Filamen PH (bahasa Inggris : neurofibrillary tangle, paired helical filaments, PHF protein yang ditemukan pertama kali oleh Alois Alzheimer di dalam neuron penderita Alzheimer .[ 1]
Filamen ini terbentuk dari berbagai isomer [ 2] protein tau [ 3] protein yang berperan dalam perakitan dan pemeliharaan struktur mikrotubula - mengalami hiperfosforilasi sehingga memecahkan struktur mikrotubula . Radikal protein tau kemudian berhimpun menjadi filamen PH di dalam soma .[ 4]
Hiperfosforilasi terjadi karena terjadi kerusakan transduksi sinyal seluler yang disebabkan oleh tid ak seimbangnya aktivitas protein dari beberapa enzim fosfatase dan kinase ,[ 4] calmodulin-dependent protein kinase II , glycogen synthase kinase-3beta cyclin-dependent protein kinase 5 .[ 5] [ 6] enzim fosfoseril protein fosfatase [ 7] fosfotreonil protein fosfatase .[ 8]
Rujukan
^ alzi (2019-06-15). "Apa yang menyebabkan demensia?" . Alzheimer Indonesia (dalam bahasa Inggris). Diakses tanggal 2024-09-28 . ^ (Inggris) "Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease" . Medical Research Council, Laboratory of Molecular Biology, Cambridge, England; Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA . Diarsipkan dari asli tanggal 2019-12-15. Diakses tanggal 2010-06-27 .^ (Inggris) "Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau" . Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom; Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A . Diarsipkan dari asli tanggal 2019-04-01. Diakses tanggal 2010-06-27 .^ a b (Inggris) "The Role of Tau in Alzheimer's Disease and Related Disorders" . Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California; Medeiros R, Baglietto-Vargas D, Laferla FM . Diarsipkan dari asli tanggal 2019-12-25. Diakses tanggal 2010-06-21 .^ (Inggris) "Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention" . Department of Neurochemistry New York State Institute for Basic Research in Developmental Disabilities; Iqbal K, Grundke-Iqbal I . Diarsipkan dari asli tanggal 2016-06-11. Diakses tanggal 2010-06-21 .^ (Inggris) "Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration" . Pathophysiology Department, Tongji Medical College, Huazhong University of Science & Technology; Wang JZ, Grundke-Iqbal I, Iqbal K . Diarsipkan dari asli tanggal 2017-07-15. Diakses tanggal 2010-06-21 .^ (Inggris) "Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies" . Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities; Iqbal K, Grundke-Iqbal I . Diarsipkan dari asli tanggal 2023-07-21. Diakses tanggal 2010-06-21 .^ (Inggris) "Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach" . New York State Institute for Basic Research in Developmental Disabilities; Iqbal K, Alonso AD, Gondal JA, Gong CX, Haque N, Khatoon S, Sengupta A, Wang JZ, Grundke-Iqbal I . Diarsipkan dari asli tanggal 2019-04-10. Diakses tanggal 2010-06-21 .
