敌鼠

敌鼠
Structural formula of diphenadione
Ball-and-stick model of the diphenadione molecule
IUPAC名
2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione
识别
CAS号 82-66-6  checkY
PubChem 6719
ChemSpider 6463
SMILES
 
  • O=C2c1ccccc1C(=O)C2C(=O)C(c3ccccc3)c4ccccc4
InChI
 
  • 1/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H
InChIKey JYGLAHSAISAEAL-UHFFFAOYAR
KEGG D07136
性质
化学式 C23H16O3
摩尔质量 340.37 g·mol−1
药理学
ATC代码 B01AA10（B01）
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。
「Diphenadione」的各地常用名稱
中国大陸敌鼠
臺灣得伐鼠
港澳敵鼠

敌鼠（英語：Diphenadione）是一種維生素K拮抗劑，具有抗凝血作用，可用作殺鼠劑對抗大鼠、小鼠、田鼠、地鬆鼠和其他囓齒動物。它是一種抗凝劑，其活性半衰期比華法林和其他合成1,3-茚滿二酮抗凝劑更長。[1][2]

它對所有形式的哺乳動物都有毒；毒素的暴露和口服攝入可能導致心律不齊和與其對凝血影響相關的主要疾病，具體取決於劑量。[3]作為“第二代”抗凝劑，敌鼠比第一代化合物（如華法林）毒性更大。[4]:436

參考資料

  1. ^ EXTOXNET Staff. Diphacinone. EXTOXNET. 1993-09-01 [2011-12-07]. （原始内容存档于2020-06-20）. 
  2. ^ Meister, R.T. (ed.). 1992. Farm Chemicals Handbook '92. Meister Publishing Company, Willoughby, OH.
  3. ^ Bell Laboratories, Inc. July, 1990. Diphacinone Technical: MSDS. Bell Labs, Madison, WI.
  4. ^ Murphy, Michael J.; Talcott, Patricia A. Anticoagulant Rodenticides (Ch. 32). Peterson, Michael E.; Talcott, Patricia A. (编). Small Animal Toxicology 3rd. St. Louis, MO, US: Elsevier Health Sciences. 2013: 435–446, esp. 435–439 [5 April 2016]. ISBN 978-0323241984. 

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