When designated on 18 May 1953, Route 141 originally ran from Shimizu to Ueda. The section from Shimizu to Nirasaki was redesignated as Route 52 on 1 April 1963, shortening Route 141 to its current route.
^"一般国道の路線別、都道府県別道路現況" [Road statistics by General National Highway route and prefecture] (PDF) (in Japanese). Ministry of Land, Infrastructure, Transport and Tourism. Retrieved 19 February 2020.