Homoquinolinic acid

Homoquinolinic acid
Clinical data
Other namesHomoquinolinate
ATC code
  • None
Identifiers
  • 3-(Carboxymethyl)-2-pyridinecarboxylic acid
CAS Number
PubChem CID
ChemSpider
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.164.902 Edit this at Wikidata
Chemical and physical data
FormulaC8H7NO4
Molar mass181.147 g·mol−1
3D model (JSmol)
  • c1cc(c(nc1)C(=O)O)CC(=O)O
  • InChI=1S/C8H7NO4/c10-6(11)4-5-2-1-3-9-7(5)8(12)13/h1-3H,4H2,(H,10,11)(H,12,13)
  • Key:HQPMJFFEXJELOQ-UHFFFAOYSA-N

Homoquinolinic acid (HQA) is a potent excitotoxin[1] that is a conformationally restricted analogue of N-methyl-D-aspartate (NMDA) and a partial agonist of the main/glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing receptors.[2][3][4] It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor.[5] HQA has also been found to label a novel yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site.[6]

See also

References

  1. ^ Stone TW (1989). Quinolinic acid and the kynurenines. CRC Press. ISBN 978-0-8493-6592-8.
  2. ^ Stolerman IP (31 July 2010). Encyclopedia of Psychopharmacology. Springer Science & Business Media. pp. 511–. ISBN 978-3-540-68698-9.
  3. ^ de Carvalho LP, Bochet P, Rossier J (April 1996). "The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits". Neurochemistry International. 28 (4): 445–52. doi:10.1016/0197-0186(95)00091-7. PMID 8740453. S2CID 19395334.
  4. ^ Lemke TL, Williams DA (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 404–. ISBN 978-1-60913-345-0.
  5. ^ C.S.A. Neurosciences Abstracts. Cambridge Scientific Abstracts. 1984.
  6. ^ Egebjerg J, Schousboe A, Krogsgaard-Larsen P (4 October 2001). Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press. pp. 73–. ISBN 978-0-203-29938-8.
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