Mir-451 microRNA

mir-451
miR-451 microRNA secondary structure and sequence conservation
Identifiers
Symbolmir-451
RfamRF00722
miRBase familyMIPF0000148
OMIM612071
Other data
RNA typemicroRNA
Domain(s)Eukaryota; Vertebrata
PDB structuresPDBe

In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.[1]

Applications

A proof-of-concept experiment has shown that miR-451, as well as mir-126 and mir-150, could be using in forensic science to distinguish between blood and saliva samples.[2] This is made possible by different miRNA profiles of miRNAs in the different tissue types.[2]

References

  1. ^ van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance". The International Journal of Biochemistry & Cell Biology. 42 (8): 1282–1290. doi:10.1016/j.biocel.2010.01.014. PMID 20083225.
  2. ^ a b Courts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification". Journal of Forensic Sciences. 56 (6): 1464–1470. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476. S2CID 41948164.

Further reading


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