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Src
Наявні структури
PDB	Пошук ортологів: PDBe RCSB
Список кодів PDB
	1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4F, 1O4G, 1O4H, 1O4I, 1O4J, 1O4K, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 1O4R, 1SHD, 1Y57, 1YI6, 1YOJ, 1YOL, 1YOM, 2BDF, 2H8H, 3VRO, 3ZMP, 3ZMQ, 4F59, 4F5A, 4F5B, 4HXJ, 4K11, 4MXO, 4MXX, 4MXY, 4MXZ
Ідентифікатори
Символи	SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6
Зовнішні ІД	OMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC
шифр КФ	2.7.10.2
Реагує на сполуку
	бозутиніб, Дазатиніб, saracatinib, SU6656, saracatinib, PD166285
Онтологія гена
Молекулярна функція	• transmembrane transporter binding; • protein domain specific binding; • GO:0032403 protein-containing complex binding; • SH2 domain binding; • kinase activity; • signaling receptor binding; • estrogen receptor binding; • ATP binding; • protein kinase activity; • insulin receptor binding; • non-membrane spanning protein tyrosine kinase activity; • kinase binding; • heme binding; • enzyme binding; • transferase activity; • ephrin receptor binding; • scaffold protein binding; • integrin binding; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • cell adhesion molecule binding; • protein kinase C binding; • hormone receptor binding; • nucleotide binding; • growth factor receptor binding; • phosphoprotein binding; • protein tyrosine kinase activity; • protein C-terminus binding; • ubiquitin protein ligase binding; • cadherin binding; • connexin binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Клітинна компонента	• цитоплазма; • гіалоплазма; • мембрана; • extrinsic component of cytoplasmic side of plasma membrane; • ruffle membrane; • мітохондрія; • perinuclear region of cytoplasm; • caveola; • neuron projection; • цитоскелет; • клітинне ядро; • лізосома; • екзосома; • late endosome; • клітинна мембрана; • мікрофіламент; • GO:0097483, GO:0097481 постсинаптичне ущільнення; • мітохондріальна внутрішня мембрана; • podosome; • нуклеоплазма; • glutamatergic synapse; • postsynaptic specialization, intracellular component;
Біологічний процес	• response to mineralocorticoid; • negative regulation of telomere maintenance via telomerase; • response to interleukin-1; • positive regulation of MAP kinase activity; • positive regulation of canonical Wnt signaling pathway; • negative regulation of telomerase activity; • cellular response to progesterone stimulus; • regulation of intracellular estrogen receptor signaling pathway; • stress fiber assembly; • positive regulation of protein serine/threonine kinase activity; • platelet activation; • positive regulation of smooth muscle cell migration; • protein phosphorylation; • regulation of vascular permeability; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of ERK1 and ERK2 cascade; • regulation of podosome assembly; • клітинний цикл; • substrate adhesion-dependent cell spreading; • osteoclast development; • проліферація; • transforming growth factor beta receptor signaling pathway; • cellular response to hypoxia; • cellular response to transforming growth factor beta stimulus; • negative regulation of protein homooligomerization; • positive regulation of protein kinase B signaling; • positive regulation of lamellipodium morphogenesis; • epidermal growth factor receptor signaling pathway; • branching involved in mammary gland duct morphogenesis; • Fc-gamma receptor signaling pathway involved in phagocytosis; • negative regulation of intrinsic apoptotic signaling pathway; • negative regulation of extrinsic apoptotic signaling pathway; • response to mechanical stimulus; • response to virus; • positive regulation of epithelial cell migration; • signal complex assembly; • stimulatory C-type lectin receptor signaling pathway; • positive regulation of platelet-derived growth factor receptor signaling pathway; • Оогенез; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of epithelial cell migration; • response to nutrient levels; • positive regulation of DNA biosynthetic process; • cellular response to insulin stimulus; • protein autophosphorylation; • GO:0022415 viral process; • negative regulation of focal adhesion assembly; • response to acidic pH; • response to fatty acid; • regulation of cell projection assembly; • фосфорилювання; • процес імунної системи; • negative regulation of mitochondrial depolarization; • positive regulation of integrin activation; • negative regulation of apoptotic process; • cellular response to platelet-derived growth factor stimulus; • positive regulation of podosome assembly; • positive regulation of glucose metabolic process; • Цитопемпсис; • cellular response to fluid shear stress; • response to electrical stimulus; • positive regulation of protein transport; • uterus development; • protein destabilization; • regulation of cell-cell adhesion; • peptidyl-tyrosine autophosphorylation; • integrin-mediated signaling pathway; • GO:1903106 positive regulation of insulin receptor signaling pathway; • progesterone receptor signaling pathway; • GO:0045996 negative regulation of transcription, DNA-templated; • adherens junction organization; • negative regulation of anoikis; • response to hydrogen peroxide; • leukocyte migration; • activation of protein kinase B activity; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • GO:0007243 intracellular signal transduction; • regulation of early endosome to late endosome transport; • ephrin receptor signaling pathway; • T cell costimulation; • GO:0010740 positive regulation of intracellular signal transduction; • regulation of caveolin-mediated endocytosis; • regulation of cell cycle; • positive regulation of phosphatidylinositol 3-kinase activity; • GO:0072353 cellular response to reactive oxygen species; • cellular response to peptide hormone stimulus; • GO:1901313 positive regulation of gene expression; • cellular response to fatty acid; • regulation of cell population proliferation; • angiotensin-activated signaling pathway involved in heart process; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of protein autophosphorylation; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • positive regulation of apoptotic process; • forebrain development; • regulation of protein binding; • cellular response to lipopolysaccharide; • regulation of bone resorption; • cell migration; • GO:0072468 сигнальна трансдукція; • positive regulation of cell adhesion; • адгезія клітин; • positive regulation of protein processing; • вроджений імунітет; • positive regulation of peptidyl-tyrosine phosphorylation; • neurotrophin TRK receptor signaling pathway; • positive regulation of small GTPase mediated signal transduction; • кісткова резорбція; • central nervous system development; • positive regulation of protein localization to nucleus; • platelet-derived growth factor receptor signaling pathway; • ERBB2 signaling pathway; • intracellular estrogen receptor signaling pathway; • axon guidance; • macroautophagy; • peptidyl-tyrosine phosphorylation; • entry of bacterium into host cell; • cell-cell adhesion; • primary ovarian follicle growth; • positive regulation of ovarian follicle development; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of phosphatidylinositol 3-kinase signaling; • диференціація клітин; • phosphatidylinositol phosphate biosynthetic process; • regulation of postsynaptic neurotransmitter receptor activity; • positive regulation of non-membrane spanning protein tyrosine kinase activity; • G protein-coupled receptor signaling pathway; • cellular response to hydrogen peroxide; • positive regulation of platelet-derived growth factor receptor-beta signaling pathway; • odontogenesis;
	Джерела:Amigo / QuickGO
Шаблон експресії
	; ;
	Більше даних
Ортологи
	6714
	20779
	ENSG00000197122
	ENSMUSG00000027646
	P12931
	P05480
	NM_005417; NM_198291
	NM_001025395; NM_009271
	NP_005408; NP_938033
	NP_001020566; NP_033297
	Вікідані
Див./Ред. для людей	Див./Ред. для мишей

Src (англ. SRC proto-oncogene, non-receptor tyrosine kinase) – білок, який кодується геном SRC, розташованим у людини на довгому плечі 20-ї хромосоми.^[4] Довжина поліпептидного ланцюга білка становить 536 амінокислот, а молекулярна маса — 59 835^[5].

Послідовність амінокислот

10	20	30	40	50
MGSNKSKPKD	ASQRRRSLEP	AENVHGAGGG	AFPASQTPSK	PASADGHRGP
SAAFAPAAAE	PKLFGGFNSS	DTVTSPQRAG	PLAGGVTTFV	ALYDYESRTE
TDLSFKKGER	LQIVNNTEGD	WWLAHSLSTG	QTGYIPSNYV	APSDSIQAEE
WYFGKITRRE	SERLLLNAEN	PRGTFLVRES	ETTKGAYCLS	VSDFDNAKGL
NVKHYKIRKL	DSGGFYITSR	TQFNSLQQLV	AYYSKHADGL	CHRLTTVCPT
SKPQTQGLAK	DAWEIPRESL	RLEVKLGQGC	FGEVWMGTWN	GTTRVAIKTL
KPGTMSPEAF	LQEAQVMKKL	RHEKLVQLYA	VVSEEPIYIV	TEYMSKGSLL
DFLKGETGKY	LRLPQLVDMA	AQIASGMAYV	ERMNYVHRDL	RAANILVGEN
LVCKVADFGL	ARLIEDNEYT	ARQGAKFPIK	WTAPEAALYG	RFTIKSDVWS
FGILLTELTT	KGRVPYPGMV	NREVLDQVER	GYRMPCPPEC	PESLHDLMCQ
CWRKEPEERP	TFEYLQAFLE	DYFTSTEPQY	QPGENL

A: Аланін

C: Цистеїн

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

H: Гістидин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

W: Триптофан

Y: Тирозин