McN-481

McN-481[1]
Names
Other names
McNeil 481
NSC-42268
13M2B[2]
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C12H18N2O3/c1-5-12(8(4)6-7(2)3)9(15)13-11(17)14-10(12)16/h6,8H,5H2,1-4H3,(H2,13,14,15,16,17)
    Key: VELIJARCYHAWJO-UHFFFAOYSA-N
  • CCC1(C(=O)NC(=O)NC1=O)C(C)C=C(C)C
Properties
C12H18N2O3
Molar mass 238.287 g·mol−1
Hazards
Lethal dose or concentration (LD, LC):
3.5 mg/kg (mice, intraperitoneal)[3]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

McN-481 is a convulsant barbiturate. It is an unsaturated analog of diberal (DMBB).[3][4]

See also

References

  1. ^ Brown, DA; Quilliam, JP (October 1964). "The effects of some centrally acting drugs on ganglionic transmission in the cat". British Journal of Pharmacology and Chemotherapy. 23 (2): 241–56. doi:10.1111/j.1476-5381.1964.tb01583.x. PMC 1704089. PMID 19108183.
  2. ^ Jones, G. P.; Horn, E. (October 1986). "Conformations of barbiturates related to pentobarbitone. IV. Crystal structure of 5-ethyl,5-(1?,3?-dimethylbut-2?-enyl) barbituric acid". Journal of Crystallographic and Spectroscopic Research. 16 (5): 629–637. Bibcode:1986JCCry..16..629J. doi:10.1007/BF01181245.
  3. ^ a b Cain, C. K.; Kleis, John (February 1959). "5-Ethyl-5-(1,3-Dimethyi-2-Butenyl)Barbituric Acid, A Potent Central Nervous System Stimulant". Journal of Medicinal and Pharmaceutical Chemistry. 1 (1): 31–36. doi:10.1021/jm50002a003. PMID 13655027.
  4. ^ "Barbituric acid product". 26 March 1957.


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