Metfendrazine

Metfendrazine
Clinical data
Other namesMethphendrazine; HM-11; MO-482; N-Aminomethamphetamine; Methamphetamine hydrazide; N-Amino-N-methylamphetamine
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 1-methyl-1-(1-methyl-2-phenyl-ethyl)hydrazine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H16N2
Molar mass164.252 g·mol−1

Metfendrazine (developmental code names HM-11, MO-482), also known as methphendrazine, is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine family.[1][2] It was investigated as an antidepressant, but was never marketed.

Chemistry

Metfendrazine, also known as methamphetamine hydrazide, is a phenethylamine, amphetamine, and hydrazine derivative.

It is an analogue and derivative of phenelzine (phenethylamine hydrazide) and pheniprazine (amphetamine hydrazide), as well as of phenethylamine, amphetamine, and methamphetamine.

References

  1. ^ Miquel J, Mijan CD (1962). "Metfendrazine, a new inhibitor of monoamine oxidase". Archivos del Instituto de Farmacología Experimental. 14. Madrid: 47–59.
  2. ^ Kothari NJ, Saunders JC, Kline NS, Griffen JA (October 1960). "A comparison of perphenazine, proketazine, nialamide and MO-482 in chronic schizophrenics". The American Journal of Psychiatry. 117 (4): 358–360. doi:10.1176/ajp.117.4.358. PMID 13753478.