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Fosforibozilglicinamid formiltransferaza
Fosforibozilglicinamid formiltransferaza
Identifikatori
EC broj	2.1.2.2
CAS broj	2604945
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Fosforibozilglicinamid formiltransferaza (EC 2.1.2.2, 2-amino-N-ribozilacetamid 5'-fosfatna transformilaza, GAR formiltransferaza, GAR transformilaza, glicinamid ribonukleotidna transformilaza, GAR TFaza, 5,10-meteniltetrahidrofolat:2-amino-N-ribozilacetamid ribonukleotid transformilaza) je enzim sa sistematskim imenom 10-formiltetrahidrofolat:5'-fosforibozilglicinamid N-formiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

10-formiltetrahidrofolat + N¹-(5-fosfo-D-ribozil)glicinamid

\rightleftharpoons

tetrahidrofolat + N²-formil-N¹-(5-fosfo-D-ribozil)glicinamid

Reference

^ Hartman, S.C. & Buchanan, J.M. (1959). „Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reaction”. J. Biol. Chem. 234: 1812—1816. PMID 13672969.
^ Smith, G.K., Benkovic, P.A. and Benkovic, S.J. (1981). „L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver”. Biochemistry. 20: 4034—4036. PMID 7284307.
^ Warren, L. & Buchanan, J.M. (1957). „Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5′-phosphate (glycinamide ribotide) transformylase”. J. Biol. Chem. 229: 613—626. PMID 13502326.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Vidi još

Trifunkcioni purinski biosintetički protein adenozin-3

Spoljašnje veze

Phosphoribosylglycinamide+formyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hartman, S.C. & Buchanan, J.M. (1959). „Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reaction”. J. Biol. Chem. 234: 1812—1816. PMID 13672969.

[2] Smith, G.K., Benkovic, P.A. and Benkovic, S.J. (1981). „L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver”. Biochemistry. 20: 4034—4036. PMID 7284307.

[3] Warren, L. & Buchanan, J.M. (1957). „Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5′-phosphate (glycinamide ribotide) transformylase”. J. Biol. Chem. 229: 613—626. PMID 13502326.

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