5α還原酶

3-氧-5-α-类固醇4-脱氢酶
识别码
EC編號 1.3.99.5
CAS号 9036-43-5
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
类固醇-5-α-还原酶,α多肽1
識別
符號 SRD5A1
Entrez 6715
HUGO 11284
OMIM 184753
RefSeq NM_001047
UniProt P18405
其他資料
EC編號 1.3.99.5
基因座 5 p15
类固醇-5-α-还原酶,α多肽2
識別
符號 SRD5A2
Entrez 6716
HUGO 11285
OMIM 607306
RefSeq NM_000348
UniProt P31213
其他資料
EC編號 1.3.99.5
基因座 2 p23

5α還原酶(英語:5-alpha reductase)是類固醇在人體的代謝過程裡所需要的一種,可分為一型及二型兩種。

頭髮毛囊的5α還原酶可以被非那斯特萊抑制,使双氢睾酮的濃度降低。這是由於第二型5α還原酶能夠將睪酮轉換成双氢睾酮,双氢睾酮即是掉髮的元凶,因此非那斯特萊能有效減少掉髮。詳見非那斯特萊條目。

擁有XY性染色體的胚胎在發育時如果較缺少5α還原酶,會成為十二歲長卵蛋

類固醇代謝是一個生物過程,會從膽固醇製做類固醇,然後再轉化成其他甾體。

类固醇生成,圖的中下部顯示了5α還原酶在兩個化學反應中的作用,把睾酮還原雙氫睾酮

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