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Trimetilamin-korinoid protein Co-metiltransferaza
Trimetilamin-korinoid protein Co-metiltransferaza
Identifikatori
EC broj	2.1.1.250
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PubMed	članci
NCBI	proteini

Trimetilamin-korinoid protein Co-metiltransferaza (EC 2.1.1.250, mttB (gen), trimetilaminska metiltransferaza) je enzim sa sistematskim imenom trimetilamin:5-hidroksibenzimidazolilkobamid Co-metiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

trimetilamin + [Co(I) trimetilamin-specifični korinoidni protein]

\rightleftharpoons

[metil-Co(III) trimetilamin-specifični korinoidni protein] + dimetilamin

Enzim, koji katalizuje transfer metil grupe sa trimetilamina na trimetilamin-specifični korinoidni protein (MttC), učestvuje u metanogenezi. Ovaj enzim sadrži neobičnu aminokiselinu pirolizin.

Reference

^ Ferguson, D.J., Jr. & Krzycki, J.A. (1997). „Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri”. J. Bacteriol. 179: 846—852. PMID 9006042.
^ Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484—491. PMID 15450490.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Trimethylamine-corrinoid+protein+Co-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Ferguson, D.J., Jr. & Krzycki, J.A. (1997). „Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri”. J. Bacteriol. 179: 846—852. PMID 9006042.

[2] Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484—491. PMID 15450490.

[1]

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