Don't Give Up on Us grossed roughly ₱129 million in the Philippines. The official websites listed several international screenings but no international box-office receipts were made available by Star Cinema. It is the third Highest-Grossing Philippine-produced movie in 2006 after Sukob and Kasal, Kasali, Kasalo.
The Cinema Evaluation Board (CEB) gave Don't Give Up on Us a B rating,[2] which made it eligible for a 65% tax rebate on its earnings in the Philippines.
In a most unexpected place, love finds its way...But will it survive the journey?
Abby (Judy Ann Santos) thinks she has everything under control until her best friend Sabina walks out of her own bridal shower weeks before her marriage to Abby's younger brother Samuel. With a cassette tape left behind by Sabina as her only lead, Abby vows to find her best friend and bring her back in time for the wedding.
Abby's search takes her to Baguio. There she meets Vince (Piolo Pascual) and his younger brother Marco, a folk singer in a local pub whose voice she heard in Sabina's tape. Vince claims that he recorded the song for his friend Rabbit who was supposed to give it to his girlfriend (Sabina). Abby persuades Vince to take her to Rabbit in the hope to find Sabina. Marco thinks of an idea to get Vince and Abby together.
As Abby and Vince travel together through the mountain provinces, love tries to find its way through their hearts. But will it survive the journey?
