Tau-protein kinaza

Tau-protein kinaza
Identifikatori
EC broj2.7.11.26
CAS broj111694-09-8
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Tau-protein kinaza (EC 2.7.11.26, ATP:tau-protein O-hosfotransferaza, moždana proteinska kinaza PK40erk, cdk5/p20, CDK5/p23, glikogenska sintaza kinaza-3beta, GSK, protein tau kinaza, STK31, tau kinaza, tau-protein kinaza I, tau-protein kinaza II, tau-tubulin kinaza, TPK, TPK I, TPK II, TTK) je enzim sa sistematskim imenom ATP:(tau-protein) O-fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [tau-protein] ADP + O-fosfo-[tau-protein]

Ovaj enzim se aktivira tubulinom.

Reference

  1. ^ Ishiguro, K., Ihara, Y., Uchida, T. and Imahori, K. (1988). „A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau”. J. Biochem. (Tokyo). 104: 319—321. PMID 2467901. 
  2. ^ Lund, E.T., McKenna, R., Evans, D.B., Sharma, S.K. and Mathews, W.R. (2001). „Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry”. J. Neurochem. 76: 1221—1232. PMID 11181841. 
  3. ^ Michel, G., Mercken, M., Murayama, M., Noguchi, K., Ishiguro, K., Imahori, K. and Takashima, A. (1998). „Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells”. Biochim. Biophys. Acta. 1380: 177—182. PMID 9565682. 
  4. ^ Aoki, M., Iwamoto-Sugai, M., Sugiura, I., Sasaki, C., Hasegawa, T., Okumura, C., Sugio, S., Kohno, T. and Matsuzaki, T. (2000). „Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta”. Acta Crystallogr. D Biol. Crystallogr. 56: 1464—1465. PMID 11053853. 

Literatura

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