Tetrahidrofolatna sintaza

Tetrahidrofolatna sintaza
Identifikatori
EC broj6.3.2.17
CAS broj63363-84-8
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Tetrahidrofolatna sintaza (EC 6.3.2.17, folilpoliglutamatna sintaza, folat poliglutamatna sintetaza, formiltetrahidropteroildiglutamatna sintetaza, N10-formiltetrahidropteroildiglutamat sintetaza, folilpoli-gama-glutamatna sintaza, folilpoliglutamil sintetaza, folilpoli(gama-glutamat) sintaza, folilpoliglutamatna sintetaza, folilpoli-gama-glutamat sintetaza-dihidrofolatna sintetaza, FPGS, tetrahidrofolilpoliglutamat sintaza, tetrahidrofolat:L-glutamat gama-ligaza (formira ADP), tetrahidropteroil-(gama-Glu)n:L-glutamat gama-ligaza (formira ADP)) je enzim sa sistematskim imenom tetrahidropteroil-gama-poliglutamat:L-glutamat gama-ligaza (formira ADP).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + tetrahidropteroil-[gama-Glu]n + L-glutamat ADP + fosfat + tetrahidropteroil-[gama-Glu]n+1

Kod pojedinih bakterija, isti protein katalizuje ovu reakciju i reakciju enzima EC 6.3.2.12.

Reference

  1. ^ Cichowicz, D., Foo, S.K. and Shane, B. (1981). „Folylpoly-γ-glutamate synthesis by bacteria and mammalian cells”. Mol. Cell. Biochem. 39: 209—228. PMID 6458762. 
  2. ^ McGuire, J.J. & Bertino, J.R. (1981). „Enzymatic synthesis and function of folylpolyglutamates”. Mol. Cell. Biochem. 38: 19—48. PMID 7027025. 
  3. ^ Bognar, A.L., Osborne, C., Shane, B., Singer, S.C. and Ferone, R. (1985). „Folylpoly-γ-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product”. J. Biol. Chem. 260: 5625—5630. PMID 2985605. 
  4. ^ Ravanel, S., Cherest, H., Jabrin, S., Grunwald, D., Surdin-Kerjan, Y., Douce, R. and Rébeillé, F. (2001). „Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana”. Proc. Natl. Acad. Sci. USA. 98: 15360—15365. PMID 11752472. 
  5. ^ Cossins, E.A. & Chen, L. (1997). „Folates and one-carbon metabolism in plants and fungi”. Phytochemistry. 45: 437—452. PMID 9190084. 
  6. ^ Cherest, H., Thomas, D. and Surdin-Kerjan, Y. (2000). „Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae”. J. Biol. Chem. 275: 14056—14063. PMID 10799479. 

Literatura

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