID 33969765.
^ Lee MD, Kennett GA, Dourish CT, Clifton PG (October 2002). "5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253". Psychopharmacology. 164 (1): 49–60. doi:10.1007/s00213-002-1162-7. PMID 12373419. S2CID 2926575.
^ Parsons LH, Weiss F, Koob GF (December 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". The Journal of Neuroscience. 18 (23): 10078–10089. doi:10.1523/JNEUROSCI.18-23-10078.1998. PMC 6793270. PMID 9822762.
^ Przegalinski E, Filip M, Papla I, Siwanowicz J (April 2001). "Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats". Behavioural Pharmacology. 12 (2): 109–116. doi:10.1097/00008877-200104000-00004. PMID 11396515.
^ Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (March 2007). "Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats". European Journal of Pharmacology. 559 (2–3): 165–172. doi:10.1016/j.ejphar.2006.12.012. PMID 17291490.
^ Przegaliński E, Gołda A, Filip M (2008). "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports. 60 (6): 798–810. PMID 19211971.
^ Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E (May 2005). "Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action". European Journal of Pharmacology. 516 (1): 46–50. doi:10.1016/j.ejphar.2005.04.025. PMID 15913599.
^ Scott SN, Garcia R, Powell GL, Doyle SM, Ruscitti B, Le T, et al. (October 2021). "5-HT_1B receptor agonist attenuates cocaine self-administration after protracted abstinence and relapse in rats". Journal of Psychopharmacology. 35 (10): 1216–1225. doi:10.1177/02698811211019279. PMID 34049460. S2CID 235243643.