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TRNK (adenin-N1-)-metiltransferaza
TRNK (adenin-N1-)-metiltransferaza
Identifikatori
EC broj	2.1.1.36
CAS broj	37257-03-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

TRNK (adenin-N1-)-metiltransferaza (EC 2.1.1.36, transfer ribonukleat adeninska 1-metiltransferaza, transfer RNK (adenin-1) metiltransferaza, 1-metiladenin transfer RNK metiltransferaza, adenin-1-metilaza, S-adenozil-L-metionin:tRNK (adenin-1-N-)-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (adenin-N1-)-metiltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + tRNK

\rightleftharpoons

S-adenozil-L-homocistein + tRNK N1-metiladenin

Enzimi iz različitih izvora su specifični za različite adeninske ostatke u tRNK.

Reference

^ Baguley, B.C. & Staehelin, M. (1968). „The specificity of transfer ribonucleic acid methylases from rat liver”. Biochemistry. 7: 45—50. PMID 4921283.
^ Björk, G.R. & Svensson, I. (1969). „Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae”. Eur. J. Biochem. 9: 207—215. PMID 4896260.
^ Dubois, E.E., Dirheimer, G. and Weil, J.H. (1974). „Methylation of yeast tRNA Asp by enzymes from cytoplasm, chloroplasts and mitochondria of Phaseolus vulgaris”. Biochim. Biophys. Acta. 374: 332—341. PMID 4611497.
^ Glick, J.M. & Leboy, P.S. (1977). „Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver”. J. Biol. Chem. 252: 4790—4795. PMID 17605.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

TRNA+(adenine-N1-)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Baguley, B.C. & Staehelin, M. (1968). „The specificity of transfer ribonucleic acid methylases from rat liver”. Biochemistry. 7: 45—50. PMID 4921283.

[2] Björk, G.R. & Svensson, I. (1969). „Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae”. Eur. J. Biochem. 9: 207—215. PMID 4896260.

[3] Dubois, E.E., Dirheimer, G. and Weil, J.H. (1974). „Methylation of yeast tRNA Asp by enzymes from cytoplasm, chloroplasts and mitochondria of Phaseolus vulgaris”. Biochim. Biophys. Acta. 374: 332—341. PMID 4611497.

[4] Glick, J.M. & Leboy, P.S. (1977). „Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver”. J. Biol. Chem. 252: 4790—4795. PMID 17605.

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