催乳素受体

prolactin receptor 催乳素受体
識別
符號 PRLR
Entrez 5618
HUGO 9446
OMIM 176761
PDB 1RW5
RefSeq NM_000949
UniProt P16471
其他資料
基因座 5 p13-p12

催乳素受体(英語:prolactin receptor)由染色体5p13-14区段的基因编码,作为一种跨膜受体催乳素相互作用。

它包括一个胞外区以结合催乳素,一个跨膜区,以及一个胞内区域。

该受体属于细胞因子受体[1],其第二信使信号通过JAK-STAT信号通路、JAK-RUSH信号通路[2][3]、Ras-Raf-MAPK和PI-3K[4]途径级联放大。

不同组织的催乳素受体可能会有所变化[5]

参考文献

  1. ^ Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
  2. ^ Helmer, Rebecca A.; Panchoo, Marlyn; Dertien, Janet S.; Bhakta, Suhani M.; Hewetson, Aveline; Chilton, Beverly S. Prolactin-induced Jak2 phosphorylation of RUSH: A key element in Jak/RUSH signaling. Molecular and Cellular Endocrinology. 2010-08, 325 (1-2): 143–149. PMC 2902710可免费查阅. PMID 20562009. doi:10.1016/j.mce.2010.05.010 (英语). 
  3. ^ Helmer, Rebecca A.; Dertien, Janet S.; Chilton, Beverly S. Prolactin induces Jak2 phosphorylation of RUSHY195. Molecular and Cellular Endocrinology. 2011-05, 338 (1-2): 79–83 [2021-11-10]. doi:10.1016/j.mce.2011.03.009. (原始内容存档于2018-06-02) (英语). 
  4. ^ Clevenger, Charles V.; Furth, Priscilla A.; Hankinson, Susan E.; Schuler, Linda A. The Role of Prolactin in Mammary Carcinoma. Endocrine Reviews. 2003-02-01, 24 (1): 1–27 [2021-11-10]. ISSN 0163-769X. PMC 1698952可免费查阅. PMID 12588805. doi:10.1210/er.2001-0036. (原始内容存档于2022-03-14) (英语). 
  5. ^ Binart, Nadine; Bachelot, Anne; Bouilly, Justine. Impact of prolactin receptor isoforms on reproduction. Trends in Endocrinology & Metabolism. 2010-06, 21 (6): 362–368 [2021-11-10]. doi:10.1016/j.tem.2010.01.008. (原始内容存档于2020-03-02) (英语). 

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