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tRNK (adenin⁵⁸-N¹)-metiltransferaza
tRNK (adenin58-N1)-metiltransferaza
Identifikatori
EC broj	2.1.1.220
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

tRNK (adenin⁵⁸-N¹)-metiltransferaza (EC 2.1.1.220, tRNK m1A58 metiltransferaza, tRNK (m1A58) metiltransferaza, TrmI, tRNK (m1A58) MTaza, Rv2118cp, Gcd10p-Gcd14p, Trm61p-Trm6p) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (adenin⁵⁸-N¹)-metiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + adenin⁵⁸ u tRNK

\rightleftharpoons

S-adenozil-L-homocistein + N¹-metiladenin⁵⁸ u tRNK

Ovaj enzim specifično metiluje adenin⁵⁸ u tRNK. Metilacija A58 je kritična za održavanje stabilnosti inicijatora tRNKMet kod kvasca.

Reference

^ Droogmans, L., Roovers, M., Bujnicki, J.M., Tricot, C., Hartsch, T., Stalon, V. and Grosjean, H. (2003). „Cloning and characterization of tRNA (m¹A⁵⁸) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures”. Nucleic Acids Res. 31: 2148—2156. PMID 12682365.
^ Varshney, U., Ramesh, V., Madabushi, A., Gaur, R., Subramanya, H.S. and RajBhandary, U.L. (2004). „Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m¹A⁵⁸ tRNA methyltransferase”. Nucleic Acids Res. 32: 1018—1027. PMID 14960715.
^ Anderson, J., Phan, L. and Hinnebusch, A.G. (2000). „The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae”. Proc. Natl. Acad. Sci. USA. 97: 5173—5178. PMID 10779558.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

TRNA+(adenine58-N1)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Droogmans, L., Roovers, M., Bujnicki, J.M., Tricot, C., Hartsch, T., Stalon, V. and Grosjean, H. (2003). „Cloning and characterization of tRNA (m¹A⁵⁸) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures”. Nucleic Acids Res. 31: 2148—2156. PMID 12682365.

[2] Varshney, U., Ramesh, V., Madabushi, A., Gaur, R., Subramanya, H.S. and RajBhandary, U.L. (2004). „Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m¹A⁵⁸ tRNA methyltransferase”. Nucleic Acids Res. 32: 1018—1027. PMID 14960715.

[3] Anderson, J., Phan, L. and Hinnebusch, A.G. (2000). „The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae”. Proc. Natl. Acad. Sci. USA. 97: 5173—5178. PMID 10779558.

[1]

[2]

[3]

TRNK (adenin58-N1)-metiltransferaza

Reference

Literatura

Spoljašnje veze