Krishna Vamsi is married to Ramya Krishnan, a South Indian actress.[8][9] Ramya Krishnan acted in two of his films; Sri Anjaneyam (in a guest role) and Chandralekha, prior to marriage.[10] Krishna Vamsi is a huge a fan of Sirivennela Sitarama Sastry; the films for which Sitarama Sastry wrote lyrics, which are directed by Krishna Vamsi, include Ninne Pelladatha, Gulabi, Sindhooram, Chandralekha, Murari, Khadgam, Chakram, Mahatma, and Paisa. Sastry adopted Krishna Vamsi, though not legally as per the Gazette, but by the traditional Hindu method.