2,3-二磷酸甘油酸

2,3-二磷酸甘油酸
IUPAC名
2,3-Bisphosphoglycerate
别名 2,3-二磷酸甘油酸盐
识别
缩写 2,3-BPG; 2,3-DPG; 23BPG
CAS号 138-81-8  checkY
PubChem 61
ChemSpider 161681, 60 (Racemic)
SMILES
 
  • O=P(O)(OC(C(=O)O)COP(=O)(O)O)O
InChIKey XOHUEYCVLUUEJJ-UWTATZPHBL
ChEBI 17720
性质
化学式 C3H8O10P2
摩尔质量 266.04 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

2,3-二磷酸甘油酸（英語：2,3-Bisphosphoglyceric acid，简称为2,3-BPG或2,3-DPG）是糖酵解中间产物1,3-二磷酸甘油酸（1,3-BPG）的一个三碳异构体。2,3-二磷酸甘油酸存在于人的红细胞中，浓度约为5 mmol/L。较之于结合氧气的血红蛋白（如当红细胞接近肺部时），这种物质对去氧血红蛋白具有更大的结合亲和力（如当红细胞接近呼吸中的组织时），所以可以透過跟之結合導致氧氣的親和力降低，來使得紅血球放出氧。

发生这种现象的原因是2,3-二磷酸甘油酸（其尺寸大约9Å）的尺寸正好适合于脱氧气血红蛋白构象（11Å），但是不适合于结合氧气血红蛋白（5Å）。通过降低脱氧气血红蛋白对氧气的亲和力，2,3-二磷酸甘油酸与脱氧气血红蛋白β亚基相互作用，通过构象改变，它推动了剩余结合到血红蛋白上的氧气释放出来，因此增强了红细胞在接近最需要氧气的组织时释放氧气的能力。因而可以说2,3-二磷酸甘油酸是一种别构调节物。[1]

新陳代謝

[2]

註釋

  1. ^ Benesch, R.; Benesch, R.E. The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin.. Biochem Biophys Res Commun. 1967, 26 (2): 162–7. PMID 6030262. doi:10.1016/0006-291X(67)90228-8. 
  2. ^ Müller-Esterl, W. Biochemistry: Fundamentals Of Medicine And The Science Of Life.. Editorial Reverté. 2008: 660. 

参考文献

  • Berg, J.M., Tymockzko, J.L. and Stryer L. Biochemistry (5th ed). W.H. Freeman and Co, New York, 1995. ISBN 0-7167-4684-0.
  • -684392408 於 GPnotebook
  • Online medical dictionary
  • Nelson, David L.; Cox, Michael M.; Lehninger, Albert L. "Principles of Biochemistry (4th ed)". W.H. Freeman, 2005. ISBN 978071674339.
  • Muller-esterl,W. "Biochemistry: "Fundamentals Of Medicine And The Science Of Life (2nd ed.)". Reverté, 2008. ISBN 8429173935.
  • Rodak. "Hematology. Clinical principles and applications (2nd ed.)" Elsevier Science, Philadelphia, 2003. ISBN 950-06-1876-1.
  • González-Cinca N, Pérez de la Ossa P, Carreras J, Climent F."Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivo". Unitat de Bioquímica, Departament de Ciéncies Fisiològiques I, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain, 2004.
  • Nielsen AL, Andersen EM, Jørgensen LG, Jensen HA. "Oxygen and 2,3 biphosphoglycerate (2,3-BPG) during haemodialysis". Department of Nephrology, Hvidovre University Hospital, Denmark, 1998.
  • "Anales de la Real Academia Nacional de Medicina (cuaderno cuarto)". ISSN: 0034-0634

外部链接

Read other articles:

اتحاد إستونيا لكرة القدم

الاتحاد الإستوني لكرة القدم الاسم المختصر EJL الرياضة كرة القدم أسس عام 1921 (منذ 103 سنوات) المقر تالين  الانتسابات الفيفا : 1923 UEFA  : 1992 رمز الفيفا EST  الموقع الرسمي www.jalgpall.ee تعديل مصدري - تعديل   الشعار السابق للاتحاد تأسس الاتحاد الأستوني لكرة القدم في عام 1921م وانضم ...

 

Tarqeq (satelit)

Diagram ini menunjukkan orbit satelit iregular Saturnus. Di tengah, orbit Titan, sebuah satelit yang regular, ditandai dengan warna merah sebagai perbandingan. Tarqeq (satelit) adalah satelit alami dari planet Saturnus. Saturnus memiliki 62 satelit, dengan 53 di antaranya telah dinamai dan hanya 13 di antaranya memiliki diameter lebih besar dari 50 kilometer. Referensi http://solarsystem.nasa.gov/planets/profile.cfm?Display=Sats&Object=Saturn Diarsipkan 2014-04-16 di Wayback Machine.

 

The Bulls & the Bees

2012 EP by MelvinsThe Bulls & the BeesEP by MelvinsReleasedMarch 13, 2012Genre Sludge metal neoclassical experimental dark ambient Length23:33LabelScion A/VMelvins chronology Sugar Daddy Live(2011) The Bulls & the Bees(2012) Freak Puke(2012) The Bulls & the Bees is an EP by American rock band the Melvins, released on March 13, 2012[1] through Scion A/V for free download. It was also released as a free CD for their May 2012 tour with Unsane and released as a 10 vin...

Campagna delle isole Aleutine

Campagna delle isole Aleutineparte del teatro del Pacifico della seconda guerra mondialeTruppe americane esaminano uno Zero giapponese abbattuto presso l'Isola di AkutanData3 giugno 1942 - 15 agosto 1943 LuogoIsole Aleutine, Alaska EsitoVittoria alleata Schieramenti Stati Uniti Canada Giappone Comandanti Thomas KinkaidFrancis RockwellAlbert BrownArchibald ArnoldSimon Bolivar Buckner Jr. George PearkesHarry FosterBoshirō HosogayaKakuji KakutaYasuyo Yamasaki Effettivi144.000[1 ...

 

Kim Ji-ho (penyanyi)

Dalam nama Korean ini, nama keluarganya adalah Kim. Kim Ji-hoJiho pada saat acara penandatanganan penggemar yang diadakan di Distrik GuroLahirKim Ji-ho04 April 1997 (umur 27)Okcheon, Chungcheong Utara, Korea SelatanPekerjaanPenyanyi, penariKarier musikGenreK-popInstrumenVokalTahun aktif2015–sekarangLabel WM Entertainment (2015-2022) Jiho (Hangul: 지호) atau Kim Ji-ho (Hangul: 김지호, lahir 4 April 1997)[1] adalah mantan anggota dan salah satu vokalis utama dari grup Oh My ...

 

Pipe Dream (musical)

1955 musical Pipe DreamOriginal Broadway poster (1955)MusicRichard RodgersLyricsOscar Hammerstein IIBookOscar Hammerstein IIBasisSweet Thursday, a novel by John SteinbeckProductions1955 Broadway Pipe Dream is the seventh musical by the team of Richard Rodgers and Oscar Hammerstein II; it premiered on Broadway on November 30, 1955. The work is based on John Steinbeck's novel Sweet Thursday—Steinbeck wrote the novel, a sequel to Cannery Row, in the hope of having it adapted into a musical. Se...

Hindupur Lok Sabha constituency

Lok Sabha Constituency in Andhra Pradesh HindupuramLok Sabha constituencyConstituency detailsCountryIndiaRegionSouth IndiaStateAndhra PradeshAssembly constituenciesRaptaduMadakasiraHindupuramPenukondaPuttaparthiDharmavaramKadiriEstablished1957Total electors14,46,496ReservationNoneMember of Parliament17th Lok SabhaIncumbent Kuruva Gorantla Madhav Party  YSRCPElected year2019 Hindupuram Lok Sabha constituency is one of the twenty-five lok sabha constituencies of Andhra Pradesh in Indi...

 

Ular padi

Ular padi Hypsiscopus TaksonomiKerajaanAnimaliaFilumChordataKelasReptiliaOrdoSquamataFamiliHomalopsidaeGenusHypsiscopus Fitzinger, 1843 lbs Ular padi adalah sebutan untuk dua spesies ular air yang diklasifikasikan dalam genus Hypsiscopus. Dinamakan ular padi karena ular-ular ini sering dijumpai di perairan sawah. Ular-ular ini terdapat di Asia Tenggara. Spesies Hypsiscopus matannensis (Boulenger, 1897) Hypsiscopus plumbea (Boie, 1827) - Ular-air kelabu Referensi Hypsiscopus @ The Reptile Data...

 

Hohenzollern-Hechingen

Principality located in modern day Germany This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Hohenzollern-Hechingen – news · newspapers · books · scholar · JSTOR (July 2016) (Learn how and when to remove this message) Principality of Hohenzollern-HechingenFürstentum Hohenzollern-Hechingen (German)1576–...

UFC 5

UFC mixed martial arts event in 1995 For the video game, see EA Sports UFC 5. UFC 5: Gracie vs. Shamrock 2The poster for UFC 5: Gracie vs. Shamrock 2InformationPromotionUltimate Fighting ChampionshipDateApril 7, 1995VenueIndependence ArenaCityCharlotte, North Carolina, United StatesAttendance6,000Buyrate260,000[1]Event chronology UFC 4: Revenge of the Warriors UFC 5: Gracie vs. Shamrock 2 UFC 6: Clash of the Titans UFC 5: The Return of the Beast was a mixed martial arts event held by ...

 

Quarry Bay Park

Urban park in Quarry Bay, Hong Kong Quarry Bay Park鰂魚涌公園LocationQuarry Bay, Hong KongOpened17 June 1994; 29 years ago (1994-06-17)Operated byLeisure and Cultural Services DepartmentOpenYear roundPublic transit accessTai Koo stationQuarry Bay stationHong Kong Tramways Arbor in Phase One of Quarry Bay Park. On the left is the Taikoo Shing private residential development, and the Island Eastern Corridor is on the right. A playground inside the park Quarry Bay Par...

 

Esmee Brugts

Dutch footballer (born 2003) Esmee Brugts Brugts with Barcelona in 2024Personal informationFull name Esmee Virginia Brugts[1]Date of birth (2003-07-28) 28 July 2003 (age 20)Place of birth Heinenoord, NetherlandsPosition(s) Midfielder, forwardTeam informationCurrent team BarcelonaNumber 24Youth career2008–2016 SV Heinenoord [nl]2016–2020 FC Binnenmaas [nl]Senior career*Years Team Apps (Gls)2020–2023 PSV 54 (15)2023– Barcelona 22 (6)International c...

SMA Negeri 1 Gombong

SMA Negeri 1 GombongInformasiDidirikan16 Agustus 1963JenisNegeriAkreditasiAKepala SekolahDrs. Eko Mujiyono, M.M.Jumlah kelas10 kelas setiap tingkatJurusan atau peminatanIPA, IPS dan bahasaRentang kelasX IPA, X IPS, X Bahasa, XI IPA, XI IPS, XII IPA, XII IPSKurikulumKurikulum 2013 Kurikulum MerdekaJumlah siswa1067StatusNegeri‎NEM terendah31,35 (2011)NEM tertinggi40,45 (2011)AlamatLokasiJalan Sempor Lama No. 64, Gombong, Gombong, Jawa Tengah, IndonesiaTel./Faks.0287 471170Koord...

 

Charles & Diana: A Royal Love Story

American TV series or program Charles & Diana: A Royal Love StoryGenreDramaromanceBased onWedding of Prince Charles and Lady Diana SpencerWritten byJohn McGreevyDirected byJames GoldstoneStarringDavid RobbCaroline BlissMusic byJohn AddisonCountry of originUnited StatesOriginal languageEnglishProductionExecutive producerEdward S. FeldmanProducerClyde PhillipsCinematographyTed MooreEditorsEdward A. BieryJohn TroppelerRunning time95 minutesProduction companiesEdward S. Feldman CompanySt. Lo...

 

Baldur's Gate: Enhanced Edition

2012 video game 2012 video gameBaldur's Gate: Enhanced EditionDeveloper(s)Overhaul GamesPublisher(s)AtariBeamdogSkybound Games (consoles)Director(s)Trent OsterComposer(s)Sam Hulick[3]SeriesBaldur's GatePlatform(s)Microsoft Windows, iOS, OS X, Android, Linux, Nintendo Switch, PlayStation 4, Xbox OneReleaseMicrosoft WindowsNovember 28, 2012[1][2]iOSDecember 7, 2012 OS XFebruary 22, 2013AndroidApril 17, 2014 LinuxNovember 27, 2014Nintendo Switch, PlayStation 4, Xbox OneOc...

Galantamine

Neurological medication GalantamineClinical dataTrade namesRazadyne, Reminyl, othersAHFS/Drugs.comMonographMedlinePlusa699058License data US DailyMed: Razadyne Pregnancycategory AU: B1[1] Routes ofadministrationBy mouthATC codeN06DA04 (WHO) Legal statusLegal status BR: Class C1 (Other controlled substances)[2] EU: Rx-only[3] In general: ℞ (Prescription only) Pharmacokinetic dataBioavailability80–100%Protein binding18%Met...

 

Adozione nell'antica Roma

L'Augusto di Prima Porta, statua in marmo attualmente conservata ai Musei Vaticani. Augusto, primo imperatore romano, fu adottato dal prozio materno Gaio Giulio Cesare. L'adozione, in particolar modo di giovani di sesso maschile, fu nella storia romana una pratica particolarmente diffusa, radicalmente differente dall'attuale adozione legale. Legata in modo imprescindibile alla sfera politica e sociale, essa permetteva a chi adottava di assicurarsi un erede ed una discendenza: spesso, inol...

 

2015 North East Lincolnshire Council election

2015 UK local government election Results by ward. The 2015 North East Lincolnshire Council election took place on 7 May 2015 to elect members of North East Lincolnshire Council in England.[1] This was on the same day as other local elections and the general election for the House of Commons of the United Kingdom. Council make up After the 2015 local election, the political make up of the council was as follows:[2] Party Number of councillors Labour 20 Conservative 10 Liberal ...

Fun Spot Amusement Park & Zoo

Fun Spot Amusement Park & ZooLocationAngola, Indiana, United StatesCoordinates41°40′35″N 85°01′47″W / 41.676462°N 85.029787°W / 41.676462; -85.029787StatusDefunctOpened1956Closed2008OwnerLee WrightSloganWhere Tigers MeetOperating seasonJune through August (now closed)AreaunknownAttractionsTotal30Roller coasters3Water rides1 Afterburner rollercoaster Fun Spot Amusement Park & Zoo was an amusement park located in Angola, Indiana. Although it was small...

 

Nuri-macan

Nuri-macan Psittacella Male Brehm's tiger parrotTaksonomiKelasAvesOrdoPsittaciformesFamiliPsittacidaeGenusPsittacella SpeciesFour; see text Nuri-macan adalah anggota genus Psittacella (satu-satunya genus di subfamili Psittacellinae ) dalam keluarga Psittaculidae, dinamai berdasarkan punggungnya yang bergaris harimau. Genus ini dicetuskan oleh Hermann Schlegel pada tahun 1871, genus ini berisi spesies berikut, yang semuanya endemik di pulau papua . Nuri-macan Madarasz ( Psittacella madaraszi )...