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UDP-N-acetilmuramoilalanin-D-glutamatska ligaza
UDP-N-acetilmuramoilalanin-D-glutamatska ligaza
Identifikatori
EC broj	6.3.2.9
CAS broj	9023-59-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

UDP-N-acetilmuramoilalanin-D-glutamatska ligaza (EC 6.3.2.9, MurD sintetaza, UDP-N-acetilmuramoil-L-alanil-D-glutamat sintetaza, uridin difosfo-N-acetilmuramoilalanil-D-glutamat sintetaza, enzim dodavanja D-glutamata, D-glutamatna ligaza, ''UDP-Mur-NAC-L-Ala:D-Glu ligaza, UDP-N-acetilmuramoil-L-alanin:glutamat ligaza (formira ADP), UDP-N-acetilmuramoilalanin—D-glutamat ligaza) je enzim sa sistematskim imenom UDP-N-acetilmuramoil-L-alanin:D-glutamat ligaza (formira ADP).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + UDP-N-acetilmuramoil-L-alanin + D-glutamat

\rightleftharpoons

ADP + fosfat + UDP-N-acetilmuramoil-L-alanil-D-glutamat

Ovaj enzim učestvuje u sintezi peptida ćelijskog zida.

Reference

^ Ito, E. & Strominger, J.L. (1962). „Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine”. J. Biol. Chem. 237: 2689—2695.
^ van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503—519. PMID 11699883.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

UDP-N-acetylmuramoyl-L-alanine---D-glutamate+ligase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Ito, E. & Strominger, J.L. (1962). „Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine”. J. Biol. Chem. 237: 2689—2695.

[2] van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503—519. PMID 11699883.

[1]

[2]