QT uzaması

Uzun QT sendromu ya da QT Uzaması, Elektrokardiyografide gözlenen QT aralığının uzamasıdır. (kalbin “yeniden şarj olması” kabul edilen elektriksel birikme çok uzun sürer) Düzensiz bir şekilde devam ederse ölüme yol açabilecek düzensiz kalp ritimlerine neden olabilir. Bu sendrom, torsades de pointes (TdP) olarak da bilinen karakteristik, hayatı tehdit eden kalp aritmisi olan polimorfik ventriküler taşikardi riskindeki artışla ilişkilidir.[1]

Sendrom kalıtsal veya çevreseldir. Konjenital bozukluğa kalp kası hücre membranındaki iyon kanallarını kodlayan genlerdeki mutasyonlar yol açar. Çevresel form ise iyon kanalındaki bozukluk veya ilaçlar nedeniyle gelişir.[2]

Çevresel sendromuna yol açabilen bazı ilaçlar:[3]

Tedavi

Hipopotasemi, hipomagnezemi gibi elektrolit bozuklukları ve olası bradikardi tedavi edilmelidir. Beta blokörler günümüzde uzun QT sendromu hastalarında tercih edilen ilaç tedavisidir. Propranolol ve nadolol en sık tercih edilen beta blokörlerdir; metoprolol ve atenolol da uzun QT sendromunda kullanılabilmektedir.[4]

Kaynakça

  1. ^ "Arşivlenmiş kopya". 11 Ağustos 2021 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Ağustos 2021. 
  2. ^ "Arşivlenmiş kopya" (PDF). 11 Ağustos 2021 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 11 Ağustos 2021. 
  3. ^ "Arşivlenmiş kopya". 11 Ağustos 2021 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Ağustos 2021. 
  4. ^ "Arşivlenmiş kopya" (PDF). 22 Aralık 2018 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 11 Ağustos 2021. 

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