This unit has a long and distinguished history that lives up to the Medical Branch's tradition of being faithful in adversity. It is the latest in a line of Saskatchewan army medical units dating back to 21 Field Ambulance of World War I and 10 Field Ambulance of World War II.
World War II
From 1940 to 1941, the unit trained at Camp Dundurn, in preparation for deployment to England. Once deployed, the unit provided medical services, as well as successfully evacuating thousands of Canadian and Allied units.
Post-World War II to 1990
In the early 1970s, the unit was disbanded along with all militia medical units across Canada, but was reformed as a Medical Company, as part of 16 Service Battalion, a combat service support unit, based out of Regina Garrison in Regina, Saskatchewan.
1990–present
In the early 1990s, the unit received official detachment status for its detachment operating in Saskatoon, Saskatchewan, out of Sgt. Hugh Cairns VC Armoury. In 2004, the Canadian Forces Medical Service underwent a reorganization, and 16 Medical Company became its own unit again, and was renamed 16 (Regina) Field Ambulance.