İndüklenmiş pluripotent kök hücre

İndüklenmiş pluripotent kök hücre (iPS hücresi olarak kısaltılabilir), pluripotent olmayan bir hücreden, bazı genleri üretmesi sağlanarak veya dışarıdan faktörler verilerek, farklılaşmanın tersine çevrilmesi sonucu elde edilen hücre.

İndüklenmiş pluripotent kök hücreler birçok yönüyle doğal pluripotent kök hücrelere (örn. embriyonik kök hücrelere) benzer. Örneğin farkılaşabilirler, blastokiste enjekte edildiğinde yeni oluşan bireyin vücut hücrelerine katkıda bulunabilirler ve yetişkin bir canlıda teratom oluşturabilirler.

iPS hücrelerinin oluşturulması

İlk iPS hücresi

İndüklenmiş pluripotent kök hücreler ilk olarak Shinya Yamanaka'nın çalışma grubu tarafından 2006 yılında Kyoto Üniversitesi'nde üretildi. Araştırmada, embryonik kök hücrelerde önemli olduğu saptanan transkripsiyon faktörlerinden 24 tanesi seçildi. Fare fibroblastlarına retroviral transfeksiyon yöntemiyle önce bunların tamamı akratılarak pluripotent hücreler elde edildi, daha sonra tek tek çıkarılarak en önemli 10 tanesi ve bunların içinden 4 tanesi seçildi. Fibroblastlara yalnızca bu 4 genin (Oct4, Sox2, c-Myc ve Klf4) aktarılmasının onları pluripotent hale getirmeye yettiği saptandı.[1]

Kaynakça

  1. ^ Takahashi K, Yamanaka S (2006). "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors". Cell. 126 (4). ss. 663-76. doi:10.1016/j.cell.2006.07.024. PMID 16904174. 6 Ocak 2012 tarihinde kaynağından arşivlendi. Erişim tarihi: 28 Aralık 2011. 

Read other articles:

Andrew S. Tanenbaum

Andrew Stuart TanenbaumLahirlahir 16 Maret 1944White Plains, New YorkTempat tinggalAmsterdam, BelandaKebangsaanAmerikaPekerjaanProfesorTempat kerjaVrije UniversiteitDikenal atasMINIX, Mikrokernel Andrew Stuart Andy Tanenbaum[1] lahir 16 Maret 1944, adalah seorang profesor di bidang ilmu komputer di Vrije Universiteit, Amsterdam di Belanda. Dia dikenal baik sebagai penulis MINIX, sebuah program sistem operasi bertipe Unix untuk tujuan pengajaran, dan juga atas buku nasnya tentang ilmu...

 

Harungguan, Bonatua Lunasi, Toba

HarungguanDesaKantor Kepala Desa HarungguanPeta lokasi Desa HarungguanNegara IndonesiaProvinsiSumatera UtaraKabupatenTobaKecamatanBonatua LunasiKode pos22386Kode Kemendagri12.12.23.2004 Luas3.00 km²Jumlah penduduk296 jiwa (2015)Kepadatan98,67 jiwa/km² Harungguan adalah salah satu desa di Kecamatan Bonatua Lunasi, Kabupaten Toba, Provinsi Sumatera Utara, Indonesia. Pemerintahan Kepala Desa Harungguan pada tahun 2021 adalah Posman Sitorus.[1] Desa Harungguan terdiri dari dusun: L...

 

Pemilihan umum Senat Amerika Serikat di Delaware 1990

Pemilihan umum Senat Amerika Serikat di Delaware 1990198419966 November 1990Kandidat   Calon Joe Biden M. Jane Brady Partai Demokrat Republik Suara rakyat 112.918 64.554 Persentase 62,7% 35,8% Peta persebaran suara Hasil berdasarkan kabupatenBiden:      50–60%      60–70% Senator Amerika Serikat petahanaJoe Biden Demokrat Senator Amerika Serikat terpilih Joe Biden Demokrat Pemilihan umum Senat Amerika Serikat di Delaware 1990 di...

Central Park

Untuk kegunaan lain, lihat Central Park (disambiguasi). Central ParkJenisTaman umum (Departemen Taman dan Rekreasi New York City)Lokasi Manhattan, New York City, Amerika SerikatKoordinat40°46′55″LU,73°57′58″BBDibuka1859Dioperasikan olehCentral Park ConservancyStatusSepanjang tahun Central Park adalah taman umum yang luas di Manhattan, New York City. Luasnya 3,41 km² dengan bentuk lahan persegi panjang (panjang 4 km, lebar 800 m). Setiap tahunnya, taman ini dikunjungi...

 

Wappo

Native American tribe in California For the language, see Wappo language. Wappo peopleA Wappo Woman from Edward S. Curtis Collection.Total population1770: 1,000–1,6501850: 188–2001910: 731977: 50[1]2000: 2502010: 291[2]Regions with significant populations California (Clear Lake, Napa Valley, Alexander Valley, Russian River Valley)LanguagesEnglish, historically Wappo[1]Religiontraditional tribal religionRelated ethnic groupsYuki people[3] The Wappo (end...

 

Jan Urban

Jan Urban Wawancara Jan Urban sebelum Lech Poznań - Górnik Zabrze, permainan Ekstraklasa, 2015Informasi pribadiNama lengkap Jan UrbanTanggal lahir (1962-05-14)14 Mei 1962Tempat lahir Jaworzno, PolandiaTinggi 1,79 m (5 ft 10+1⁄2 in)Posisi bermain StrikerKarier junior1980–1981 Victoria JaworznoKarier senior*Tahun Tim Tampil (Gol)1981–1985 Zagłębie Sosnowiec 113 (23)1985–1989 Górnik Zabrze 124 (54)1989–1994 Osasuna 168 (48)1995 Valladolid 21 (3)1995–1996 Tole...

Serrasalmidae

Keluarga Ikan PiranhaRentang fosil: Miosen - sekarang Pygocentrus nattereri Klasifikasi ilmiah Kerajaan: Animalia Filum: Chordata Subfilum: Vertebrata Kelas: Actinopterygii Superordo: Ostariophysi Ordo: Characiformes Famili: SerrasalmidaeBleeker, 1859 Genera[1] Acnodon Catoprion Colossoma Megapiranha (punah) Metynnis Mylesinus Myleus Myloplus Mylossoma Ossubtus Piaractus Pristobrycon Pygocentrus Pygopristis Serrasalmus Tometes Utiaritichthys Serrasalmidae atau Keluarga Ikan Piranha a...

 

Members of the New South Wales Legislative Council, 2019–2023

Members of the New South Wales Legislative Council who served in the 57th Parliament were elected at the 2015 and 2019 elections. As members serve eight-year terms, half of the Council was elected in 2015 and did not face re-election in 2019, and the members elected in 2019 will not face re-election until 2027.[1][2] The President was John Ajaka until March 2021 and then Matthew Mason-Cox from May 2021.[4] Name Party End term Years in office John Ajaka [d ...

 

Cookeville, Tennessee

Largest city and county seat of Putnam County, Tennessee, United States Cookeville redirects here. For other uses, see Cookeville (disambiguation). City in Tennessee, United StatesCookeville, TennesseeCityDowntown Cookeville, viewed from Dogwood Park LogoNickname(s): Hub of the Upper Cumberland,[1] Tennessee's College Town[2]Location of Cookeville in Putnam County, Tennessee.Coordinates: 36°9′51″N 85°30′15″W / 36.16417°N 85.50417°W / 36...

OPAL Soil Centre

The OPAL Soil Centre is one of five centres of expertise under the Open Air Laboratories Network (OPAL). The OPAL Soil Centre is based at the Centre for Environmental Policy at Imperial College London. The OPAL Soil Centre has high-profile partners including the Environment Agency, British Geological Survey, and the Natural History Museum. Soil and Earthworm Survey The OPAL Soil Centre developed the OPAL Soil and Earthworm Survey, a national public survey of the soil and earthworms in Englan...

 

Magnetospheric Multiscale Mission

Artikel ini perlu diwikifikasi agar memenuhi standar kualitas Wikipedia. Anda dapat memberikan bantuan berupa penambahan pranala dalam, atau dengan merapikan tata letak dari artikel ini. Untuk keterangan lebih lanjut, klik [tampil] di bagian kanan. Mengganti markah HTML dengan markah wiki bila dimungkinkan. Tambahkan pranala wiki. Bila dirasa perlu, buatlah pautan ke artikel wiki lainnya dengan cara menambahkan [[ dan ]] pada kata yang bersangkutan (lihat WP:LINK untuk keterangan lebih lanjut...

 

Harbin Z-20

Chinese medium-lift utility helicopter Z-20 Z-20 flying at Airshow China 2022 Role Medium lift helicopterType of aircraft National origin China Manufacturer Harbin Aircraft Industry Group First flight 23 December 2013 Introduction 1 October 2019[1] Status In service, in production[1] Primary users People's Liberation Army Ground ForcePeople's Liberation Army Naval Air Force People's Armed Police The Harbin Z-20 (Chinese: 直-20) is a Chinese medium-lift utility helico...

Simrishamn Municipality

Municipality in Skåne County, SwedenSimrishamn Municipality Simrishamns kommunMunicipalitySimrishamn Library Coat of armsCoordinates: 55°33′N 14°21′E / 55.550°N 14.350°E / 55.550; 14.350CountrySwedenCountySkåne CountySeatSimrishamnArea[1] • Total1,261.15 km2 (486.93 sq mi) • Land391.36 km2 (151.10 sq mi) • Water869.79 km2 (335.83 sq mi) Area as of 1 January 2014.Popu...

 

Barnaba (apostolo)

La neutralità di questa voce o sezione sull'argomento religiosi è stata messa in dubbio. Motivo: Voce biblica i cui toni enfatici delle diverse sezioni oltre a non mettere in opportuno rilievo la netta differenza fra il personaggio biblico e il personaggio della tradizione cattolica associato a volte a leggende, usa una persona di giudizi che non ha riscontro nelle note. Le note attualmente in voce riguardano infatti esclusivamente i riferimenti biblici al libro di Atti, una esclusivi...

 

Oxford

Pour les articles homonymes, voir Oxford (homonymie). Oxford Héraldique Administration Pays Royaume-Uni Nation Angleterre Région Angleterre du Sud-Est Comté Oxfordshire District Oxford Statut Cité (1542) Maire Lubna Arshad (depuis 2023) Code postal OX Indicatif (0)1865 Démographie Population 159 600 hab. (estimation 2015) Densité 3 501 hab./km2 Géographie Coordonnées 51° 45′ 07″ nord, 1° 15′ 28″ ouest Altitude 63,4 m Su...

Ethnoburb

Urban area with a specific ethnic minority Box Hill, Victoria contains a sizeable Chinese population. According to the 2016 Australian census, 35.4% of the suburb's population were of Chinese ancestry, 27.6% of the suburb's population was born in China, while 38.1% of the suburb's population spoke either Mandarin or Cantonese at home.[1] An ethnoburb is a suburban residential and business area with a notable cluster of a particular ethnic minority population, which may or may not be a...

 

昆山杜克大学

  提示：此条目页的主题不是崑山科技大學。 Duke Kunshan University昆山杜克大学创办时间2013年[1]学校标识码4132016406学校类型私立校长刘耀林常务副校长Mary Frances Luce (interim)学生人數1,400名本科生(2022年春)校址 中华人民共和国江苏省苏州市昆山市杜克大道8号校區郊区/城区隶属亚洲博雅大学联盟杜克大学武汉大学網站dukekunshan.edu.cn 位置 Duke Kunshan University繁体字 �...

 

Electoral fraud

Illegal interference with the process of an election The examples and perspective in this article may not represent a worldwide view of the subject. You may improve this article, discuss the issue on the talk page, or create a new article, as appropriate. (December 2022) (Learn how and when to remove this message) Political corruption Forms and concepts Bribery Cronyism Economics of corruption Electoral fraud Elite capture Influence peddling Kleptocracy Mafia state Nepotism Pyrrhic defeat the...

Pietro Tacca

La fontana di piazza Santissima Annunziata, Firenze Pietro Tacca (Carrara, 6 settembre 1577 – Firenze, 1640) è stato uno scultore italiano, il maggior rappresentante in Toscana del gusto barocco. Accademico dell'Accademia delle arti del disegno di Firenze. Indice 1 Biografia 2 Altre immagini 3 Bibliografia 4 Altri progetti 5 Collegamenti esterni Biografia A soli quindici anni entrò nella bottega del Giambologna (1592), lo scultore più importante dell'epoca a Firenze, del quale divenne il...

 

County Aransas, Texas

Aransas County, TexasLokasi di negara bagian TexasLokasi negara bagian Texas di Amerika SerikatDidirikan1871Asal namaThe Rio Nuestra Senora de Aranzazu, a Spanish outpost in early TexasSeatRockportKota terbesarRockportWilayah • Keseluruhan528 sq mi (1.367 km2) • Daratan252 sq mi (652 km2) • Perairan276 sq mi (715 km2), 52.29%Populasi • (2000)22.497 • Kepadatan89/sq mi (34/km²)Zona wa...