Margaret Dusa Waddington was born in London, England, on 18 October 1945 to Edinburgh architect Margaret Justin Blanco White, second wife of biologistConrad Hal Waddington, her father.[6] Her sister is the anthropologist Caroline Humphrey, and she has an elder half-brother C. Jake Waddington by her father's first marriage. Her mother was the daughter of Amber Reeves, the noted feminist, author and lover of H. G. Wells. McDuff grew up in Scotland where her father was Professor of Genetics at the University of Edinburgh. McDuff was educated at St George's School for Girls in Edinburgh and, although the standard was lower than at the corresponding boys' school, The Edinburgh Academy, McDuff had an exceptionally good mathematics teacher.[7] She writes:
I always wanted to be a mathematician (apart from a time when I was eleven when I wanted to be a farmer's wife), and assumed that I would have a career, but I had no idea how to go about it: I didn't realize that the choices which one made about education were important and I had no idea that I might experience real difficulties and conflicts in reconciling the demands of a career with life as a woman.[8]
After completing her doctorate in 1971 McDuff was appointed to a two-year Science Research Council Postdoctoral Fellowship at Cambridge. Following her husband, the literary translator David McDuff, she left for a six-month visit to Moscow. Her husband was studying the Russian Symbolist poet Innokenty Annensky. Though McDuff had no specific plans[9] it turned out to be a profitable visit for her mathematically. There, she met Israel Gelfand in Moscow who gave her a deeper appreciation of mathematics.[7][8] McDuff later wrote:
[My collaboration with him]... was not planned: it happened that his was the only name which came to mind when I had to fill out a form in the Inotdel office. The first thing that Gel'fand told me was that he was much more interested in the fact that my husband was studying the Russian Symbolist poet Innokenty Annensky than that I had found infinitely many type II-sub-one factors, but then he proceeded to open my eyes to the world of mathematics. It was a wonderful education, in which reading Pushkin, Mozart and Salieri played as important a role as learning about Lie groups or reading Cartan and Eilenberg. Gel'fand amazed me by talking of mathematics as though it were poetry. He once said about a long paper bristling with formulas that it contained the vague beginnings of an idea which he could only hint at and which he had never managed to bring out more clearly. I had always thought of mathematics as being much more straightforward: a formula is a formula, and an algebra is an algebra, but Gel'fand found hedgehogs lurking in the rows of his spectral sequences!
On returning to Cambridge McDuff started attending Frank Adams's topology lectures and was soon invited to teach at the University of York. In 1975 she separated from her husband, and was divorced in 1978.[6][10] At the University of York, she "essentially wrote a second PhD"[9] while working with Graeme Segal. At this time a position at Massachusetts Institute of Technology (MIT) opened up for her, reserved for visiting female mathematicians. Her career as a mathematician developed further while at MIT, and soon she was accepted to the Institute for Advanced Study where she worked with Segal on the Atiyah–Segal completion theorem. She then returned to England, where she took up a lectureship at the University of Warwick.[11]
For the past 30 years McDuff has been a contributor to the development of the field of symplectic geometry and topology. She gave the first example of symplectic forms on a closed manifold that are cohomologous but not diffeomorphic and also classified the rational and ruled symplectic four-manifolds, completed with François Lalonde.[13] More recently, partly in collaboration with Susan Tolman,[14] she has studied applications of methods of symplectic topology to the theory of Hamiltonian torus actions. She has also worked on embedding capacities of 4-dimensional symplectic ellipsoids with Felix Schlenk,[15] which gives rise to some very interesting number-theoretical questions. It also indicates a connection between the combinatorics of J-holomorphic curves in the blow up of the projective plane and the numbers that appear as indices in embedded contact homology.[10][12] With Katrin Wehrheim, she has challenged the foundational rigor of a classic proof in symplectic geometry.[16]
With Dietmar Salamon, she co-authored two textbooks Introduction to Symplectic Topology[17] and J-Holomorphic Curves and Symplectic Topology.[18][19]