Lycopene

Lycopene
Names
IUPAC name
ψ,ψ-Carotene
Systematic IUPAC name
(6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-Octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.007.227 Edit this at Wikidata
EC Number
  • 207-949-1
E number E160d (colours)
UNII
  • InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+ checkY
    Key: OAIJSZIZWZSQBC-GYZMGTAESA-N checkY
  • InChI=1/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+
    Key: OAIJSZIZWZSQBC-GYZMGTAEBZ
  • C(\C=C\C=C(\CC/C=C(\C)C)C)(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=C(\C)CC\C=C(/C)C)C)C)C)C
Properties
C40H56
Molar mass 536.888 g·mol−1
Appearance deep red solid
Density 0.889 g/cm3
Melting point 177 °C (351 °F; 450 K)[2]
Boiling point 660.9 °C (1,221.6 °F; 934.0 K)
at 760 mmHg[1]
insoluble
Solubility soluble in CS2, CHCl3, THF, ether, C6H14, vegetable oil
insoluble in CH3OH, C2H5OH[1]
Solubility in hexane 1 g/L (14 °C)[1]
Vapor pressure 1.33·10−16 mmHg (25 °C)[1]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Combustible
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g. sodium chlorideFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
0
1
0
Flash point 350.7 °C (663.3 °F; 623.8 K)[1]
Supplementary data page
Lycopene (data page)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Lycopene is an organic compound classified as a tetraterpene and a carotene.[3] Lycopene (from the Neo-Latin Lycopersicon, the name of a former tomato genus) is a bright red carotenoid hydrocarbon found in tomatoes and other red fruits and vegetables.

Occurrence

Aside from tomatoes or tomato products like ketchup, it is found in watermelons, grapefruits, red guavas, and baked beans.[4] It has no vitamin A activity.[4]

In plants, algae, and other photosynthetic organisms, lycopene is an intermediate in the biosynthesis of many carotenoids, including beta-carotene, which is responsible for yellow, orange, or red pigmentation, photosynthesis, and photoprotection.[4]

Like all carotenoids, lycopene is a tetraterpene.[4] It is soluble in fat, but insoluble in water.[4] Eleven conjugated double bonds give lycopene its deep red color.[4]

Owing to the strong color, lycopene is used as a food coloring (registered as E160d) and is approved for use in the US,[5] Australia and New Zealand (registered as 160d),[6] and the European Union (E160d).[7]

Structure and physical properties

Lycopene is a symmetrical tetraterpene because it consists entirely of carbon and hydrogen and is derived from eight isoprene subunits.[4] Isolation procedures for lycopene were first reported in 1910, and the structure of the molecule was determined by 1931. In its natural, all-trans form, the molecule is long and somewhat flat, constrained by its system of 11 conjugated double bonds. The extended conjugation is responsible for its deep red color.[4]

Plants and photosynthetic bacteria produce all-trans lycopene.[4] When exposed to light or heat, lycopene can undergo isomerization to any of a number of cis-isomers, which have a less linear shape. Isomers distinct stabilities, with highest stability: 5-cis ≥ all-trans ≥ 9-cis ≥ 13-cis > 15-cis > 7-cis > 11-cis: lowest.[8][9] In human blood, various cis-isomers constitute more than 60% of the total lycopene concentration, but the biological effects of individual isomers have not been investigated.[10]

Lycopene is a key intermediate in the biosynthesis of many carotenoids.

Carotenoids like lycopene are found in photosynthetic pigment-protein complexes in plants, photosynthetic bacteria, fungi, and algae.[4] They are responsible for the bright orange–red colors of fruits and vegetables, perform various functions in photosynthesis, and protect photosynthetic organisms from excessive light damage. Lycopene is a key intermediate in the biosynthesis of carotenoids, such as beta-carotene, and xanthophylls.[11]

Dispersed lycopene molecules can be encapsulated into carbon nanotubes enhancing their optical properties.[12] Efficient energy transfer occurs between the encapsulated dye and nanotube—light is absorbed by the dye and without significant loss is transferred to the nanotube. Encapsulation increases chemical and thermal stability of lycopene molecules; it also allows their isolation and individual characterization.[13]

Biosynthesis

The unconditioned biosynthesis of lycopene in eukaryotic plants and in prokaryotic cyanobacteria is similar, as are the enzymes involved.[4] Synthesis begins with mevalonic acid, which is converted into dimethylallyl pyrophosphate. This is then condensed with three molecules of isopentenyl pyrophosphate (an isomer of dimethylallyl pyrophosphate), to give the 20-carbon geranylgeranyl pyrophosphate. Two molecules of this product are then condensed in a tail-to-tail configuration to give the 40-carbon phytoene, the first committed step in carotenoid biosynthesis. Through several desaturation steps, phytoene is converted into lycopene. The two terminal isoprene groups of lycopene can be cyclized to produce beta-carotene, which can then be transformed into a wide variety of xanthophylls.[4]

Staining and removal

Lycopene is the pigment in tomato sauces that turns plastic cookware orange. It is insoluble in plain water, but it can be dissolved in organic solvents and oils. Because of its non-polarity, lycopene in food preparations will stain any sufficiently porous material, including most plastics. To remove this staining, the plastics may be soaked in a solution containing a small amount of chlorine bleach.[14] The bleach oxidizes the lycopene, thus rendering it colourless.

Diet

Consumption by humans

Absorption of lycopene requires that it be combined with bile salts and fat to form micelles.[4] Intestinal absorption of lycopene is enhanced by the presence of fat and by cooking.[4] Lycopene dietary supplements (in oil) may be more efficiently absorbed than lycopene from food.[4]

Lycopene is not an essential nutrient for humans, but is commonly found in the diet mainly from dishes prepared from tomatoes.[4] The median and 99th percentile of dietary lycopene intake have been estimated to be 5.2 and 123 mg/d, respectively.[15]

Sources

Dietary sources of lycopene[4]
Source mg wet weight
Gac aril 2~6 per gram[16][17]
Raw tomato 4.6 per cup
Tomato juice 22 per cup
Tomato paste 75 per cup
Tomato ketchup 2.5 per tablespoon
Watermelon 13 per wedge
Pink grapefruit 2 per half grapefruit

Fruits and vegetables that are high in lycopene include autumn olive, gac, tomatoes, watermelon, pink grapefruit, pink guava, papaya, seabuckthorn, wolfberry (goji, a berry relative of tomato), and rosehip.[4] Ketchup is a common dietary source of lycopene.[4] Although gac (Momordica cochinchinensis Spreng) has the highest content of lycopene of any known fruit or vegetable (multiple times more than tomatoes),[18][19] tomatoes and tomato-based sauces, juices, and ketchup account for more than 85% of the dietary intake of lycopene for most people.[4] The lycopene content of tomatoes depends on variety and increases as the fruit ripens.[20]

Unlike other fruits and vegetables, where nutritional content such as vitamin C is diminished upon cooking, processing of tomatoes increases the concentration of bioavailable lycopene.[4][21] Lycopene in tomato paste is up to four times more bioavailable than in fresh tomatoes.[22] Processed tomato products such as pasteurized tomato juice, soup, sauce, and ketchup contain a higher concentration of bioavailable lycopene compared to raw tomatoes.[4][23]

Cooking and crushing tomatoes (as in the canning process) and serving in oil-rich dishes (such as spaghetti sauce or pizza) greatly increases assimilation from the digestive tract into the bloodstream. Lycopene is fat-soluble, so the oil is said to help absorption. Gac has high lycopene content derived mainly from its seed coats.[24] Cara cara navel, and other citrus fruit, such as pink grapefruit, also contain lycopene.[4][25] Some foods that do not appear red also contain lycopene, e.g., baked beans.[4] When lycopene is used as a food additive (E160d), it is usually obtained from tomatoes.[4][26]

Adverse effects

Test tube containing a dichloromethane solution of lycopene

Lycopene is non-toxic and commonly found in the diet, mainly from tomato products.[4] There are cases of intolerance or allergic reaction to dietary lycopene, which may cause diarrhea, nausea, stomach pain or cramps, gas, and loss of appetite.[27] Lycopene may increase the risk of bleeding when taken with anticoagulant drugs.[27] Because lycopene may cause low blood pressure, interactions with drugs that affect blood pressure may occur. Lycopene may affect the immune system, the nervous system, sensitivity to sunlight, or drugs used for stomach ailments.[27]

Lycopenemia is an orange discoloration of the skin that is observed with high intakes of lycopene.[15] The discoloration is expected to fade after discontinuing excessive lycopene intake.[15]

Research and potential health effects

A 2020 review of randomized controlled trials found conflicting evidence for lycopene having an effect on cardiovascular risk factors,[28] whereas a 2017 review concluded that tomato products and lycopene supplementation reduced blood lipids and blood pressure.[29]

A 2015 review found that dietary lycopene was associated with reduced risk of prostate cancer,[30] whereas a 2021 meta-analysis found that dietary lycopene did not affect prostate cancer risk.[31] Other reviews concluded that research has been insufficient to establish whether lycopene consumption affects human health.[32]

Regulatory status in Europe and the United States

In a review of literature on lycopene and its potential benefit in the diet, the European Food Safety Authority concluded there was insufficient evidence for lycopene having antioxidant effects in humans, particularly in skin, heart function, or vision protection from ultraviolet light.[33]

Although lycopene from tomatoes has been tested in humans for cardiovascular diseases and prostate cancer, no effect on any disease was found.[34] The US Food and Drug Administration, in rejecting manufacturers' requests in 2005 to allow "qualified labeling" for lycopene and the reduction of various cancer risks, provided a conclusion that remains in effect as of 2015:

no studies provided information about whether lycopene intake may reduce the risk of any of the specific forms of cancer. Based on the above, FDA concludes that there is no credible evidence supporting a relationship between lycopene consumption, either as a food ingredient, a component of food, or as a dietary supplement, and any of these cancers.[34]

In a review of research through 2024, the US National Cancer Institute concluded that the FDA has not approved the use of lycopene as effective for treating any medical condition, including various types of cancer.[35]

See also

References

  1. ^ a b c d e "Lycopene". PubChem, US National Library of Medicine. 2016. Retrieved 13 October 2016.
  2. ^ Haynes, William M., ed. (2011). CRC Handbook of Chemistry and Physics (92nd ed.). CRC Press. p. 3.94. ISBN 978-1439855119.
  3. ^ Sell, Charles S. (2006). "Terpenoids". Kirk-Othmer Encyclopedia of Chemical Technology. doi:10.1002/0471238961.2005181602120504.a01.pub2. ISBN 0471238961.
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z "Carotenoids: α-Carotene, β-Carotene, β-Cryptoxanthin, Lycopene, Lutein, and Zeaxanthin". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. October 2023. Retrieved 3 December 2024.
  5. ^ "21 CFR 73.585. Tomato lycopene extract" (PDF). US Food and Drug Administration. 26 July 2005.
  6. ^ Australia New Zealand Food Standards Code"Standard 1.2.4 – Labelling of ingredients (search "lycopene")". 8 September 2011. Retrieved 2011-10-27.
  7. ^ "Current EU approved additives and their E Numbers". UK Food Standards Agency. Retrieved 2011-10-27.
  8. ^ Chasse, Gregory A.; Mak, Melody L.; Deretey, Eugen; Farkas, Imre; Torday, Ladislaus L.; Papp, Julius G.; Sarma, Dittakavi S.R; Agarwal, Anita; Chakravarthi, Sujatha; Agarwal, Sanjiv; Rao, A.Venket (2001). "An ab initio computational study on selected lycopene isomers" (PDF). Journal of Molecular Structure: Theochem. 571 (1–3): 27–37. doi:10.1016/S0166-1280(01)00424-9.
  9. ^ Chasse, Gregory A.; Chasse, Kenneth P.; Kucsman, Arpad; Torday, Ladislaus L.; Papp, Julius G. (2001). "Conformational potential energy surfaces of a Lycopene model" (PDF). Journal of Molecular Structure: Theochem. 571 (1–3): 7–26. doi:10.1016/S0166-1280(01)00413-4.
  10. ^ Erdman Jr, J. W. (2005). "How do nutritional and hormonal status modify the bioavailability, uptake, and distribution of various isomers of lycopene?". The Journal of Nutrition. 135 (8): 2046S–7S. doi:10.1093/jn/135.8.2046s. PMID 16046737.
  11. ^ NDSU Agriculture. "What Color is Your Food?". Retrieved 10 May 2012.
  12. ^ Yanagi, Kazuhiro; Iakoubovskii, Konstantin; Kazaoui, Said; Minami, Nobutsugu; Maniwa, Yutaka; Miyata, Yasumitsu; Kataura, Hiromichi (2006). "Light-Harvesting Function of β-Carotene Inside Carbon Nanotubes" (PDF). Phys. Rev. B. 74 (15): 155420. Bibcode:2006PhRvB..74o5420Y. doi:10.1103/PhysRevB.74.155420. Archived from the original (PDF) on 2020-10-02. Retrieved 2019-02-12.
  13. ^ Saito, Yuika; Yanagi, Kazuhiro; Hayazawa, Norihiko; Ishitobi, Hidekazu; Ono, Atsushi; Kataura, Hiromichi; Kawata, Satoshi (2006). "Vibrational Analysis of Organic Molecules Encapsulated in Carbon Nanotubes by Tip-Enhanced Raman Spectroscopy". Jpn. J. Appl. Phys. 45 (12): 9286–9289. Bibcode:2006JaJAP..45.9286S. doi:10.1143/JJAP.45.9286. S2CID 122152101.
  14. ^ Barnes, Chris (11 October 2011). "How To Clean Tomato Sauce Stains From Plastic Storage Containers". The Huffington Post. Retrieved 29 May 2017.
  15. ^ a b c Trumbo PR (2005). "Are there adverse effects of lycopene exposure?". The Journal of Nutrition. 135 (8): 2060S–1S. doi:10.1093/jn/135.8.2060s. PMID 16046742. Lycopenemia, characterized by an orange discoloration of the skin, has been observed with high intakes of lycopene-containing foods. One case study reported the incidence of lycopenemia in a 61-y-old woman who had consumed ~2 L of tomato juice daily for several years (10). Although there was evidence of lycopene and fatty deposits in the liver, there was an absence of measurable hepatic dysfunction. After 3 wk of consuming a diet free of tomato juice, the orange discoloration faded.
  16. ^ Ishida, BK; Turner, C; Chapman, MH; McKeon, TA (28 January 2004). "Fatty acid and carotenoid composition of gac (Momordica cochinchinensis Spreng) fruit". Journal of Agricultural and Food Chemistry. 52 (2): 274–9. Bibcode:2004JAFC...52..274I. doi:10.1021/jf030616i. PMID 14733508.
  17. ^ "Gac (Momordica cochinchinensis) Analysis report" (PDF). Archived from the original (PDF) on 2018-04-13. Retrieved 2018-04-13.
  18. ^ Tran, X. T.; Parks, S. E.; Roach, P. D.; Golding, J. B.; Nguyen, M. H. (2015). "Effects of maturity on physicochemical properties of Gac fruit (Momordica cochinchinensis Spreng.)". Food Science & Nutrition. 4 (2): 305–314. doi:10.1002/fsn3.291. PMC 4779482. PMID 27004120.
  19. ^ Ishida BK, Turner C, Chapman MH, McKeon TA (January 2004). "Fatty acid and carotenoid composition of gac (Momordica cochinchinensis Spreng) fruit". Journal of Agricultural and Food Chemistry. 52 (2): 274–9. Bibcode:2004JAFC...52..274I. doi:10.1021/jf030616i. PMID 14733508.
  20. ^ Ilahy, R; Piro, G; Tlili, I; Riahi, A; Sihem, R; Ouerghi, I; Hdider, C; Lenucci, M. S. (2016). "Fractionate analysis of the phytochemical composition and antioxidant activities in advanced breeding lines of high-lycopene tomatoes". Food Funct. 7 (1): 574–83. doi:10.1039/c5fo00553a. PMID 26462607.
  21. ^ Perdomo F, Cabrera Fránquiz F, Cabrera J, Serra-Majem L (2012). "Influence of cooking procedure on the bioavailability of lycopene in tomatoes". Hospital Nutrition (Madrid). 27 (5): 1542–6. doi:10.3305/nh.2012.27.5.5908. PMID 23478703.
  22. ^ Kamiloglu, S.; Demirci, M.; Selen, S.; Toydemir, G.; Boyacioglu, D.; Capanoglu, E. (2014). "Home processing of tomatoes (Solanum lycopersicum): Effects onin vitrobioaccessibility of total lycopene, phenolics, flavonoids, and antioxidant capacity". Journal of the Science of Food and Agriculture. 94 (11): 2225–33. Bibcode:2014JSFA...94.2225K. doi:10.1002/jsfa.6546. PMID 24375495.
  23. ^ Yamaguchi, Masayoshi (2010). Carotenoids : Properties, Effects and Diseases. New York: Nova Science Publishers. p. 125. ISBN 9781612097138.
  24. ^ Aoki, H; Kieu, N. T.; Kuze, N; Tomisaka, K; Van Chuyen, N (2002). "Carotenoid pigments in GAC fruit (Momordica cochinchinensis SPRENG)". Bioscience, Biotechnology, and Biochemistry. 66 (11): 2479–82. doi:10.1271/bbb.66.2479. PMID 12506992. S2CID 2118248.
  25. ^ Alquezar, B; Rodrigo, M. J.; Zacarías, L (2008). "Regulation of carotenoid biosynthesis during fruit maturation in the red-fleshed orange mutant Cara Cara". Phytochemistry. 69 (10): 1997–2007. Bibcode:2008PChem..69.1997A. doi:10.1016/j.phytochem.2008.04.020. PMID 18538806.
  26. ^ Li, Lei; Liu, Zhen; Jiang, Hong; Mao, Xiangzhao (2020). "Biotechnological production of lycopene by microorganisms". Appl. Microbiol. Biotechnol. 104 (24): 10307–10324. doi:10.1007/s00253-020-10967-4. PMID 33097966. S2CID 225058089.
  27. ^ a b c "Lycopene". Mayo Clinic. 2017. Archived from the original on 23 September 2017. Retrieved 29 May 2017.
  28. ^ Tierney, Audrey; Rumble, Chloe; Billings, Lauren; George, Elena (2020). "Effect of Dietary and Supplemental Lycopene on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis". Advances in Nutrition. 11 (6): 1453–1488. doi:10.1093/advances/nmaa069. PMC 7666898. PMID 32652029.
  29. ^ Cheng, Ho Ming; Koutsidis, Georgios; Lodge, John K.; Ashor, Ammar; Siervo, Mario; Lara, José (2017). "Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis" (PDF). Atherosclerosis. 257: 100–108. doi:10.1016/j.atherosclerosis.2017.01.009. ISSN 0021-9150. PMID 28129549. S2CID 19287598.
  30. ^ Chen, Ping; Zhang, Wenhao; Wang, Xiao; et al. (2015-08-21). "Lycopene and Risk of Prostate Cancer". Medicine. 94 (33): e1260. doi:10.1097/md.0000000000001260. ISSN 0025-7974. PMC 4616444. PMID 26287411.
  31. ^ Luo, Jie; Ke, Dandan; He, Qingwei (2021). "Dietary Tomato Consumption and the Risk of Prostate Cancer: A Meta-Analysis". Frontiers in Nutrition. 8: 625185. doi:10.3389/fnut.2021.625185. ISSN 2296-861X. PMC 8129008. PMID 34017849.
  32. ^ Story, EN; Kopec, R. E; Schwartz, S. J; Harris, G. K (2010). "An Update on the Health Effects of Tomato Lycopene". Annual Review of Food Science and Technology. 1 (1): 189–210. doi:10.1146/annurev.food.102308.124120. PMC 3850026. PMID 22129335.
  33. ^ "Scientific Opinion on the substantiation of health claims related to lycopene and protection of DNA, proteins and lipids from oxidative damage (ID 1608, 1609, 1611, 1662, 1663, 1664, 1899, 1942, 2081, 2082, 2142, 2374), protection of the skin from UV-induced (including photo-oxidative) damage (ID 1259, 1607, 1665, 2143, 2262, 2373), contribution to normal cardiac function (ID 1610, 2372), and maintenance of normal vision (ID 1827) pursuant to Article 13(1) of Regulation (EC) No 1924/2006". EFSA Journal. 9 (4): 2031. 2011. doi:10.2903/j.efsa.2011.2031.
  34. ^ a b "Qualified Health Claims: Letter Regarding Tomatoes and Prostate Cancer (Lycopene Health Claim Coalition) (Docket No. 2004Q-0201) (Updated 9 July 2015)". US Food and Drug Administration. 8 November 2005. Archived from the original on 22 July 2017. Retrieved 16 December 2019.
  35. ^ "Lycopene". US National Cancer Institute. 5 April 2024. Retrieved 14 September 2024.
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