The total length on the main road is 487.2km(307.2 miles). However, by factoring in the overlapped section (33.4km/20.8 miles) and the sea crossing(19.8km/12.3 miles)the total distance becomes 540.3km(335.7miles).[4] At the origin Hamamatsu, the route starts overlapped with Route 1 and, is a junction to route 257 and 300. The route passes though the cities of Tahara, Toba, Ise, Matsusaka, Owase, Kumano, Shingū, Tanabe, and Gobō. At the terminus Wakayama, there is a junction with national route 24 and 26.
Route 42 was originally designated in January 1945 as a section of Route 41 (the Kumano Highway), which ran to Tokyo. This ran concurrent with Route 1 (now Route 1/Route 23). On 18 May 1953 Route 41 was classified as a Class 2 highway and redesignated as Route 170, which was later redesignated as Route 42 when the route was promoted to a Class 1 highway. On 1 April 1965, the classification of Class 1 and Class 2 was discontinued, redesignating it as General National Route 42.
On 1 April 1993, the highway was changed by removing the section of Tsu-Matsusaka and adding the Hamamatsu - Matsusaka. This was part of the plan to connect the Atsumi Peninsula, though the Kii Peninsula, Shikoku, Kyushu and terminating at Okinawa.[5] This plan is called the Japan Sea National Land Axis Plan.[6]
Shimizu Widening (冷水拡幅) - Partially Under Construction[21]
Kainan
Arita - Kainan Road (有田海南道路) - Partially Under Construction[21]
Arida - Kainan
Kainan Bypass (海南バイパス)
Kainan
Intersects with
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^"一般国道の路線別、都道府県別道路現況" [Road statistics by General National Highway route and prefecture] (PDF) (in Japanese). Ministry of Land, Infrastructure, Transport and Tourism. Retrieved 19 February 2020.
^一般国道42号 (in Japanese). Kinki Regional Development Bureau, Ministry of Land, Infrastructure, Transport and Tourism. Retrieved 29 November 2010.
^一般国道42 号 (in Japanese). Kinki Regional Development Bureau, Ministry of Land, Infrastructure, Transport and Tourism. Retrieved 29 November 2010.