Sinaptonemal kompleks

(A) Bir SC modeli.
Açıklama için metne bakınız.

Sinaptonemal kompleks (SC), mayoz bölünme sırasında, genetik çeşitliliğin sebebi olan kromozomal parça değişiminde kromozomların eşleşmesini sinapsisler aracılığıyla sağladığı düşünülen, iki homolog kromozom arasında bulunan, proteinlerden oluşan yapıdır.

Sinaptonemal kompleks, ilk olarak Montrose J. Moses tarafından 1956'da karides ve D. Fawcett tarafından güvercin, kedi ve insan spermatositlerinde bulunmuştur.

SYCP1 geni insanlarda 1. kromozomun 1p13 bölgesinde; SYCP2 geni 20. kromozomun 20q13.33 bölgesinde ve SYCP3 geni 12. kromozomun q kolunda bulunur.

Yapısı

Sinaptonemal kompleks, iki paralel yan bölge ve bir orta element diye bilinen üç yapıdan oluşur. 3 bileşeni şunlardır:

  • SC protein-1 (SYCP1),
  • SC protein-2 (SYCP2),
  • SC protein-3 (SYCP3).

Resimde de görüldüğü gibi, sinaptonemal kompleks öncelikle en çok bulunduğu SYCP3 ve SYCP2 tarafından yapılmış iki yan elementten ve yapıda en az olarak bulunan SYCP1 proteinden yapılmış iki yan elementin arasında bulunan orta elementten oluşmaktadır.

Sinaptonemal kompleksler, ışık mikroskobunda gümüşlü boyamalarla veya SYCP3 ya da SYCP2'yi işaretleyen immünofloresans tekniklerle görülebilirler.

Bu üçlü yapı, erkek ve dişi gametogenezinde, mayoz I'in pakiten evresinde görülürler. Pakiten evresi öncesi leptopende yan elementler oluşmaya başlar ve zigoten evresine kadar kendilerini eşlerler. Pakiten bittikten sonra, SC genellikle parçalanır ve artık görülmez.

SC düzenlemesi genellikle eşleşme ya da iki homolog kromozomun "sinapsis"inde oluşabilecek anormalliklerin görülmesini sağlayabilmektedir.

Erkek memelilerinin eşey kromozomlarında sadece bölgesel bir sinapsis görülür ve bu genellikle XY çiftindeki SC'in kısa bir bölümüdür.

Sinaptonemal kompleks, ökaryot organizmalardaki bazı önemli protein farklılıklardan dolayı biraz değişiklik gösterebilir.

Bazı organizmalar, ya bir SC taşır ya da onun merkezinde bulunan birkaç "rekombinasyon nodülü"nü bulundurur. Bu nodüllerin olgunlaşmış genetik çeşitlilik olayları ya da krosover sırasında meydana geldikleri düşünülmektedir.

Resim açıklaması

A çiziminde yan elementler (açık mavi), homolog kromozomların yan yana gelmesi ve uzunlamasına siyah olarak görülen sinapslar ve filamentleri oluşturması görülmektedir. Uzunlamasına olan filamentler toplanarak SC'nin orta elementini oluştururlar. Elipsoidal yapılar, rekombinasyon nodülleri olarak isimlendirilir ve SC'nin merkezinde yer alır.

Dış bağlantılar

Wikimedia Commons'ta Sinaptonemal kompleks ile ilgili ortam dosyaları bulunmaktadır.

Read other articles:

Kotabumi, Lampung Utara

KotabumiKecamatanTugu Payan EmasNegara IndonesiaProvinsiLampungKabupatenLampung UtaraPemerintahan • CamatIwan Sagitariza, S.I.P, M.H[1]Luas[2] • Total59,11 km2 (22,82 sq mi)Populasi (2021)[2] • Total55.458 jiwa • Kepadatan938/km2 (2,430/sq mi)Kode pos34511–34518Kode Kemendagri18.03.02 Desa/kelurahan9 kelurahan4 desa[3] Kotabumi adalah sebuah kecamatan sekaligus menjadi ibu kota kabu...

 

Mazaalai (satellite)

First Mongolian spacecraft MazaalaiMazaalai among three other deploying CubeSat in Birds-1 mission, the top-most of the batch.NamesBird MMNUMSAT-1Mission typeTechnology demonstrationEarth observationOperatorNational University of MongoliaCOSPAR ID1998-067MW SATCAT no.42822Mission duration24 months (planned)22 months, 3 days (achieved) Spacecraft propertiesSpacecraft type1U CubeSatManufacturerNational University of MongoliaLaunch mass1 kgDimensions10 x 10 x 10 cmPowerwatts Start of m...

 

Sledgehammer (lagu)

SledgehammerSingel oleh Fifth Harmonydari album ReflectionSisi-ABossDirilis28 Oktober 2014 (2014-10-28)Direkam2014StudioWindmark Recording Studios (Santa Monica)Genre Synth-pop EDM Durasi3:52Label Epic Syco Pencipta Jonas Jeberg Meghan Trainor Sean Douglas Produser Jeberg Harvey Mason Jr. Kronologi singel Fifth Harmony Boss (2014) Sledgehammer (2014) Worth It (2015) Sledgehammer adalah lagu yang direkam oleh girl grup asal Amerika Serikat Fifth Harmony untuk album studio pertama mereka, ...

AIBA

Artikel ini perlu dikembangkan agar dapat memenuhi kriteria sebagai entri Wikipedia.Bantulah untuk mengembangkan artikel ini. Jika tidak dikembangkan, artikel ini akan dihapus. Artikel ini tidak memiliki referensi atau sumber tepercaya sehingga isinya tidak bisa dipastikan. Tolong bantu perbaiki artikel ini dengan menambahkan referensi yang layak. Tulisan tanpa sumber dapat dipertanyakan dan dihapus sewaktu-waktu.Cari sumber: AIBA – berita · surat kabar · buku...

 

1860 United States presidential election in Texas

Election in Texas Main article: 1860 United States presidential election 1860 United States presidential election in Texas ← 1856 November 6, 1860 1872 →   Nominee John C. Breckinridge John Bell Party Southern Democratic Constitutional Union Home state Kentucky Tennessee Running mate Joseph Lane Edward Everett Electoral vote 4 0 Popular vote 47,548 15,438 Percentage 75.47% 24.50% County Results Breckinridge   50-60%   60-70% &...

 

2018 Ohio elections

Ohio elections, 2018 ← 2016 November 6, 2018 2020 → Elections in Ohio Federal government U.S. President 1804 1808 1812 1816 1820 1824 1828 1832 1836 1840 1844 1848 1852 1856 1860 1864 1868 1872 1876 1880 1884 1888 1892 1896 1900 1904 1908 1912 1916 1920 1924 1928 1932 1936 1940 1944 1948 1952 1956 1960 1964 1968 1972 1976 1980 1984 1988 1992 1996 2000 Dem 2004 Dem 2008 Dem Rep 2012 Rep 2016 Dem Rep 2020 Dem 2024 Rep U.S. Senate 1803 1807 1808 1808 (sp) 1809 (sp) 1810 (s...

Brigitte Zypries

German lawyer and politician Brigitte Zypries2014Minister for Economic Affairs and EnergyIn office27 January 2017 – 14 March 2018ChancellorAngela MerkelPreceded bySigmar GabrielSucceeded byPeter AltmaierMinister of JusticeIn office22 October 2002 – 17 October 2009ChancellorGerhard SchröderAngela MerkelPreceded byHerta Däubler-GmelinSucceeded bySabine Leutheusser-SchnarrenbergerParliamentary State Secretary for Aerospace AffairsIn office17 December 2013 – 26 ...

 

Henry Raeburn

Scottish portrait painter (1756–1823) Henry RaeburnRaeburn in a self-portrait, c. 1820BornHenry(1756-03-04)4 March 1756Stockbridge, Edinburgh, ScotlandDied8 July 1823(1823-07-08) (aged 67)Edinburgh, ScotlandNationalityScottishKnown forPortrait paintingSpouseAnn EdgarElectedFRSE, RSA, RAPatron(s)King George IV Sir Henry Raeburn RA RSA FRSE (/ˈreɪbərn/; 4 March 1756 – 8 July 1823) was a Scottish portrait painter. He served as Portrait Painter to King George IV in Scotla...

 

N,N-Didesmethyltamoxifen

Chemical compound N,N-DidesmethyltamoxifenClinical dataOther namesDinortamoxifenIdentifiers IUPAC name 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]ethanamine CAS Number80234-20-4PubChem CID3036172ChemSpider2300247KEGGC16548ChEBICHEBI:80556ChEMBLChEMBL1743350Chemical and physical dataFormulaC24H25NOMolar mass343.470 g·mol−13D model (JSmol)Interactive image SMILES CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN)/C3=CC=CC=C3 InChI InChI=1S/C24H25NO/c1-2-23(19-9-5-3-6-10-19)24(20-11-7-4-8-12-20)21-1...

Totalitarianism

Extreme form of authoritarianism Joseph Stalin (left), leader of the Union of Soviet Socialist Republics, and Adolf Hitler (right), leader of the German Reich—considered prototypical dictators of totalitarian regimes, of the left and right respectively Totalitarianism is a political system and a form of government that prohibits opposition political parties, disregards and outlaws the political claims of individual and group opposition to the state, and controls the public sphere and the pr...

 

Landgoed het Holtslag

Landgoed het Holtslag Landgoed het Holtslag is een voormalig landgoed in de Nederlandse gemeente Bronckhorst. Het enige dat er nog aan herinnert is het straatnaambordje Holtslagweg in de buurt van Toldijk. Het Holtslag wordt op 23 augustus 1401 vermeld als landgoed van de Heeren Bronkhorst, de graven van Limburg Stirum. Het kasteel Holtslag is gebouwd voor familie of een kind van de Heeren van Bronkhorst. Door Deryckz van Steinre is het tussen 1401 en 1442 verkocht aan Deryck Heyinck. Deze la...

 

Nišava District

District of Serbia District of Serbia in Southern and Eastern SerbiaNišava District Нишавски округNišavski okrugDistrict of Serbia Images from the Nišava DistrictLocation of the Nišava District within SerbiaCoordinates: 43°18′N 21°54′E / 43.300°N 21.900°E / 43.300; 21.900Country SerbiaRegionSouthern and Eastern SerbiaAdministrative centerNišGovernment • CommissionerPetar BabovićArea • Total2,729 km2 (1,054...

2022 All-Ireland Senior Football Championship

135th All-Ireland Senior Football Championship season 2022 All-Ireland Senior Football ChampionshipChampionship detailsDates16 April – 24 July 2022Teams33All-Ireland ChampionsWinning teamKerry (38th win)CaptainSeán O'SheaManagerJack O'ConnorAll-Ireland FinalistsLosing teamGalwayCaptainSeán KellyManagerPádraic JoyceProvincial ChampionsMunsterKerryLeinsterDublinUlsterDerryConnachtGalwayChampionship statisticsTop Scorer Shane Walsh (1–36)Player of the Year David Clifford← 2021 2023 ...

 

List of cameo appearances by Alfred Hitchcock

This article possibly contains original research. Please improve it by verifying the claims made and adding inline citations. Statements consisting only of original research should be removed. (April 2023) (Learn how and when to remove this message) In one of his trademark cameos, Hitchcock (right) boards the train in Metcalf after Farley Granger's character exits in Strangers on a Train (1951). English film director Alfred Hitchcock made cameo appearances in 40 of his 53 surviving major fil...

 

Connecticut Route 190

Highway in Connecticut Route 190Route informationMaintained by CTDOTLength28.27 mi[1] (45.50 km)Existed1932–presentMajor junctionsWest end Route 75 in SuffieldMajor intersections I-91 in Enfield Route 83 in Somers Route 32 in Stafford I-84 in UnionEast end Route 171 in Union LocationCountryUnited StatesStateConnecticutCountiesHartford, Tolland Highway system Connecticut State Highway System Interstate US State SSR SR Scenic ← Route ...

HC Škoda Plzeň

Ice hockey team HC Škoda PlzeňCityPlzeň, Czech RepublicLeagueCzech ExtraligaFounded1929 (1929)Home arenaLogspeed CZ Arena(Capacity: 8,236)ColoursBlue, white   General manager Martin StrakaHead coach Petr KořínekWebsitehcplzen.cz T. G. Masaryk Cup for the winner of the Czech Extraliga, 2013 HC Škoda Plzeň is a professional Czech ice hockey team based in Plzeň, Czech Republic and was founded in 1929. They currently play in the Czech Extraliga, with their homes games ...

 

تريستان إنغرام

هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (يونيو 2019) تريستان إنغرام معلومات شخصية الميلاد 25 مارس 1982 (42 سنة)  مواطنة المملكة المتحدة  الحياة العملية المهنة منسق موسيقى  اللغات الإنجليزية  المواقع المو�...

 

The Princess Who Never Smiled

Russian folk fairy taleThe Princess Who Never SmiledThe Princess Who Never Smiled, painting by Viktor VasnetsovFolk taleNameThe Princess Who Never SmiledAlso known as The Unsmiling Tsarevna The Tsarevna who Would not Laugh Aarne–Thompson groupingATU 559 (Making the Princess Laugh)RegionRussiaPublished inRussian Fairy Tales, by Alexander Afanasyev The Princess Who Never Smiled, The Unsmiling Tsarevna or The Tsarevna who Would not Laugh[1] (Russian: Царевна Несмеяна, Ts...

Mal Kluang

Mal KluangLokasiKluang, Johor, MalaysiaKoordinat2°02′24.5″N 103°19′13.8″E / 2.040139°N 103.320500°E / 2.040139; 103.320500Dibuka2008ArsitekMalJumlah toko160Parkir850Situs webwww.kluangmall.com Mal Kluang adalah sebuah mal di Kluang, Johor, Malaysia. Sejarah Mal ini dibuka pada tahun 2008.[1] Referensi ^ Home. Kluang Mall. Diakses tanggal 31 May 2019.  Pranala luar Mal Kluang di Facebook Artikel bertopik bangunan dan struktur di Malaysia ini ada...

 

Progress in artificial intelligence

How AI-related technologies evolve See also: History of artificial intelligence and Timeline of artificial intelligence Part of a series onArtificial intelligence Major goals Artificial general intelligence Intelligent agent Recursive self-improvement Planning Computer vision General game playing Knowledge reasoning Natural language processing Robotics AI safety Approaches Machine learning Symbolic Deep learning Bayesian networks Evolutionary algorithms Hybrid intelligent systems Systems inte...