Trombin

Trombin (bahasa Inggris: Thrombin,[1] Factor II, FII) adalah sejenis glikoprotein yang dibentuk oleh dan disimpan dalam hati. Sekresi protrombin ke dalam plasma darah terjadi karena stimulasi dari tromboplastin dan ion kalsium pada proses koagulasi.[2] Dalam proses tersebut, protrombin kemudian dikonversi menjadi trombin[3] oleh protrombinase.[4] Lebih lanjut, trombin akan mengkonversi fibrinogen menjadi fibrin.[4]

Vitamin K merupakan senyawa organik yang sangat penting pada sintesis protrombin.[4][5]

Rujukan

  1. ^ (Inggris) "Definition of Prothrombin". MedicineNet. Diakses tanggal 2010-04-28. 
  2. ^ (Inggris) "Prothrombin". The American Heritage® Medical Dictionary; Houghton Mifflin Company. Diakses tanggal 2010-04-28. 
  3. ^ (Inggris) "Prothrombin". Gale Encyclopedia of Medicine. Diakses tanggal 2010-04-28. 
  4. ^ a b c (Inggris) "Prothrombin". Encyclopædia Britannica. Diakses tanggal 2010-04-28. 
  5. ^ (Inggris) "Prothrombin". Mosby's Dental Dictionary. Diakses tanggal 2010-04-28. 

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