Метіоніл-тРНК-синтаза

Метіоніл-тРНК-синтаза
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи MARS1, METRS, MRS, MTRNS, SPG70, CMT2U, ILFS2, ILLD, methionyl-tRNA synthetase, methionyl-tRNA synthetase 1, MARS, TTD9
Зовнішні ІД OMIM: 156560 MGI: 1345633 HomoloGene: 90878 GeneCards: MARS1
Пов'язані генетичні захворювання
Charcot-Marie-Tooth disease axonal type 2U, severe early-onset pulmonary alveolar proteinosis due to MARS deficiency[1]
Шаблон експресії


Більше даних
Ортологи
Види Людина Миша
Entrez
Ensembl
UniProt
RefSeq (мРНК)
NM_004990
NM_001003913
NM_001171582
RefSeq (білок)
NP_004981
NP_001003913
NP_001165053
Локус (UCSC) Хр. 12: 57.48 – 57.52 Mb Хр. 10: 127.13 – 127.15 Mb
PubMed search [2] [3]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

Метіоніл-тРНК-синтаза (англ. Methionyl-tRNA synthetase) – білок, який кодується геном MARS, розташованим у людей на короткому плечі 12-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 900 амінокислот, а молекулярна маса — 101 116[5].

Послідовність амінокислот
1020304050
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPV
LQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAAL
YYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWG
ALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRP
YLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPL
RPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNIS
FDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRF
VEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHL
FLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLK
WGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQ
FMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNL
GNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVR
IRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAA
LLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSP
LFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVT
KQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK

Цей білок за функціями належить до лігаз, аміноацил-тРНК-синтетаз. Задіяний у такому біологічному процесі як біосинтез білка. Білок має сайт для зв'язування з АТФ, нуклеотидами, РНК, тРНК. Локалізований у цитоплазмі.

Література

  • Lage H., Dietel M. (1996). Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase. Gene. 178: 187—189.  PMID 8921912 DOI:10.1016/0378-1119(96)00313-7
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004.  PMID 15489334 DOI:10.1101/gr.2596504

Примітки

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