مضادات فيتامين ك

ملصق تحذيري على أنبوب من سم "الفئران البنية" موصول على سد من نهر شيلدت في ستيندورب، بلجيكا. يحتوي الأنبوب على مادة بروماديولون، وهو مضاد للتخثر من الجيل الثاني (superwarfarin). الملصق في الولايات الهولندية، جزئيًا: يحتوي على مضاد تخثر مع نشاط طويل الأمد. ترياق فيتامين ك 1.

مضادات فيتامين ك (بالإنجليزية: Vitamin K antagonist)‏ هي مجموعة من المواد التي تقلل من تخثر الدم عن طريق الحد من عمل فيتامين ك.[1] تٌستخدم مضادات فيتامين ك كأدوية مضادة للتخثر للوقاية من تجلط الدم، وفي مكافحة الآفات، وكمبيدات للقوارض.

آلية العمل

تستنفد هذه الأدوية الشكل النشط للفيتامين عن طريق تثبيط إنزيم فيتامين ك إيبوكسيدد المختزل وبالتالي إعادة تدوير إيبوكسيد فيتامين ك غير النشط إلى الشكل النشط المخفض لفيتامين ك.

يمكن لمضادات فيتامين ك أن تسبب عيوب خلقية (مسرطنة).[2]

مراجع

  1. ^ "معلومات عن مضادات فيتامين ك على موقع whocc.no". whocc.no. مؤرشف من الأصل في 2016-06-17.
  2. ^ Schaefer C، Hannemann D، Meister R، وآخرون (June 2006). "Vitamin K antagonists and pregnancy outcome. A multi-centre prospective study". Thromb. Haemost. ج. 95 ع. 6: 949–57. DOI:10.1160/TH06-02-0108. PMID:16732373. مؤرشف من الأصل في 9 أبريل 2016. اطلع عليه بتاريخ أكتوبر 2020. {{استشهاد بدورية محكمة}}: تحقق من التاريخ في: |تاريخ الوصول= (مساعدة)

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