Ambuphylline

Ambuphylline
Names
IUPAC name
1,3-dimethyl-7H-purine-2,6-dione : 2-amino-2-methylpropan-1-ol
Other names
Theophylline aminoisobutanol, bufylline
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.024.616 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C7H8N4O2.C4H11NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-4(2,5)3-6/h3H,1-2H3,(H,8,9);6H,3,5H2,1-2H3 checkY
    Key: SEIRRUDMPNNSCY-UHFFFAOYSA-N checkY
  • InChI=1/C7H8N4O2.C4H11NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-4(2,5)3-6/h3H,1-2H3,(H,8,9);6H,3,5H2,1-2H3
    Key: SEIRRUDMPNNSCY-UHFFFAOYAX
  • O=C2N(c1nc[nH]c1C(=O)N2C)C.OCC(N)(C)C
Properties
C11H19N5O3
Molar mass 269.30 g/mol
Appearance Crystalline, slightly yellowish white powder
Melting point 254 to 256 °C (489 to 493 °F; 527 to 529 K)
Freely soluble.
Pharmacology
R03DA10 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ambuphylline (or bufylline) is a combination of theophylline and aminoisobutanol used as a bronchodilator.[1] It also acts and may be used as a diuretic.[2]

References

  1. ^ Smith, J. R.; Jensen, J. (1946). "The effect of theophylline aminoisobutanol in the failing experimental heart". The Journal of Laboratory and Clinical Medicine. 31: 455–457. PMID 21022557.
  2. ^ Dictionary querymondofacto.com Archived 4 March 2016 at the Wayback Machine


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