2020 dengue outbreak in Singapore

2020 dengue outbreak in Singapore
DiseaseDengue fever
Virus strainDengue virus
LocationSingapore
Date2020
Confirmed cases35,315[1][2][3][4]
Severe cases54[1][2][3][4]
Deaths
32[1][2][3][4]
Fatality rate0.09%
Government website
NEA Dengue Cases

In the 2020 dengue outbreak in Singapore, a record-breaking number of dengue fever cases was reported in Singapore. This was part of the wider 2019–2020 dengue fever epidemic which also affected several neighbouring countries in Southeast Asia.[5]

A locally uncommon strain of the dengue virus — one that the local populace would be more susceptible to – had begun to reemerge toward the end of 2019.[6] This contributed to a four-year high in the number of people infected in the first six weeks of 2020,[7] establishing a high baseline for disease incidence even before the onset of the peak dengue season in the middle of the year.[8] There was a steep climb in the rate of infection beginning in May,[9] and by early July the total number of cases for the year was projected to surpass the previous high of 22,170 recorded in the 2013 outbreak.[10][11] The weekly disease incidence would reach a historic peak of 1,792 new cases during the week of 19–25 July.[9][12] This surge of infections drove the cumulative number of cases to 22,403 on 5 August 2020, breaking the 2013 record.[12] On 14 October, the number of deaths due to dengue reached 28, surpassing the previous record from the 2005 outbreak.[13]

The year ended with a total of 35,315 dengue fever cases, including 54 instances of dengue haemorrhagic fever, a more severe form of the disease. 32 deaths were attributed to the disease.[1][2][3][4]

Timeline

Weekly incidence of dengue fever in Singapore in 2020
Chart based on information from Weekly Infectious Diseases Bulletins issued by Ministry of Health, Singapore.[14] Data available under the terms of the Singapore Open Data Licence version 1.0.

January

  • 15 January: The National Environment Agency (NEA) warned about the reemergence of the DENV-3 strain of the dengue virus, which had not been common in Singapore in the past three decades, meaning that the local population would be more susceptible to it.[6]

February

  • 8 February: A four-year high in the number of people infected in the first six weeks of the year is reported, at 2,130 cases.[7]

May

June

  • 9 June: Infection rates doubled in the span of five weeks, from 390 new cases a week to 872. The cumulative number of cases in the year crosses the milestone of 10,000 cases.[16]
  • 12 June: 895 infections are recorded in the first five and a half days of the epidemiological week, breaking the record for number of cases in a week.[17]

July

  • 23 July: Outgoing Minister for Transport Khaw Boon Wan was hospitalised for dengue fever, just days ahead of his retirement following the 2020 general election. Due to a high temperature, he had been admitted to an isolation ward as a precaution, but was later tested negative for COVID-19.[18]
  • 25 July: The peak weekly disease incidence for the year occurs in the week of 19–25 July, which had a historic 1,792 infections, more than doubling the previous record of 891 cases in 2014.[9][12]

August

October

Epidemiology

Distribution of dengue serotypes in Singapore in 2020.[4] DENV-3 overtook DENV-2 to become the dominant strain from January to April 2020.

Resurgence of less common DENV-3 strain

There are four strains of dengue virus, DENV-1 to DENV-4. Infection with one serotype confers immunity against it, but not the others.[19]

Since 2016, DENV-2 had been the dominant strain in Singapore, causing the majority of infections. There had not been an outbreak of the less common DENV-3 in Singapore for nearly three decades, so the local population had lower immunity against it and was more susceptible to infection when DENV-3 returned as the dominant strain from January to April 2020.[6][11][20] This contributed to an unusually high number of infections even before the start of the mid-year peak dengue season, which in turn increased the momentum of dengue transmission.[8]

Concurrent COVID-19 pandemic

See also: COVID-19 pandemic in Singapore

Challenges faced by healthcare system

Response against the dengue outbreak was complicated by the concurrent COVID-19 pandemic (and vice versa), with the simultaneous outbreaks putting strain on the local healthcare system.[21] Before the development and widespread availability of accurate COVID-19 tests, doctors faced challenges in rendering the correct diagnosis,[22][23] as the two diseases share some of the same early symptoms,[21][22][23] and have clinical and laboratory characteristics in common.[24]

In February, during the early stages of the coronavirus pandemic, two patients in Singapore initially recorded false-positive test results for dengue and were thus misdiagnosed before later being found to actually have COVID-19; this included one patient who was originally reported as the first to have been infected with both diseases.[24][25][26] The discovery of such false-positive cases uncovered the risk of healthcare-associated infections, since mistaking COVID-19 for dengue could lead to the adoption of a lower level of infection control than would actually be required.[27] Consequently, additional care had to be taken during the hospital triage process, with full precautions taken when screening patients, until COVID-19 could be eliminated as a possibility.[23]

Conversely, protective measures against COVID-19 can create bottlenecks in healthcare systems and lead to delays in diagnosis;[28] confirmation that a patient does not pose a COVID-19 risk requires two consecutive negative test results obtained at least 24 hours apart.[23] However, dengue fever is also potentially deadly, and failure to treat it promptly during its critical phase can negatively impact survival outcomes.[28][29] Therefore, "detailed and strict" protocols needed to be developed and implemented to distinguish between the two diseases and conduct necessary treatment while managing the risk of COVID-19 transmission.[23][29]

Impact of COVID-19 lockdown measures

The "circuit breaker" measures implemented by the Government of Singapore to contain the spread of COVID-19 contributed to an increase in dengue cases among the general population between April and June.[30][31][32]

The Aedes aegypti mosquito, the primary vector for dengue, is a daytime feeder that dwells in indoor environments.[11][20] When all schools and 95% of workplaces were closed due to the stay-at-home-order, it forced a dramatic shift in the mobility patterns of all school-aged children and a majority of working-age adults.[30] As more people remained at home during the day due to the lockdown, this increased the number of prospective hosts for mosquitoes to target, helping fuel an increase in disease spread.[11][12][20]

A study carried out by the NEA and the School of Public Health at the National University of Singapore performed difference in differences statistical analysis to determine how changes in mobility patterns during the circuit breaker period impacted dengue infection rates. After compensating for other factors such as weather (which affects mosquito breeding and activity), seasonal effects (a surge of dengue infections is usually observed in the mid-year peak season), and the higher initial number of cases at the beginning of 2020, the study found that there were 37.2% more dengue infections (with a 95% confidence interval of 19.9%–49.8%) than would have otherwise occurred without the stay-at-home-order.[30]

Working-age adults represented the bulk of the additional infections,[32] as they spent more time working from homes with natural ventilation, rather than at their workplaces, most of which are better protected against mosquitoes due to air-conditioning.[30][33] Schoolchildren were affected to a lesser extent, experiencing a 12% increase in the number of cases compared to the norm. The reopening of schools partway through the circuit breaker has been postulated as a possible reason, as well as the fact that students would usually be home before dusk, a time of peak mosquito biting activity.[32]

The COVID-19 lockdown also had an undesirable effect on mosquito breeding. The stoppage of construction work meant that construction sites were maintained only by skeleton crews and as such more prone to accumulation of stagnant water from regular rainfall, leading to more mosquito breeding sites.[34] Vector control inspections conducted at construction sites from April to June 2020 found that 18% them harboured mosquito breeding areas, triple the amount compared to the prior three months.[32] A labour shortage caused by COVID-19 infections among the migrant worker population forced some landscaping works to be deferred, leading to an increase in untrimmed vegetation that provided a hospitable environment for mosquitoes.[20][21]

Residential areas also experienced an increase in mosquito breeding throughout the stay-at-home-order, with a sharp rise in the number of mosquito breeding sites found by vector control inspectors in homes and common areas of public housing blocks during this period, amounting to five times that of the two months prior.[11][32] This was despite a sustained publicity campaign that exhorted the community to take preventive measures to eliminate potential breeding habitats, and contrary to expectations that residents, being confined to their homes, would be better able to implement the necessary steps.[32][35] Public health experts have suggested that this could be because housekeeping demands actually increased during this period, with residents having to divide their time between remote work and child care, along with the need to prepare additional meals.[32]

On the other hand, the circuit breaker period led to a decrease in dengue infections among the migrant workforce population in Singapore.[31][33] This demographic group mostly lives in densely-packed shared dormitories, and were thus disproportionately impacted by COVID-19.[33][36] To help contain the spread of COVID-19, strict quarantine protocols were implemented to confine workers to their dormitories,[33] with several being declared as "isolation areas".[37] These measures are estimated to have led to a 68.5% reduction in the risk of contracting dengue fever for these foreign workers, or about 432 fewer cases over the duration of the quarantine, highlighting the elevated risk of dengue that migrant workers routinely face when at work.[33]

Preventive measures

The NEA conducted public communications and outreach campaigns to increase awareness and encourage the community to take preventive steps to prevent the spread of dengue. In light of the outbreak, its annual National Dengue Prevention Campaign, which usually takes place during the mid-year peak dengue season, was brought forward to March, and extended to cover a two-month duration until May.[38]

NEA also took preventive vector control measures against the Aedes aegypti mosquito, working with town councils to eliminate stagnant water and prevent mosquito breeding and coordinate chemical treatment with insecticides and larvicides in dengue clusters to reduce the mosquito population. This included an "intensive" two-week exercise as the outbreak peaked in July.[39] Over the course of the year, about 1 million inspections were conducted of homes, common areas of housing estates, construction sites and other premises to root out mosquito breeding habitats, uncovering about 23,400 instances.[40] After the number of mosquito breeding sites found in home inspections quintupled during the COVID-19 circuit breaker period, the NEA further tightened enforcement with increased fines from 15 July onward.[35]

During the peak dengue season between June and October, the Ministry of Health and NEA distributed over 300,000 bottles of mosquito repellent to dengue patients to prevent them from getting bitten, thus helping to break the chain of transmission and protect others around them.[41] In August, another 46,000 bottles were given to students of 37 schools in dengue-hit areas.[42]

The NEA expanded ongoing studies of new vector control methods involving the release of male mosquitoes carrying the Wolbachia bacteria into the field to mate with wild (non-Wolbachia-carrying) females. The resulting eggs are unable to hatch, leading to a decline in the mosquito population, with a reduction of up to 90% being observed.[43][44][45]

References

  1. ^ a b c d "Dengue surveillance data, Jan - Mar 2020" (PDF). National Environment Agency.
  2. ^ a b c d "Dengue surveillance data, Apr - Jun 2020" (PDF). National Environment Agency.
  3. ^ a b c d "Dengue surveillance data, Jul - Sep 2020" (PDF). National Environment Agency.
  4. ^ a b c d e "Dengue surveillance data, Oct - Dec 2020" (PDF). National Environment Agency.
  5. ^ Huang, Eustance (9 July 2020). "Outbreak of dengue fever in Southeast Asia is 'exploding' amid the coronavirus fight". CNBC.
  6. ^ a b c Khalik, Salma (15 January 2020). "Singapore faces dengue threat from emergence of little-seen strain". The Straits Times.
  7. ^ a b Ng, Jun Sen (11 February 2020). "Dengue cases at four-year high". today.
  8. ^ a b "Dengue Cases Expected To Exceed Last Year's 16,000 Cases Unless All Stakeholders Take Immediate Concerted Action Against Dengue". National Environment Agency. 20 April 2020.
  9. ^ a b c "NEA Urges Continued Vigilance At Start Of 2021 As Aedes Aegypti Mosquito Population Remains High And Many Residents Continue To Work From Home". National Environment Agency. 25 January 2021. The number of weekly cases rose sharply in May 2020, [...] and eventually peaked in July 2020.
  10. ^ Liu, Vanessa (2 July 2020). "Worst dengue outbreak in Singapore's history expected this year with more than 14,000 cases reported so far: NEA". The Straits Times.
  11. ^ a b c d e Gan, Nectar (3 July 2020). "Singapore is on track to face its worst dengue outbreak in history". CNN.
  12. ^ a b c d e "Singapore's dengue cases reach a record 22,403, surpassing 2013 high". today. 5 August 2020.
  13. ^ a b Ng, Keng Gene (14 October 2020). "28 people have died of dengue this year, a new high that now matches the Covid-19 death toll". The Straits Times.
  14. ^ "Weekly Infectious Diseases Bulletin, 2020". Ministry of Health, Singapore. Archived from the original on 2 March 2021. Retrieved 24 June 2022.
  15. ^ Toh, Wen Li (11 May 2020). "MP Low Yen Ling down with dengue fever as Singapore enters peak season for the disease". The Straits Times.
  16. ^ Khalik, Salma (9 June 2020). "Dengue cases surge past 10,000, with 872 infections last week alone". The Straits Times.
  17. ^ Yong, Michael (13 June 2020). "Weekly number of dengue cases in Singapore surpasses 'historical high'". Channel News Asia.
  18. ^ "Transport Minister Khaw Boon Wan hospitalised for dengue, tests negative for COVID-19". Channel News Asia. 23 July 2020.
  19. ^ Dengue Guidelines for Diagnosis, Treatment, Prevention and Control (PDF). World Health Organization. 2009. pp. 14–16. ISBN 978-92-4-154787-1. Archived from the original (PDF) on 17 October 2012. Retrieved 10 June 2022.
  20. ^ a b c d Chew, Hui Min (5 August 2020). "Dengue risk still high due to low herd immunity, more people working from home". Channel News Asia.
  21. ^ a b c Tani, Mayuko (5 August 2020). "Singapore grapples with dengue fever while battling coronavirus". Nikkei Asia.
  22. ^ a b Lam, Lawrence T M; Chua, Ying Xian; Tan, David H Y (1 August 2020). "Roles and challenges of primary care physicians facing a dual outbreak of COVID-19 and dengue in Singapore". Family Practice. 37 (4): 578–579. doi:10.1093/fampra/cmaa047. ISSN 1460-2229. PMC 7239111. PMID 32374384.
  23. ^ a b c d e Wee, Liang En; Cherng, Benjamin Pei Zhi; Conceicao, Edwin Philip; Goh, Kenneth Choon-Meng; Wan, Wei Yee; Ko, Kwan Ki Karrie; Aung, May Kyawt; Sim, Xiang Ying Jean; Wijaya, Limin; Ling, Moi Lin; Venkatachalam, Indumathi (4 November 2020). "Experience of a Tertiary Hospital in Singapore with Management of a Dual Outbreak of COVID-19 and Dengue". The American Journal of Tropical Medicine and Hygiene. 103 (5): 2005–2011. doi:10.4269/ajtmh.20-0703. ISSN 0002-9637. PMC 7646785. PMID 32996452.
  24. ^ a b Yan, Gabriel; Lee, Chun Kiat; Lam, Lawrence T M; Yan, Benedict; Chua, Ying Xian; Lim, Anita Y N; Phang, Kee Fong; Kew, Guan Sen; Teng, Hazel; Ngai, Chin Hong; Lin, Li; Foo, Rui Min; Pada, Surinder; Ng, Lee Ching; Tambyah, Paul Anantharajah (2020). "Covert COVID-19 and false-positive dengue serology in Singapore". The Lancet Infectious Diseases. 20 (5). Elsevier BV: 536. doi:10.1016/s1473-3099(20)30158-4. ISSN 1473-3099. PMC 7128937. PMID 32145189.
  25. ^ Tee Zhuo; Timothy Goh (20 February 2020). "Coronavirus: S'pore confirms first patient with both Covid-19 and dengue, all warded with her quarantined at Ng Teng Fong". The Straits Times.
  26. ^ Wong, Cara (9 March 2020). "2 coronavirus patients test positive for dengue despite not having the mosquito-borne disease". The Straits Times.
  27. ^ Prasitsirikul, Wisit; Pongpirul, Krit; Pongpirul, Wannarat A.; Panitantum, Nayot; Ratnarathon, Anuttra C.; Hemachudha, Thiravat (1 January 2020). "Nurse infected with Covid-19 from a provisional dengue patient". Emerging Microbes & Infections. 9 (1): 1354–1355. doi:10.1080/22221751.2020.1775131. ISSN 2222-1751. PMC 7473270. PMID 32458742.
  28. ^ a b Nacher, Mathieu; Douine, Maylis; Gaillet, Mélanie; Flamand, Claude; Rousset, Dominique; Rousseau, Cyril; Mahdaoui, Chedli; Carroll, Stanley; Valdes, Audrey; Passard, Nathalie; Carles, Gabriel (14 August 2020). "Simultaneous dengue and COVID-19 epidemics: Difficult days ahead?". PLOS Neglected Tropical Diseases. 14 (8): e0008426. doi:10.1371/journal.pntd.0008426. ISSN 1935-2735. PMC 7428060. PMID 32797035.
  29. ^ a b Wilder-Smith, Annelies; Tissera, Hasitha; Ooi, Eng Eong; Coloma, Josefina; Scott, Thomas W.; Gubler, Duane J. (5 August 2020). "Preventing Dengue Epidemics during the COVID-19 Pandemic". The American Journal of Tropical Medicine and Hygiene. 103 (2): 570–571. doi:10.4269/ajtmh.20-0480. ISSN 0002-9637. PMC 7410414. PMID 32539912.
  30. ^ a b c d Lim, Jue Tao; Chew, Lawrence Zheng Xiong; Choo, Esther Li Wen; Dickens, Borame Sue Lee; Ong, Janet; Aik, Joel; Ng, Lee Ching; Cook, Alex R (1 February 2021). "Increased Dengue Transmissions in Singapore Attributable to SARS-CoV-2 Social Distancing Measures". The Journal of Infectious Diseases. 223 (3): 399–402. doi:10.1093/infdis/jiaa619. ISSN 0022-1899. PMC 7543616. PMID 33000172.
  31. ^ a b Kok, Charlene (14 May 2021). "Dengue: A Tale Of Two Lockdowns". Asian Scientist.
  32. ^ a b c d e f g Cook, Alex R (1 October 2020). "Uncovering the factors fueling record-high dengue cases in Singapore". Channel News Asia.
  33. ^ a b c d e Lim, Jue Tao; Dickens, Borame Lee; Ong, Janet; Aik, Joel; Lee, Vernon J; Cook, Alex R; Ng, Lee Ching (1 March 2021). "Decreased dengue transmission in migrant worker populations in Singapore attributable to SARS-CoV-2 quarantine measures". Journal of Travel Medicine. 28 (2): taaa228. doi:10.1093/jtm/taaa228. ISSN 1708-8305. PMC 7798931. PMID 33274384.
  34. ^ Liu, Vanessa (22 April 2020). "Idle construction sites during circuit breaker spark concerns they may become hot spots for dengue". The Straits Times.
  35. ^ a b Tan, Sue-Ann (22 June 2020). "Heavier penalties and higher fines for those breeding mosquitoes as dengue cases rise". The Straits Times.
  36. ^ Bhandare, Namita (21 April 2020). "Singapore's Coronavirus Success Story Hits a Snag". Foreign Policy.
  37. ^ "COVID-19: Four more foreign worker dormitories declared as isolation areas". Channel News Asia. 24 April 2020.
  38. ^ "NEA Brings Forward National Dengue Prevention Campaign And Rolls Out Additional New Tools To Combat Dengue, With Increasing Evidence Of A Sustained Switch In Dengue Virus Serotype". National Environment Agency. 22 March 2020.
  39. ^ "NEA begins 2-week 'intensive' vector control exercise as number of dengue cases set to surpass worst outbreak". Channel News Asia. 24 July 2020.
  40. ^ "Dengue risk remains as Aedes mosquito population has grown: NEA". Channel News Asia. 25 January 2021.
  41. ^ Iau, Jean (18 May 2020). "Over 300,000 bottles of mosquito repellent to be given to patients suspected to have dengue". The Straits Times.
  42. ^ "More than 46,000 bottles of mosquito repellent given to students in some schools amid dengue outbreak". Channel News Asia. 18 August 2020.
  43. ^ "Wolbachia mosquito field test 'successful', project expanded to dengue high-risk areas in Choa Chu Kang, Bukit Batok". Channel News Asia. 6 May 2020.
  44. ^ "Anti-dengue Wolbachia mosquito project shows 'promising results'; to cover all Tampines, Yishun HDB towns from July". Channel News Asia. 17 July 2020.
  45. ^ Edgar Su; Joseph Campbell (28 August 2020). "Singapore battles record dengue outbreak with more mosquitoes". Reuters.