The 2025 St. Louis Cardinals season will be the 144th season for the St. Louis Cardinals, a Major League Baseball franchise in St. Louis, Missouri. It will be the 134th season for the Cardinals in the National League and their 20th at Busch Stadium III.
The Cardinals released their 2025 schedule on July 18, 2024. For one of the few times in the past dozen years, the Cardinals will open the regular season at home for 2025, hosting the Minnesota Twins on Opening Day, March 27, at Busch Stadium, in its 20th season. They visit the oldest MLB-regular season stadium, Boston's Fenway Park (1912) on April 4-6, before their first National League series on April 7-9 at Pittsburgh. The season ends with a September 26-28 weekend at the second-oldest MLB-regular season stadium, Chicago's Wrigley Field (1914).[1]
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