Desloratadin

Desloratadin
Nama sistematis (IUPAC)
8-kloro-6,11-dihidro-11-(4-piperdinilidena)- 5H-benzo[5,6]siklohepta[1,2-b]piridin
Data klinis
Nama dagang Clarinex, Aerius, Allex, dll[1]
AHFS/Drugs.com monograph
MedlinePlus a602002
Data lisensi US Daily Med:pranala
Kat. kehamilan B1(AU)
Status hukum Apotek saja (S2) (AU) OTC (CA) POM (UK) ℞-only (US)
Rute Oral
Data farmakokinetik
Bioavailabilitas Diserap dengan cepat
Ikatan protein 83 – 87%
Metabolisme UGT2B10, CYP2C8
Waktu paruh 27 jam,[2] 33.7 jam pada pasien yang tua[3]
Ekskresi 40% sebagai metabolit terkonjugasi dalam urin Jumlah yang sama masuk ke dalam tinja
Pengenal
Nomor CAS 100643-71-8 YaY
Kode ATC R06AX27
PubChem CID 124087
Ligan IUPHAR 7157
DrugBank DB00967
ChemSpider 110575 YaY
UNII FVF865388R YaY
KEGG D03693 YaY
ChEBI CHEBI:291342 YaY
ChEMBL CHEMBL1172 YaY
Sinonim deskarboetoksiloratadin[4]
Data kimia
Rumus C19H19ClN2 
SMILES eMolecules & PubChem

  • InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 YaY
    Key:JAUOIFJMECXRGI-UHFFFAOYSA-N YaY

Desloratadin adalah trisiklik Antihistamin H1 yang digunakan untuk mengobati alergi. Senyawa kimia ini merupakan metabolit aktif dari loratadin. Nama dagangnya adala Clarinex di Amerika Serikat dan Aerius di Eropa dan Kanada.

Referensi

  1. ^ Murdoch D, Goa KL, Keam SJ (7 April 2003). "Desloratadine: an update of its efficacy in the management of allergic disorders". Drugs. 63 (19): 2051–2077. doi:10.2165/00003495-200363190-00010. PMID 12962522. 
  2. ^ Lieberman P, Hernandez-Trujillo V, Lieberman J, Frew AJ (2008). "Antihistamines". Clinical Immunology. Elsevier. hlm. 1317–1329. doi:10.1016/b978-0-323-04404-2.10089-2. ISBN 9780323044042. 
  3. ^ "Clarinex- desloratadine tablet, film coated". DailyMed. 14 November 2022. Diakses tanggal 18 May 2024. 
  4. ^ Schering Corporation (2000). "CLARITIN brand of Loratadine - Full Prescribing Information (US FDA)" (PDF). US FDA. Diakses tanggal 17 May 2024. loratadine is metabolized to descarboethoxyloratadine predominantly by cytochrome P450 3A4 (CYP3A4) and, to a lesser extent, by cytochrome P450 2D6 (CYP2D6). 
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