Mir-885 microRNA precursor family

mir-885
Identifiers
Symbolmir-885
RfamRF01015
miRBase familyMIPF0000532
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-885 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-885-5p in neuroblastoma

The miR-885-5p form of this microRNA acts as a tumour suppressor in neuroblastoma, through interference with cell cycle progression and cell survival. It is found at 3p25.3, a chromosome region frequently deleted in primary neuroblastoma,[1] and expression results in p53 protein accumulation and pathway activation. Altered expression of multiple genes is observed with miR-885-5p, including the CDK2 and MCM5 genes encoding cyclin-dependent kinase 2 and mini-chromosome maintenance protein MCM5, and also with several p53 target genes.[1]

Biological Implication

Clinical Biomarker

Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions. similarly, miR-885-5p found as a potential marker for liver disease condition. It is significantly elevated in the patients sera with liver pathologies, and researcher suggested that serum miRNAs could serve as novel complementary biomarkers for the detection and assessment of liver pathologies.[2] These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in colorectal cancer (CRC). The direct comparison of expression patterns of metastasis-specific microRNAs (miRNAs) in primary CRCs (pCRCs) and matched liver metastases (LMs) provides a feasibility of their clinical application as metastasis-specific biomarkers.[3] In a clinical study it has been found that miR-885-5p is increased in plasma from pre-eclampsia compared with healthy pregnant women, and it is released into circulation mainly inside exosomes.[4]

Cancer

In search of an effective therapeutic strategy for improving colon cancer treatment, a novel role of miR-885-3p has been observed in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor, and provide new evidence that targeting miRNAs might be an effective therapeutic strategy.[5]

See also

References

  1. ^ a b Afanasyeva EA, Mestdagh P, Kumps C, Vandesompele J, Ehemann V, Theissen J, et al. (2011). "MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival". Cell Death Differ. 18 (6): 974–84. doi:10.1038/cdd.2010.164. PMC 3131937. PMID 21233845.
  2. ^ Gui, Junhao; Tian, Yaping; Wen, Xinyu; Zhang, Wenhui; Zhang, Pengjun; Gao, Jing; Run, Wei; Tian, Liyuan; Jia, Xingwang (2011-03-01). "Serum microRNA characterization identifies miR-885-5p as a potential marker for detecting liver pathologies". Clinical Science. 120 (5): 183–193. doi:10.1042/CS20100297. ISSN 1470-8736. PMC 2990200. PMID 20815808.
  3. ^ Hur, Keun; Toiyama, Yuji; Schetter, Aaron J.; Okugawa, Yoshinaga; Harris, Curtis C.; Boland, C. Richard; Goel, Ajay (March 2015). "Identification of a metastasis-specific MicroRNA signature in human colorectal cancer". Journal of the National Cancer Institute. 107 (3). doi:10.1093/jnci/dju492. ISSN 1460-2105. PMC 4334826. PMID 25663689.
  4. ^ Sandrim, V. C.; Luizon, M. R.; Palei, A. C.; Tanus-Santos, J. E.; Cavalli, R. C. (December 2016). "Circulating microRNA expression profiles in pre-eclampsia: evidence of increased miR-885-5p levels". BJOG: An International Journal of Obstetrics and Gynaecology. 123 (13): 2120–2128. doi:10.1111/1471-0528.13903. ISSN 1471-0528. PMID 26853698.
  5. ^ Xiao, F.; Qiu, H.; Cui, H.; Ni, X.; Li, J.; Liao, W.; Lu, L.; Ding, K. (2015-04-09). "MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling". Oncogene. 34 (15): 1968–1978. doi:10.1038/onc.2014.134. ISSN 1476-5594. PMID 24882581.

Further reading


Stub icon

This genetics article is a stub. You can help Wikipedia by expanding it.

Read other articles:

Усатовская культура

Усатовская культураранний бронзовый век Локализация Болгария, Молдавия, Румыния, Сербия, Украина Датировка 3500—3000 гг. до н. э. Носители палеобалканцы Преемственность ←Чернаводэ → Витенбергская→ Монтеору→  Медиафайлы на Викискладе Усатовская культура (от ук...

 

 

kanji

Untuk kegunaan lain, lihat Kanji (disambiguasi). KanjiJenis aksara Logogram BahasaJepang Kuno, JepangArah penulisanKiri ke kananAksara terkaitSilsilahAksara tulang ramalanAksara segelAksara juru tulisKaishuKanjiAksara kerabatHanja, Zhuyin, Hanzi sederhana, Chu Nom, Aksara Khitan, Aksara JurchenISO 15924ISO 15924Hani, , ​Han (Hanzi, Kanji, Hanja)Pengkodean UnicodeNama UnicodeHan Artikel ini mengandung transkripsi fonetik dalam Alfabet Fonetik Internasional (IPA). Untuk ban...

 

 

Islam di Kenya

Islam menurut negara Afrika Aljazair Angola Benin Botswana Burkina Faso Burundi Kamerun Tanjung Verde Republik Afrika Tengah Chad Komoro Republik Demokratik Kongo Republik Kongo Djibouti Mesir Guinea Khatulistiwa Eritrea Eswatini Etiopia Gabon Gambia Ghana Guinea Guinea-Bissau Pantai Gading Kenya Lesotho Liberia Libya Madagaskar Malawi Mali Mauritania Mauritius Maroko Mozambik Namibia Niger Nigeria Rwanda Sao Tome dan Principe Senegal Seychelles Sierra Leone Somalia Somaliland Afrika Selatan ...

PrvaLiga Slovenia

PrvaLiga SloveniaBadan yang mengaturAsosiasi Sepak Bola SloveniaNegaraSloveniaKonfederasiUEFADibentuk1991; 33 tahun lalu (1991)Jumlah tim10Tingkat pada piramida1Degradasi ke2. SNLPiala domestikSlovenia CupPiala internasionalUEFA Champions LeagueUEFA Europa Conference LeagueJuara bertahan ligaOlimpija Ljubljana (3 gelar) (2022–23)Klub tersuksesMaribor (16 gelar)Pencetak gol terbanyakMarcos Tavares (159)Televisi penyiarSportklubŠport TVSitus webprvaliga.si 2023–24 Slovenian PrvaLiga P...

 

 

S.O.S. Eisberg

1933 filmS.O.S. EisbergGerman theatrical release posterDirected byArnold FanckTay Garnett (U.S. version)Written byEdwin H. KnopfScreenplay byTom ReedStory byArnold FanckFriedrich Wolf (uncredited)Produced by Carl Laemmle Jr. Paul Kohner Starring Gustav Diessl Leni Riefenstahl Sepp Rist Gibson Gowland Ernst Udet Rod La Rocque Walter Riml Cinematography Richard Angst Hans Schneeberger Edited by Hermann Haller Andrew Marton Music byPaul DessauProductioncompanyDeutsche Universal-FilmDistributed b...

 

 

Algeria national football team

Men's association football team This article is about the men's team. For the women's team, see Algeria women's national football team. AlgeriaNickname(s)الخُضر (The Greens)[1] الأفناك  (The Fennec foxes)[2]مُحَارِبِي الصَّحْرَاء  (The Desert Warriors)[3]AssociationAlgerian Football Federation (FAF)ConfederationCAF (Africa)Sub-confederationUNAF (North Africa)Head coachVladimir PetkovićCaptainYacine BrahimiMost capsIslam Slim...

National symbols of Switzerland

National symbols of Switzerland are the symbols used to represent Switzerland. As of 2020 the Swiss legislature has made three Swiss national symbols official, a flag, coat of arms, and anthem, but various other symbols are used as well to represent the Swiss people. Official national symbols Symbol Image Notes National flag Flag of Switzerland [1][2] Current design in official use since 1841 National coat of arms Coat of Arms of Switzerland [3] Current design in offic...

 

 

Soyuz-M

This article is about the Soyuz-M rocket. For other Soyuz variants, see Soyuz (rocket family). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Soyuz-M – news · newspapers · books · scholar · JSTOR (December 2009) (Learn how and when to remove this message) Soyuz-MFunctionCarrier rocketManufacturerOKB-1Countr...

 

 

Messale

Modena, Archivio capitolare, Messale del XII secolo. Il Messale, nella Chiesa cattolica, è un libro liturgico contenente tutte le informazioni (testi, orazioni, canti, gli stessi gesti e le rubriche) necessarie al celebrante per la celebrazione della Messa o Eucaristia secondo l'anno liturgico[1]. Indice 1 Origine 2 I diversi messali 3 Note 4 Voci correlate 5 Altri progetti 6 Collegamenti esterni Origine Il messale, detto Missale plenum, fece la sua comparsa nella Chiesa latina attor...

SMP Negeri 11 Semarang

SMP Negeri 11 SemarangInformasiDidirikan1975JenisNegeriNomor Pokok Sekolah Nasional20328839Kepala SekolahDra ERNA K. RAHAYU ,M.M, MmNIP. 19600517 198403 2 009Rentang kelasVII sampai IXKurikulum2013AlamatLokasiJl. Karangrejo Kecamatan Gajahmungkur, Semarang, Jawa Tengah, IndonesiaTel./Faks.(024) 8311762 / (024) 8508900Situs webwww.smpn11-smg.sch.idMoto SMP Negeri (SMPN) 11 Semarang, merupakan salah satu Sekolah Menengah Pertama Negeri yang ada di Jalan Karangrejo Kecamatan Gajahmungk...

 

 

Francis Patrick Dwyer

Australian chemist (1910–1962) Frank DwyerBorn(1910-12-03)3 December 1910Raymond Terrace, New South WalesDied22 June 1962(1962-06-22) (aged 51)CanberraAlma materUniversity of SydneyOccupationProfessor of ChemistryEmployer(s)Sydney Technical College (until 1946), University of Sydney (1946-1957), Pennsylvania State University (1956-1962), John Curtin School of Medical Research (1959-1962)Scientific careerDoctoral students Brice Bosnich Alan Sargeson[1] Francis Patrick John ...

 

 

Transcription (linguistics)

Systematic representation of language in written form This article is about transcription in linguistics. For other uses, see Transcription. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Transcription linguistics – news · newspapers · books · scholar · JSTOR (September 2021) (Learn how and when to rem...

Gion

Geisha district in Kyoto This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Gion – news · newspapers · books · scholar · JSTOR (April 2021) (Learn how and when to remove this message) 35°00′13″N 135°46′30″E / 35.003496°N 135.775051°E / 35.003496; 135.775051 Hanamikoji street ...

 

 

Ciphertext

Encrypted information This article is about encrypted information. For an overview of cryptographic technology in general, see Cryptography. The Zimmermann Telegram (as it was sent from Washington to Mexico) encrypted as ciphertext. KGB ciphertext found in a hollow nickel in Brooklyn in 1953 In cryptography, ciphertext or cyphertext is the result of encryption performed on plaintext using an algorithm, called a cipher.[1] Ciphertext is also known as encrypted or encoded information be...

 

 

ريجنالد ونجت

ريجنالد ونجت (بالإنجليزية: Francis Reginald Wingate)‏  معلومات شخصية الميلاد 25 يونيو 1861(1861-06-25) الوفاة 29 يناير 1953 (91 سنة)دنبار  مواطنة المملكة المتحدة المملكة المتحدة لبريطانيا العظمى وأيرلندا (–12 أبريل 1927)  الحياة العملية المدرسة الأم الأكاديمية العسكرية الملكية  المهنة دب...

Pinball

Arcade entertainment machine For other uses, see Pinball (disambiguation). The article's lead section may need to be rewritten. Please help improve the lead and read the lead layout guide. (May 2023) (Learn how and when to remove this message) Terminator 2: Judgment Day, 1991 pinball machine designed by Steve Ritchie A self-made pinball game in Niger Pinball (originally called pintable in the UK[1]) games are a family of games in which a ball is propelled into a specially designed tab...

 

 

Торбей

Торбей на карте Англии То́рбей[1] (англ. Torbay) — унитарная единица на юго-востоке церемониального графства Девон. Главный и крупнейший город — Торки (население — 64 тыс. чел.). Регион Торбей является популярным местом отдыха, его называют Английской Ривьеро...

 

 

Kirman (Sasanian province)

Province of the Sasanian Empire KirmanKirmānProvince of the Sasanian Empire224 – 650Map of KirmanCapitalKármana(224–480s)Shiragan(480s–650)Historical eraLate Antiquity• Established 224• Muslim conquest 650 Preceded by Succeeded by Parthian Empire Rashidun Caliphate Today part ofIran Kirman (Middle Persian: Kirmān) was a Sasanian province in Late Antiquity, which almost corresponded to the present-day province of Kerman. The province bordered Pars in the west, Abarshahr ...

Intersection (geometry)

Shape formed from points common to other shapes For broader coverage of this topic, see Intersection (mathematics). The red dot represents the point at which the two lines intersect. In geometry, an intersection is a point, line, or curve common to two or more objects (such as lines, curves, planes, and surfaces). The simplest case in Euclidean geometry is the line–line intersection between two distinct lines, which either is one point (sometimes called a vertex) or does not exist (if the l...

 

 

Connor Mackey

American ice hockey player Ice hockey player Connor Mackey Mackey with Team USA in 2023Born (1996-09-12) September 12, 1996 (age 27)Tower Lakes, Illinois, U.S.Height 6 ft 2 in (188 cm)Weight 200 lb (91 kg; 14 st 4 lb)Position DefenseShoots LeftNHL teamFormer teams New York RangersCalgary FlamesArizona CoyotesNational team  United StatesNHL draft UndraftedPlaying career 2021–present Connor Mackey (born September 12, 1996) is an American profes...