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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Timidin fosforilaza
Timidin fosforilaza
Identifikatori
EC broj	2.4.2.4
CAS broj	9030-23-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Timidin fosforilaza (EC 2.4.2.4, pirimidinska fosforilaza, timidin-ortofosfatna dezoksiriboziltransferaza, regulatori životinjskog rasta, endotelni faktori ćelijskog rasta izvedeni iz krvnih trombocita, endotelni faktori ćelijskog rasta izvedeni iz krvnih trombocita, dezoksitimidinska fosforilaza, gliostatini, pirimidin dezoksinukleozidna fosforilaza, timidin:fosfat dezoksi-D-riboziltransferaza) je enzim sa sistematskim imenom timidin:fosfat dezoksi-alfa-D-riboziltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

timidin + fosfat

\rightleftharpoons

timin + 2-dezoksi-alfa-D-riboza 1-fosfat

Enzim u pojedinim tkivima takođe katalizuje reakcije dezoksiriboziltransferaze.

Reference

^ Friedkin, M. & Roberts, D. (1954). „The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue”. J. Biol. Chem. 207: 245—256. PMID 13152099.
^ Zimmerman, M. & Seidenberg, J. (1964). „Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues”. J. Biol. Chem. 239: 2618—2621. PMID 14235544.
^ Zimmerman, M. (1964). „Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases”. J. Biol. Chem. 239: 2622—2627. PMID 14235545.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Thymidine+phosphorylase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Friedkin, M. & Roberts, D. (1954). „The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue”. J. Biol. Chem. 207: 245—256. PMID 13152099.

[2] Zimmerman, M. & Seidenberg, J. (1964). „Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues”. J. Biol. Chem. 239: 2618—2621. PMID 14235544.

[3] Zimmerman, M. (1964). „Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases”. J. Biol. Chem. 239: 2622—2627. PMID 14235545.

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