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G protein spregnuti receptor kinaza
G protein spregnuti receptor kinaza
Identifikatori
EC broj	2.7.11.16
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Ontologija gena	AmiGO / EGO
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

G protein spregnuti receptor kinaze (GRK, GPCRK) su familija proteinskih kinaza koje regulišu aktivnost G protein-spregnutih receptora putem fosforilacije njihovih intracelularnih domena, nakon što se njihovi vezani G proteini odvojeni i aktivirani.

Fosforilisani ostaci serina i treonina dejstvuju kao mesta vezivanja proteina arestina, koji sprečavaju ponovno vezivanje G proteina sa njihovim receptorima. Na taj način oni sprečavaju reaktivaciju signalnog puta.^[1]

GRK tipovi

Ime	Napomene	Gen	OMIM
G protein spregnuti receptor kinaza 1	Rodopsinska kinaza	GRK1	180381
G protein spregnuti receptor kinaza 2	β-Adrenergički receptor kinaza1 (BARK1)	ADRBK1 (GRK2)	109635
G protein spregnuti receptor kinaza 3	β-Adrenergički receptor kinaza 2 (BARK2)	ADRBK2 (GRK3)	109636
G protein spregnuti receptor kinaza 4	Smatra se da učestvuje u regulacionim funkcijama tubula bugrega	GRK4	137026
G protein spregnuti receptor kinaza 5	Nokaut miševi imaju izmenjenu normalnu temperaturu tela	GRK5	600870
G protein spregnuti receptor kinaza 6	Nokaut miševi su izuzetno senzitivni na dopaminergike^[2]	GRK6	600869
G protein spregnuti receptor kinaza 7	Opsinska kinaza	GRK7	606987

^ Ribas C, Penela P, Murga C, Salcedo A, García-Hoz C, Jurado-Pueyo M, Aymerich I, Mayor F (2007). „The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling”. Biochimica et Biophysica Acta. 1768 (4): 913—22. PMID 17084806. doi:10.1016/j.bbamem.2006.09.019.
^ Gainetdinov RR; Bohn LM; Sotnikova TD; et al. (2003). „Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice”. Neuron. 38 (2): 291—303. PMID 12718862. doi:10.1016/S0896-6273(03)00192-2. Приступљено 14. 8. 2009.

Sobierajska K, Fabczak H, Fabczak S (2005). „Mechanisms of Regulation and Function of G Protein-Coupled Receptor Kinases]”. Postepy Biochemii (на језику: Polish). 51 (4): 421—9. PMID 16676577.
Ma L, Gao J, Chen X (2005). „G Protein-Coupled Receptor Kinases”. Ур.: Devi LA. The G Protein-Coupled Receptors Handbook (Contemporary Clinical Neuroscience). Totowa, NJ: Humana Press.
Kurose H (2000). „G Protein-Coupled Kinases and Desensitization of Receptors”. Ур.: Bernstein G, Tatsuya H. G protein-coupled receptors. Boca Raton: CRC Press.
Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.