Luckovich began his career with The Greenville News (South Carolina) in 1984 and moved to the New Orleans Times-Picayune later that year. In 1989 he began his career with the Atlanta Journal-Constitution, which continues to today. In 2000, Luckovich started his comic strip "SuperZeros" about a pair of dim-witted superheroes. It was distributed by Tribune Media Service and lasted a year.
In a September 2001 interview, Luckovich commented on his style of cartooning and how it changed after the 9/11 terrorist attacks:
Normally with my cartoons I try to use humor to get across my point. After Sept. 11th, you just couldn't use humor. The tragedy was so enormous, you couldn't be funny. It's almost like you have to come up with cartoons using a different part of your brain. I was just trying to come up with images that expressed the emotions that I was feeling and tried to focus in on different aspects of the tragedy that I thought were important.
In the same interview Luckovich cited Jeff MacNelly as his "biggest editorial cartoonist role model" and Mort Drucker as his "first hero".
Luckovich attracted a great deal of backlash when the newspaper cartoonist drew a cartoon depicting Michael Jackson's death one day after his death. The comic strip illustrated the leaders Heaven and Hell flipping a coin to see what would be the late King of Pop's final destination would be after his death. Many people, including Jackson's family, friends, and fans deemed the cartoon offensive.[5]