瑞司美替罗

瑞司美替罗
法律規範狀態
法律規範
  • Investigational
识别信息
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C17H12Cl2N6O4
摩尔质量435.22 g·mol−1
3D模型（JSmol（英语：JSmol））
  • CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl

瑞司美替罗（Resmetirom）是一种用于治疗非酒精性脂肪性肝炎(NASH) 的实验性药物。[1][2]它是甲状腺激素受体-β的选择性激动剂，可增加肝脏脂肪代谢并降低身体中过量脂肪的毒性。 [1]

截至2023年，处于III期临床试验阶段。 [3] [4]

参考文献

  1. ^ 1.0 1.1 Harrison SA, Bashir MR, Guy CD, Zhou R, Moylan CA, Frias JP, et al. Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet. November 2019, 394 (10213): 2012–2024. PMID 31727409. S2CID 207976212. doi:10.1016/S0140-6736(19)32517-6. 
  2. ^ Non-Alcoholic Fatty Liver Disease (NAFLD) Marketed and Pipeline Drugs Assessment, Clinical Trials and Competitive Landscape. Yahoo! Finance. January 23, 2023 [2023-05-15]. （原始内容存档于2023-02-07）. 
  3. ^ Harrison SA. A 52-Week Phase 3 Clinical Trial of Resmetirom in 180 Patients with Well-Compensated NASH Cirrhosis. AASLD: The Liver Meeting. [2023-05-15]. （原始内容存档于2023-05-27）. 
  4. ^ Madrigal Announces Positive Topline Results from the Pivotal Phase 3 MAESTRO-NASH Clinical Trial of Resmetirom for the Treatment of NASH and Liver Fibrosis (新闻稿). Madrigal Pharmaceuticals. December 19, 2022 [2023-05-15]. （原始内容存档于2023-12-16）.