Nouwen played with the SV Deurne boys' team for 11 years, before joining PSV aged 17.[2]
PSV
Since 2016, Nouwen played professionally for PSV at the Eredivisie, where she recorded 69 appearances and 15 goals for the team.[3] In 2017 and 2018, she and her team were runners-up of the KNVB Women's Cup, the cup competition for women's football in the Netherlands.
Chelsea
On 12 May 2021, Nouwen agreed pre-contract terms on a three-year deal with Chelsea which commits her to the club until the summer of 2024.[4] She joined them ahead of the 2021/22 campaign.
On 10 October 2021, Nouwen made her first league start for Chelsea in a 2–0 victory against Leicester City, a game in which she would play 90 minutes.[5]
On 26 February 2022, Nouwen scored her first goal for Chelsea in a FA Cup fifth round tie against Leicester City, a game in which Chelsea would go onto win 7–0.[6]
A month later on 27 March 2022, Nouwen scored her first league goal for Chelsea. Once again Leicester City were the opponents, in a game that saw Chelsea win 9–0 away from home.[7]
On 8 May 2022, Nouwen won her first league title as Chelsea lifted the FA WSL trophy on the final day with a 4–2 victory against Manchester United.
On 15 May 2022, Nouwen lifted her second trophy with Chelsea as they defeated Manchester City for the FA Cup, Nouwen played 69 minutes.[8]
On 21 January 2023, it was announced that Nouwen had joined Italian side Milan on loan for the remainder of the 2022–23 season,[11] while at the same time it was announced she had signed a new deal to remain at Chelsea until 2025.[12] Nouwen played all 90 minutes in each of her final 10 matches for Milan, and helped the club finish third in the Serie A.[3]
On 4 March 2019, Nouwen made her debut for the Netherlands senior national team when she started and played 63 minutes in the 1–0 defeat for Poland.[13] Two days later, on 6 March, she recorded her second international cap when she replaced Siri Worm in the 66th minute of the match against China PR.[14]
On 23 October 2020, Nouwen scored her first goal for the Netherlands senior national team in a 7–0 victory over Estonia which saw the side qualify for the Women's Euros in 2022. Her second came on 28 June 2022 in a 3–0 victory over Belarus in a World Cup qualifying game.[15]
Nouwen was named to the Netherlands squad for the 2023 World Cup.[16] She made two appearances during the tournament.[3]