Al-Hirah was a significant city in pre-Islamic Arab history. Al-Hirah (4th-7th centuries) served as the capital of the Lakhmids, an Arab vassal kingdom of the Sasanian Empire, whom it helped in containing the nomadic Arabs to the south. The Lakhmid rulers of al-Hirah were recognized by Shapur II (309-379), the tenth Sasanian emperor.
A particular Mār 'Abdīšo' was born in Maysan and moved to Ḥīrā after studying elsewhere under Mār 'Abdā. There he gained widespread respect as he built a monastery and lived a pious life. The Sasanian emperor Bahram V won the throne with support of al-Mundhir I ibn al-Nu'man, king of Ḥīrā, in 420. He was amazed and showed great respect as he encountered the saint near the village of Bēṯ 'Arbī on his way back from the imperial capital Seleucia-Ctesiphon.[3]
From c. 527, al-Hirah was opposed by the Ghassanids, a Byzantine-sponsored Arab state in Syria and Palestine. The two powers engaged in a long conflict of their own that functioned as a proxy war for the Byzantine and Sasanian Empires.