帕诺米芬

帕诺米芬
臨床資料
其他名稱GYKI-13504; EGIS-5650
识别信息
  • 2-[2-[4-[(E)-3,3,3-trifluoro-1,2-diphenylprop-1-enyl]phenoxy]ethylamino]ethanol
CAS号77599-17-8
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C25H24F3NO2
摩尔质量427.47 g·mol−1
3D模型（JSmol（英语：JSmol））
  • C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C(F)(F)F)/C3=CC=C(C=C3)OCCNCCO
  • InChI=1S/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+
  • Key:MHXVDXXARZCVRK-WCWDXBQESA-N

帕诺米芬（INN：Panomifene；开发代号：GYKI 13504和EGIS 5650）是三苯乙烯基的非甾体选择性雌激素受体调节剂（SERM），与他莫昔芬相关。该药物在1990年代由Egis Pharmaceuticals和IVAX药物研究所开发为抗肿瘤药物，用于治疗乳癌，但从未上市。[1][2][3][4][5][6]它在开发终止之前达到了II期临床试验。[2]该药物于1981年被描述。[1]

参考资料

  1. ^ 1.0 1.1 J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 930–. ISBN 978-1-4757-2085-3. 
  2. ^ 2.0 2.1 Panomifene. AdisInsight. [2023-02-07]. （原始内容存档于2017-04-12）. 
  3. ^ Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 60–. ISBN 978-3-642-58616-3. 
  4. ^ Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. 6 December 2012: 292–. ISBN 978-3-642-60107-1. 
  5. ^ Pierre H. Dixneuf; Christian Bruneau. Ruthenium in Catalysis. Springer. 18 October 2014: 385–. ISBN 978-3-319-08482-4. 
  6. ^ Borvendég J, Hermann I, Csuka O. Antiestrogens, antiandrogens. Acta Physiol Hung. 1996, 84 (4): 405–6. PMID 9328614. 

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